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BRDT is similar to the RING3 protein family.
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The bromodomain and extraterminal domain (BET) family consists of BRDT, BRD2 (zeige BRD2 Proteine), BRD3 (zeige BRD3 Proteine), and BRD4 (zeige BRD4 Proteine), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The affected patient carries a homozygous bromodomain, testis-specific protein (zeige DMRT3 Proteine) (BRDT) mutation, while the patient's father, mother and elder brother all carry heterozygous BRDT mutations.
considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 (zeige RNF8 Proteine) and BRDT genes in Chinese patients with non-obstructive azoospermia
assessment of rs3088232 frequency in large group of non-obstructive azoospermia men and fertile controls demonstrated no significant difference between them; conclude that testicular impairments observed were not a consequence of BRDT gene mutation
In human, BRDT is the only BET gene expressed exclusively in testicular germ cells.
Suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients.
BRDT-NY gene is an alternatively spliced variant that may have an important role in the process of spermatogenesis and may be correlated with male infertility
Our results suggest that in addition to its critical role in the spermatogenesis process, the BRDT protein is also responsible for scheduling male puberty by regulation of the pituitary-gonad axis.
It was shown that Brdt is a unique and essential regulator of male germ cell differentiation, first by driving a specific spermatogenic gene expression program and then by controling the tight packaging of the male genome.
The N terminus of Brdt is involved in the recognition of Smarce1 (zeige SMARCE1 Proteine) as well as in the reorganization of hyperacetylated round spermatid chromatin.
the first bromodomain of Brdt is critical in the formation and/or maintenance of an intact chromocenter and implicate this structure in proper remodeling of the chromatin architecture of the sperm head.
phylogenetic analyses show that the BRDT germ cell-specific orthology group clearly evolves faster than its ubiquitously expressed paralogs BRD2 (zeige BRD2 Proteine), BRD3 (zeige BRD3 Proteine), and BRD4 (zeige BRD4 Proteine)
Homozygous Brdt(Delta)(BD1 (zeige DEFB1 Proteine)/)(Delta)(BD1 (zeige DEFB1 Proteine)) mice were viable but males were sterile, producing fewer and morphologically abnormal sperm.
a single bromodomain (BD1) of Brdt is responsible for selectively recognizing histone H4 tails bearing two or more acetylation marks
BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene.
, bromodomain testis-specific protein
, cancer/testis antigen 9
, bromodomain-containing female sterile homeotic-like protein
, female sterile homeotic-related gene 3
, bromodomain, testis-specific
, testis-specific bromodomain protein
, LOW QUALITY PROTEIN: bromodomain testis-specific protein