Bromodomain, Testis-Specific Proteine (BRDT)

BRDT is similar to the RING3 protein family. Zusätzlich bieten wir Ihnen BRDT Antikörper (45) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
BRDT 676 Q58F21
BRDT 114642 Q91Y44
Ratte BRDT BRDT 305123  
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Top BRDT Proteine auf

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant BRDT (21-137) activity using AlphaScreen. BRDT (21-137) titration and inhibition were assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. An IC50 dose response assessment of reference compounds JQ1, I-BET151, Bromosporine and PFI-1 is also shown. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRDT (21-137) protein gel. BRDT (21-137) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage

BRDT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)

Weitere Proteine zu Bromodomain, Testis-Specific (BRDT) Interaktionspartnern

Human Bromodomain, Testis-Specific (BRDT) Interaktionspartner

  1. FBP1 modulates the sensitivity of pancreatic cancer cells to BET inhibitors by decreasing the expression of c-Myc. These findings highlight FBP1 could be used as a therapeutic niche for patient-tailored therapies

  2. The bromodomain and extraterminal domain (BET) family consists of BRDT, BRD2, BRD3, and BRD4, each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.

  3. The affected patient carries a homozygous bromodomain, testis-specific protein (BRDT) mutation, while the patient's father, mother and elder brother all carry heterozygous BRDT mutations.

  4. considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT genes in Chinese patients with non-obstructive azoospermia

  5. assessment of rs3088232 frequency in large group of non-obstructive azoospermia men and fertile controls demonstrated no significant difference between them; conclude that testicular impairments observed were not a consequence of BRDT gene mutation

  6. In human, BRDT is the only BET gene expressed exclusively in testicular germ cells.

  7. Suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients.

  8. BRDT-NY gene is an alternatively spliced variant that may have an important role in the process of spermatogenesis and may be correlated with male infertility

Mouse (Murine) Bromodomain, Testis-Specific (BRDT) Interaktionspartner

  1. BRDT controls the global chromatin organization and histone modifications of the chromatin attached to the synaptonemal complex. BRDT role in the silencing of sex chromosomes and crossover formation in male meiosis.

  2. Our results suggest that in addition to its critical role in the spermatogenesis process, the BRDT protein is also responsible for scheduling male puberty by regulation of the pituitary-gonad axis.

  3. It was shown that Brdt is a unique and essential regulator of male germ cell differentiation, first by driving a specific spermatogenic gene expression program and then by controling the tight packaging of the male genome.

  4. The N terminus of Brdt is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.

  5. the first bromodomain of Brdt is critical in the formation and/or maintenance of an intact chromocenter and implicate this structure in proper remodeling of the chromatin architecture of the sperm head.

  6. phylogenetic analyses show that the BRDT germ cell-specific orthology group clearly evolves faster than its ubiquitously expressed paralogs BRD2, BRD3, and BRD4

  7. Homozygous Brdt(Delta)(BD1/)(Delta)(BD1) mice were viable but males were sterile, producing fewer and morphologically abnormal sperm.

  8. a single bromodomain (BD1) of Brdt is responsible for selectively recognizing histone H4 tails bearing two or more acetylation marks

BRDT Protein Überblick

Protein Überblick

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit BRDT

  • bromodomain testis associated (BRDT)
  • bromodomain, testis-specific (Brdt)
  • bromodomain testis associated (Brdt)
  • bromodomain, testis-specific L homeolog (brdt.L)
  • bromodomain, testis-specific (brdt)
  • 7420412D09Rik Protein
  • Brd6 Protein
  • BRDT Protein
  • CT9 Protein
  • fi25h02 Protein
  • Fsrg3 Protein
  • MGC151933 Protein
  • si:dkeyp-85h7.3 Protein
  • wu:fi25h02 Protein

Bezeichner auf Proteinebene für BRDT

RING3-like protein , bromodomain testis-specific protein , cancer/testis antigen 9 , bromodomain-containing female sterile homeotic-like protein , female sterile homeotic-related gene 3 , bromodomain, testis-specific , testis-specific bromodomain protein , LOW QUALITY PROTEIN: bromodomain testis-specific protein

676 Homo sapiens
114642 Mus musculus
305123 Rattus norvegicus
398944 Xenopus laevis
424506 Gallus gallus
469382 Pan troglodytes
479954 Canis lupus familiaris
523971 Bos taurus
100144959 Xenopus (Silurana) tropicalis
100026533 Monodelphis domestica
100586227 Nomascus leucogenys
100719653 Cavia porcellus
333996 Danio rerio
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