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BUB1B encodes a kinase involved in spindle checkpoint function. Zusätzlich bieten wir Ihnen BUB1B Antikörper (178) und BUB1B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (zeige CDC20 Proteine)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (zeige MYO5A Proteine) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (zeige PPP2R4 Proteine) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (zeige PPP2R4 Proteine) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (zeige MAD2L1 Proteine) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (zeige BUB3 Proteine) complex depends on the specific recognition between BubR1 and Bub3 (zeige BUB3 Proteine), for which the BubR1 Gle2 (zeige RAE1 Proteine) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (zeige BUB3 Proteine) by BUB1 (zeige BUB1 Proteine) is dispensable for SAC (zeige ADCY10 Proteine) activation
The combination of budding uninhibited by benzimidazole-related 1 (BUBR1) insufficiency and administration of KBrO3 worsens the proliferative capacity compared with the impaired proliferation induced by BUBR1 insufficiency alone.
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (zeige EZH2 Proteine) directly interacted with and stabilized BubR1, an effect driving EZH2 (zeige EZH2 Proteine) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (zeige BUB3 Proteine), and Ercc1 (zeige ERCC1 Proteine)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (zeige ERCC1 Proteine)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (zeige SGOL1 Proteine) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (zeige SIRT2 Proteine) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (zeige CREBBP Proteine).
Together, our findings demonstrate that Bub1 (zeige BUB1 Proteine) acts at multiple points to assure the correct kinetochore formation.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
MAD3/BUB1-related protein kinase
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint kinase MAD3L
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog, beta
, BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like