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Transcriptional regulator that acts as repressor or activator.
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The study demonstrates that Bach2 is a direct repressor of the interleukin-2 (zeige IL2 Proteine) gene in CD4 (zeige CD4 Proteine) T cells during the immediate early (zeige JUN Proteine) phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state
Results suggest that the mTOR (zeige FRAP1 Proteine)-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement.
The Bach2-C/EBPbeta (zeige CEBPB Proteine) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells.
Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB (zeige NFKB1 Proteine) subunit proto-oncogene (zeige RAB1A Proteine) protein c (zeige PROC Proteine)-rel (c-Rel (zeige NFkBP65 Proteine)) .
In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.
this study shows that the transcription factor BACH2 promotes memory CD8 (zeige CD8A Proteine)+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 (zeige JUN Proteine)
this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells
Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 (zeige IL5 Proteine) in CD4 (zeige CD4 Proteine)(+) T cells.
These results suggest that Bach1 (zeige BACH1 Proteine) and Bach2 work in a complementary manner to maintain the normal function of the AMs (zeige MAT1A Proteine) and surfactant homeostasis in the lung.
The epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) pathway was also influenced by miR (zeige MLXIP Proteine)-130a-3p down-regulation. In conclusion, miR (zeige MLXIP Proteine)-130a-3p could bind to BACH2, inhibit nasopharyngeal carcinoma cell abilities, and promote cell apoptosis.
Ikaros (zeige IKZF1 Proteine) regulates expression of the BCL6 (zeige BCL6 Proteine)/BACH2 axis in acute lymphoblastic leukemia cells.
Data show that BACH2 and STAT5B (zeige STAT5B Proteine) are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.
BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.
BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (zeige HELLS Proteine) consisting of deactivated Cas9 (dCas9) nuclease (zeige DCLRE1C Proteine) and catalytic domain of the DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A (zeige DNMT3A Proteine) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (zeige HELLS Proteine) of a wider promoter region of the target loci IL6ST (zeige IL6ST Proteine) and BACH2 decreased their expression
genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.
The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.
The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).
BTB and CNC homolog 2
, Transcription regulator protein BACH2 (BTB and CNC homolog 2)
, transcription regulator protein BACH2
, BTB and CNC homology 2
, BTB and CNC homology 1, basic leucine zipper transcription factor 2
, transcription regulator protein BACH2-like