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CLEC10A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Zusätzlich bieten wir Ihnen CLEC10A Antikörper (136) und CLEC10A Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 22 products:
this paper shows that key gene of intermediate proinflammatory monocytes, such as CLEC10A, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis
BRAF (zeige BRAF Proteine)(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans in colorectal neoplasms.
These results indicate a role of MGL as an immunomodulator within the tumour microenvironment interfering with Treg functions, suggesting its possible use in the design of anticancer vaccines.
expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL.
MGL triggering synergized with TLR2-induced pathways, leading to elevated IL-10 (zeige IL10 Proteine) mRNA levels & enhanced TNF-alpha (zeige TNF Proteine) mRNA stability. It promoted phosphorylation of the ERK (zeige EPHB2 Proteine) & CREB (zeige CREB1 Proteine), fine-tuning the DC maturation phenotype.
Described is the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin (zeige MBL2 Proteine) family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.
MGL engagement improved DC performance as antigen-presenting cells, promoting the upregulation of maturation markers, a decrease in phagocytosis, an enhancement of motility, and most importantly an increase in antigen-specific CD8 (zeige CD8A Proteine)(+) T-cell activation.
Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia
Mgl1 (zeige LLGL1 Proteine)-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility.
MGL1 (zeige LLGL1 Proteine) is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.
The MGL1 (zeige LLGL1 Proteine) functions as an attachment and entry receptor for influenza A virus.
Syk (zeige SYK Proteine) was involved in the CLR (zeige CALCR Proteine)-mediated activation of mast cells by BP
Hoxc8 (zeige HOXC8 Proteine) downregulates Mgl1 (zeige LLGL1 Proteine) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
The authors conclude that lectin-mediated interactions of influenza virus with the MMR (zeige MRC1 Proteine) or the MGL are required for the endocytic uptake of the virus into macrophages.
mMGL1 preferentially binds Lewis X (zeige FUT4 Proteine)-conjugated soluble polyacrylamides
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.
sialoadhesin (zeige SIGLEC1 Proteine) acts as an endogenous counter-receptor for MGL1 (zeige LLGL1 Proteine)
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.
C-type lectin domain family 10, member A
, C-type lectin, superfamily member 14
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived)
, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived)
, C-type lectin domain family 10 member A
, macrophage lectin 2 (calcium dependent)
, macrophage asialoglycoprotein-binding protein 1
, macrophage galactose N-acetyl-galactosamine specific lectin 1
, Gal/GalNAc-specific lectin
, macrophage galactose/N-acetylgalactosamine-specific lectin
, monoglyceride lipase