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CLEC12A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.
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CLL-1 (zeige COLEC10 ELISA Kits) is a novel prognostic predictor that could be exploited to supplement the current acute myeloid leukemia (zeige BCL11A ELISA Kits) prognostic risk stratification system.
BMI-1 (zeige BMI1 ELISA Kits), TIM-3 (zeige HAVCR2 ELISA Kits) and CLL-1 (zeige COLEC10 ELISA Kits) have roles in acute myeloid leukemia (zeige BCL11A ELISA Kits) prognosis and therapy
The CLEC12A is an effective new candidate with great potential for in vivo Ag delivery into mDCs and pDCs, thereby using the specialized functions and cross-talk capacity of these DC subsets to boost tumor-reactive T cell immunity in cancer patients.
Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS.
We propose the hypothesis that decreased expression of CLEC12A is a common denominator in the hyperinflammatory responses observed in Behcet's syndrome and gout.
Antibacterial autophagy is impaired in CLEC12A-deficient cells, and this effect is exacerbated in the presence of the ATG16L1( *)300A risk allele.
Upon CLL1 (zeige COLEC10 ELISA Kits)-selective binding of this fusion protein, granulocytes acquire additional TRAIL-mediated cytotoxic activity that, importantly, potentiates antibody-mediated cytotoxicity of clinically used therapeutic antibodies
We conclude the hMICL/CD123 (zeige IL3RA ELISA Kits)-based MFC assay is a promising MRD tool in AML (zeige RUNX1 ELISA Kits).
There is a potential genetic association of CLEC12A with rheumatoid arthritis (RA). Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA.
For production of cytotoxic T cells, transgenic DEC-205 (zeige LY75 ELISA Kits) and Clec9A (zeige CLEC9A ELISA Kits), but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants.
Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting
Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.
Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1]
CLL-1 expression is also present on the CD34 (zeige CD34 ELISA Kits)(+)CD38(-) stem- cell compartment in acute myeloid leukemia (zeige BCL11A ELISA Kits)
Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
C-type lectin domain family 12, member A
, C-type lectin domain family 12 member A
, C-type lectin protein CLL-1
, C-type lectin superfamily
, C-type lectin-like molecule-1
, dendritic cell-associated lectin 2
, myeloid inhibitory C-type lectin-like receptor
, C-type lectin-like molecule 1