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The protein encoded by BNC1 is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles.
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Study shows that BNC1 expression was down-regulated in hepatocellular tumors and cell lines through its promotor hypermethylation.
Study demonstrates that Bnc1 regulates epithelial plasticity of mammary epithelial cells and influences outcome of TGF-beta1 (zeige TGFB1 ELISA Kits) signaling.
p63 (zeige RPE65 ELISA Kits) induces the expression of the basal epithelial transcription factor, Basonuclin 1.
Data show that basonuclin (Bn)2 but not bn1 (zeige CCR6 ELISA Kits) colocalizes with SC35 (zeige SRSF2 ELISA Kits) in nuclear speckles, and may have a function in nuclear processing of mRNA.
BNC1 cannot substitute for BNC2.
HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis.
BNC1 is required for the maintenance of spermatogenesis.
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.
zinc finger protein basonuclin-1
, basonuclin 1
, zinc finger protein basonuclin-1-like
, zinc finger protein basonuclin