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Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity)..
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Human Polyclonal BOD1 Primary Antibody für ELISA - ABIN4256618
Porter, McClelland, Khoudoli, Hunter, Andersen, McAinsh, Blow, Swedlow: Bod1, a novel kinetochore protein required for chromosome biorientation. in The Journal of cell biology 2007
Kinetochore targeting of Bod1 depends on Ndc80 (zeige NDC80 Antikörper) and not PP2A (zeige PPP2R4 Antikörper)-B56. Bod1 depletion functionally affects Ndc80 (zeige NDC80 Antikörper) phosphorylation at S55.
these results suggest that radiation alters miR (zeige MLXIP Antikörper)-142-3p and Bod1 expression in carcinoma cells, and thus contributes to early stages of radiation-induced genomic instability
we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase.
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).
biorientation defective 1
, biorientation of chromosomes in cell division protein 1
, family with sequence similarity 44, member B
, biorientation defective protein 1
, bone length and organs 1