anti-Biotin-Protein Ligase (HLCS) Antikörper

HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. Zusätzlich bieten wir Ihnen Biotin-Protein Ligase Proteine (5) und Biotin-Protein Ligase Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HLCS 110948 Q920N2
HLCS 3141 P50747
HLCS 288240  
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Top anti-Biotin-Protein Ligase Antikörper auf antikoerper-online.de

Showing 10 out of 30 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert FACS, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$522.50
Details
Human Maus Unkonjugiert FACS, IHC, WB HEK293T cells transfected with either RC209197 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-HLCS antibody (ABIN2455633), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HLCS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-HLCS. 0.1 mL Anmelden zum Anzeigen 2 bis 3 Tage
$482.90
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: HLCS Antibody [NBP1-81759] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4 Immunocytochemistry/Immunofluorescence: HLCS Antibody [NBP1-81759] - Staining of human cell line U-2 OS shows positivity in cytoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert IP, WB Immunoprecipitation of HLCS transfected lysate using anti-HLCS MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with HLCS MaxPab rabbit polyclonal antibody (D01) . Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane 1: HLCS transfected lysate(80.80 KDa).Lane 2: Non-transfected lysate. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$337.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: HLCS Antibody [NBP2-16856] - Sample (30 ug of whole cell lysate) A: K562 7. 5% SDS PAGE gel, diluted at 1:2000. Immunohistochemistry-Paraffin: HLCS Antibody [NBP2-16856] - Immunohistochemical analysis of paraffin-embedded Hepatoma, using antibody at 1:500 dilution. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$516.98
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$227.50
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane 1: HLCS transfected lysate(80.80 KDa).Lane 2: Non-transfected lysate. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$337.50
Details
Human Maus Unkonjugiert WB Western Blot analysis of HLCS expression in transfected 293T cell line by HLCS MaxPab polyclonal antibody.Lane1:HLCS transfected lysate(79.86 KDa).Lane2:Non-transfected lysate. 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$348.04
Details
Human Maus Biotin WB   50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$837.83
Details
Human Kaninchen Biotin WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$903.83
Details

Am meisten referenzierte anti-Biotin-Protein Ligase Antikörper

  1. Human Polyclonal HLCS Primary Antibody für ICC, IF - ABIN4319286 : Niers, Chen, Weissleder, Tannous: Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. in Analytical chemistry 2011 (PubMed)

Weitere Antikörper gegen Biotin-Protein Ligase Interaktionspartner

Human Biotin-Protein Ligase (HLCS) Interaktionspartner

  1. The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed.

  2. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7

  3. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1) contribute toward transcriptional repression of repeats, presumably increasing genome stability.

  4. study characterizes three functional promoters in the human HLCS gene

  5. HLCS interacts physically with the DNA methyltransferase DNMT1 and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin.

  6. This study showed that modification of HSP72 and demonstrated that binding of biotin to extracellular HSP72 prepares cells for a strong immune response.

  7. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype

  8. HLCS methionine-58 is a functional translation start site in human cells.

  9. Holocarboxylase synthetase interacts directly with histone H3, causing biotinylation of lysine K9 and K18.

  10. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population

  11. The results of this study suggest that miR-539 is among the factors sensing biotin and regulating holocarboxylase synthetase expression.

  12. Data suggest that the N-terminal domain of hHCS recognizes the charged region of biotin acceptor protein, distinctly from the recognition by the catalytic domain.

  13. the localisation of HCS and its isoforms

  14. The mutations R508W and V363D of holocarboxylase synthetase might be hot-spots in Chinese children with holocarboxylase synthetas deficiency.

  15. The study shows that not all the proteins and polypeptides that interact with holocarboxylase synthetase are targets for biotinylation, but that carboxylase- and histone-like structures are preferred HCS targets.

  16. These results provide insights into substrate recognition by hHCS, which can be distinguished from BirA in this respect.

  17. 12 patients with multiple carboxylase deficiency, six mutations were found in the BT gene and 4 in the HLCS gene, including 5 novel mutations.

  18. 6 HLCS mutations were identified, including 2 new (N511K and G582R) and 4 known missense mutations (L216R, R508W, V550M, and G581S). 5 are in the biotin-binding domain. Tthe L216R change is in the N-terminal region outside the biotin-binding domain.

  19. Detection of mutations by tandem mass spectrometry in Carnitine transporter deficiency.

  20. findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells.

Biotin-Protein Ligase (HLCS) Antigen-Profil

Protein Überblick

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Genbezeichner und Symbole assoziert mit HLCS

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs) Antikörper
  • holocarboxylase synthetase (HLCS) Antikörper
  • holocarboxylase synthetase (Hlcs) Antikörper
  • 410I21.SP6 Antikörper
  • D16Jhu34 Antikörper
  • HCS Antikörper
  • RGD1565360 Antikörper

Bezeichner auf Proteinebene für HLCS

biotin apo-protein ligase , biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase , biotin--protein ligase , biotin--[acetyl-CoA-carboxylase] ligase , biotin--[methylcrotonoyl-CoA-carboxylase] ligase , biotin--[methylmalonyl-CoA-carboxytransferase] ligase , holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) , holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

GENE ID SPEZIES
110948 Mus musculus
3141 Homo sapiens
288240 Rattus norvegicus
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