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CMIP encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway.
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CMIP knockdown was observed to result in the downregulation of MDM2 (zeige MDM2 Proteine) and mitogen activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) expression at the mRNA level and CMIP was a direct target of miR1013p.
CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.
These findings suggest that CMIP haploinsufficiency is the likely cause of syndromic Autism spectrum disorder in our patients.
Wilm's tumor protein (WT1) bound to 2 WT (zeige WT1 Proteine)1 response elements, located at positions -290/-274 and -57/-41 relative to transcription start site.
Results suggest that c-mip and RelA (zeige NFkBP65 Proteine) define two distinct types of renal damage associated with VEGF (zeige VEGFA Proteine)-targeted therapies.
c-mip has an active role in the podocyte disorders of membranous nephropathy.
These results suggest that alterations in NF-kappaB (zeige NFKB1 Proteine) activity might result from the up-regulation of c-mip and are likely to contribute to podocyte disorders in cases of idiopathic nephrotic syndrome.
we provide novel evidence that the language-disorder candidate gene CMIP is implicated in reading processes.
Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1 (zeige DCLK1 Proteine), PTPRD (zeige PTPRD Proteine), GRM8 (zeige GRM8 Proteine), CMIP.
results identify c-mip as a key component in the molecular pathogenesis of acquired podocyte diseases
Unlike the human CMIP gene, only one Wt1 (zeige WT1 Proteine) response element was identified in the mouse Cmip proximal promoter located at position -217/-206.
the c-mip protein is involve in regulating nephrin (zeige NPHS1 Proteine) phosphorylation through Csk (zeige CSK Proteine)-Cbp/PAG-Fyn (zeige FYN Proteine) signaling pathway.
Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase (zeige COMT Proteine)).
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.