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CTBP2 produces alternative transcripts encoding two distinct proteins.
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Results indicated that CTBP2 was direct target of miR (zeige MLXIP ELISA Kits)-338-5p in glioma cells. CTBP2 silencing can rescued the phenotype changes induced by miR (zeige MLXIP ELISA Kits)-338-5p inhibitor on cell proliferation and invasion in glioma.
this study shows that CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis
these findings provide insight into the role CtBP2 plays in promoting proliferation and migration in breast cancer by the inhibition of p16INK4A.
Pinin and CtBP1 (zeige CTBP1 ELISA Kits) and CtBP2 are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
CtBP2 ameliorated palmitic acid-induced insulin (zeige INS ELISA Kits) resistance via ROS (zeige ROS1 ELISA Kits)-dependent JNK (zeige MAPK8 ELISA Kits) pathway.
CtBP2 is a druggable transforming oncoprotein critical for the evolution of neoplasia driven by Apc (zeige APC ELISA Kits) mutation.
CtBP2 may be a potential target to suppress tumorigenesis in neuroblastoma
This Gene-based tests suggest evidence of association with related genes, ZEB2 (zeige ZEB2 ELISA Kits), RND3, MCTP1, CTBP2, and beta EEG
Our results indicated that CCNH (zeige CCNH ELISA Kits)/CDK7 (zeige CDK7 ELISA Kits)-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
Releasing the key adipogenic regulator C/EBPalpha (zeige CEBPA ELISA Kits) from CtBP2 binding.
These findings suggest a suppressive function for Ctbp2 in reducing the protein level of beta-catenin (zeige CTNNB1 ELISA Kits), along with priming its position on core pluripotency genes to hinder beta-catenin (zeige CTNNB1 ELISA Kits) deposition, which is central to commitment to the appropriate lineage.
studies revealed a new epigenetic pathway in the control of IL-2 (zeige IL2 ELISA Kits) production in systemic lupus erythematosus whereby low levels of miR (zeige MLXIP ELISA Kits)-200a-3p accumulate the binding of the ZEB1 (zeige ZEB1 ELISA Kits)-CtBP2 complex to the IL-2 (zeige IL2 ELISA Kits) promoter and suppress IL-2 (zeige IL2 ELISA Kits) production
Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2 (zeige CA2 ELISA Kits)+) channels
Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment.
Phosphorylation of KLF3 and CtBP2 by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3.
propose that Zscan4 may regulate gene transcription in mouse ES cells through interaction with LSD1 (zeige KDM1A ELISA Kits) and CtBP2
RIBEYE(B) interacts with ArfGAP3 (zeige ARFGAP3 ELISA Kits) in vivo and in vitro.
CTBP2 is indispensable to create a chromatin environment conducive for RAR (zeige RARA ELISA Kits)/RXR-mediated transcription by recruiting the histone acetyltransferase p300 (zeige EP300 ELISA Kits).
Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.
Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors
In photoreceptor cells, RIBEYE and RIM2 are expressed along the synaptic ribbon.
Tcf-3 (zeige TCF3 ELISA Kits) functions as a transcriptional regulator in the canonical Wnt (zeige WNT2 ELISA Kits) signaling cascade and can repress or activate downstream target genes. The tcf-3 (zeige TCF3 ELISA Kits) promoter was analyzed during early development of Xenopus.
Together, these results demonstrate that signaling through Tcf (zeige HNF4A ELISA Kits) and Vent binding sites regulates transcription of geminin (zeige GMNN ELISA Kits) in prospective neurectoderm during gastrulation
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3\; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
C-terminal binding protein 2
, C-terminal-binding protein 2-like
, C-terminal-binding protein 2
, gene trap ROSA b-geo 6
, ribeye a
, C-terminal-binding protein B
, TCF-3 corepressor CtBP
, Tcf-3 co-repressor CtBP