anti-Bassoon (BSN) Antikörper

Mouse (Murine) Bassoon (BSN) Interaktionspartner

1. The expression of Bassoon in excitatory forebrain neurons is required for the normal maturation of the dentate gyrus and important for spatial and contextual memory.

2. Piccolo puncta sandwiched Bassoon puncta and aligned in a Piccolo-Bassoon-Piccolo structure in adult neuromuscular junctions (NMJs). P/Q-type voltage-gated calcium channel (VGCC) puncta colocalized with Bassoon puncta. The P/Q-type VGCC and Bassoon protein levels decreased significantly in NMJs from aged mouse. In contrast, the Piccolo levels in NMJs from aged mice were comparable to levels in adult mice.

3. These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites.

4. Authors conclude that bassoon promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse.

5. phosphorylation-induced 14-3-3 binding to Bassoon modulates its anchoring to the presynaptic cytomatrix

6. proper assembly of ribbon synapses depend on Bassoon

7. a novel role for Bassoon and Piccolo as critical regulators of presynaptic ubiquitination and proteostasis.

8. This studyy demonistrated that reduced bassoon expression or complete lack of full-length bassoon impaired sound encoding to a similar extent, which is consistent with the comparable reduction of the readily releasable vesicle pool

9. hippocampal overgrowth in Bassoon-mutant mice arises from a dysregulation of neurogenesis and apoptosis that might be associated with unbalanced BDNF levels.

10. Results support the notion that Bassoon is important for organizing the presynaptic active zone during the postnatal maturation of glutamatergic synapses.

11. Our findings reveal a novel function of Bassoon in the early formation and delivery of precursor spheres to nascent ribbon synaptic sites

12. piccolo and bassoon play a redundant role in synaptic vesicle clustering in nerve terminals without directly participating in neurotransmitter release.

13. Deficiency of Bassoon, a major component of the photoreceptor ribbon, results in impaired photoreceptor synaptic transmission, abnormal dendritic branching of neurons postsynaptic to photoreceptors, and the formation of ectopic synapses.

14. Loss of Bassoon in Bsn mutant mice causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses.

15. the absence of the functional presynaptic protein Bassoon causes disturbance in the formation of normal basal cortical activation patterns and thereby in the functional cortical architecture

16. altered neuronal activation pattern in the cortex is reflected not only in defined cytoarchitectural anomalies but also in metabolic disturbances in the glutamine-glutamate and N-acetyl aspartate metabolism in Bsn mutants

17. true cone-selective type 1 and 2 OFF cone bipolar cells did not show sprouting in the Bassoon mouse mutant

Human Bassoon (BSN) Interaktionspartner

1. Three missense mutations in BSN that are very rarely listed in databases of healthy subjects were found in four sporadic progressive supranuclear palsy cases. Western blot analysis of tau following the overexpression of wild-type or mutated BSN revealed the possibility that wild-type BSN reduced tau accumulation, while mutated BSN lost this function.

2. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.

3. Short-term synaptic depression is enhanced in Bassoon knockout mice, but synaptic transmission is unaffected.

4. Bassoon protein and the synaptic ribbon create a large number of release sites by organizing calcium channels and synaptic vesicles.

5. Loss of Bassoon in Bsn mutant mice causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses.

6. The effect of BSN-MST1 locus on Crohn's disease predisposition was replicated, but no influence on ulcerative colitis or multiple sclerosis predisposition could be detected

7. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

8. This paper describes the structure of the mouse and rat Bsn genes, and characterizes the subcellular distribution of the Bassoon protein.