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CTBP2 produces alternative transcripts encoding two distinct proteins.
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Rat (Rattus) Polyclonal CTBP2 Primary Antibody für IHC - ABIN1742397
Regus-Leidig, tom Dieck, Brandstätter: Absence of functional active zone protein Bassoon affects assembly and transport of ribbon precursors during early steps of photoreceptor synaptogenesis. in European journal of cell biology 2010
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Human Polyclonal CTBP2 Primary Antibody für ICC, IHC - ABIN1742398
Dominik Fischer, Zobor, Keliris, Shao, Seeliger, Haverkamp, Jägle, Logothetis, Smirnakis: Detailed functional and structural characterization of a macular lesion in a rhesus macaque. in Documenta ophthalmologica. Advances in ophthalmology 2016
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Human Polyclonal CTBP2 Primary Antibody für IHC, WB - ABIN1742396
Zabouri, Haverkamp: Calcium channel-dependent molecular maturation of photoreceptor synapses. in PLoS ONE 2013
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Human Polyclonal CTBP2 Primary Antibody für ELISA, WB - ABIN560519
Debiais-Delpech, Godet, Pedretti, Bernard, Irani, Cathelineau, Cussenot, Fromont: Expression patterns of candidate susceptibility genes HNF1? and CtBP2 in prostate cancer: association with tumor progression. in Urologic oncology 2014
Results indicated that CTBP2 was direct target of miR (zeige MLXIP Antikörper)-338-5p in glioma cells. CTBP2 silencing can rescued the phenotype changes induced by miR (zeige MLXIP Antikörper)-338-5p inhibitor on cell proliferation and invasion in glioma.
this study shows that CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis
these findings provide insight into the role CtBP2 plays in promoting proliferation and migration in breast cancer by the inhibition of p16INK4A.
Pinin (zeige PNN Antikörper) and CtBP1 (zeige CTBP1 Antikörper) and CtBP2 are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
CtBP2 ameliorated palmitic acid-induced insulin (zeige INS Antikörper) resistance via ROS (zeige ROS1 Antikörper)-dependent JNK (zeige MAPK8 Antikörper) pathway.
CtBP2 is a druggable transforming oncoprotein critical for the evolution of neoplasia driven by Apc (zeige APC Antikörper) mutation.
CtBP2 may be a potential target to suppress tumorigenesis in neuroblastoma (zeige ARHGEF16 Antikörper)
This Gene-based tests suggest evidence of association with related genes, ZEB2 (zeige ZEB2 Antikörper), RND3 (zeige RND3 Antikörper), MCTP1, CTBP2, and beta EEG
Our results indicated that CCNH (zeige CCNH Antikörper)/CDK7 (zeige CDK7 Antikörper)-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
Releasing the key adipogenic regulator C/EBPalpha (zeige CEBPA Antikörper) from CtBP2 binding.
These findings suggest a suppressive function for Ctbp2 in reducing the protein level of beta-catenin (zeige CTNNB1 Antikörper), along with priming its position on core pluripotency genes to hinder beta-catenin (zeige CTNNB1 Antikörper) deposition, which is central to commitment to the appropriate lineage.
studies revealed a new epigenetic pathway in the control of IL-2 (zeige IL2 Antikörper) production in systemic lupus erythematosus whereby low levels of miR (zeige MLXIP Antikörper)-200a-3p accumulate the binding of the ZEB1 (zeige ZEB1 Antikörper)-CtBP2 complex to the IL-2 (zeige IL2 Antikörper) promoter and suppress IL-2 (zeige IL2 Antikörper) production
Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2 (zeige CA2 Antikörper)+) channels
Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs (zeige NR2E3 Antikörper) that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment.
Phosphorylation of KLF3 (zeige KLF3 Antikörper) and CtBP2 by HIPK2 (zeige HIPK2 Antikörper) strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (zeige KLF3 Antikörper).
propose that Zscan4 (zeige ZSCAN4 Antikörper) may regulate gene transcription in mouse ES cells through interaction with LSD1 (zeige KDM1A Antikörper) and CtBP2
RIBEYE(B) interacts with ArfGAP3 (zeige ARFGAP3 Antikörper) in vivo and in vitro.
CTBP2 is indispensable to create a chromatin environment conducive for RAR (zeige RARA Antikörper)/RXR-mediated transcription by recruiting the histone acetyltransferase p300 (zeige EP300 Antikörper).
Study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions.
Ctbp2 has a role in maintaining a balance in decisions to self-renewal and differentiate in embryonic stem cells and mesodermal progenitors
In photoreceptor cells, RIBEYE and RIM2 (zeige RIMS2 Antikörper) are expressed along the synaptic ribbon.
Tcf-3 (zeige TCF3 Antikörper) functions as a transcriptional regulator in the canonical Wnt (zeige WNT2 Antikörper) signaling cascade and can repress or activate downstream target genes. The tcf-3 (zeige TCF3 Antikörper) promoter was analyzed during early development of Xenopus.
Together, these results demonstrate that signaling through Tcf (zeige HNF4A Antikörper) and Vent binding sites regulates transcription of geminin (zeige GMNN Antikörper) in prospective neurectoderm during gastrulation
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3\; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
C-terminal binding protein 2
, C-terminal-binding protein 2-like
, C-terminal-binding protein 2
, gene trap ROSA b-geo 6
, ribeye a
, C-terminal-binding protein B
, TCF-3 corepressor CtBP
, Tcf-3 co-repressor CtBP