BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 Proteine (BACH2)

Transcriptional regulator that acts as repressor or activator. Zusätzlich bieten wir Ihnen BACH2 Antikörper (63) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
BACH2 12014  
Ratte BACH2 BACH2 313125  
BACH2 60468 Q9BYV9
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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BACH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaktionspartnern

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaktionspartner

  1. Bach2 interacts with Batf family transcription factors and controls Th2 cell development via binding to the regulatory regions in the Th2 cytokine, Batf and Batf3 (zeige BATF3 Proteine) gene loci.

  2. The study demonstrates that Bach2 is a direct repressor of the interleukin-2 (zeige IL2 Proteine) gene in CD4 (zeige CD4 Proteine) T cells during the immediate early (zeige JUN Proteine) phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state

  3. Results suggest that the mTOR (zeige FRAP1 Proteine)-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement.

  4. The Bach2-C/EBPbeta (zeige CEBPB Proteine) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.

  5. Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells.

  6. Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB (zeige NFKB1 Proteine) subunit proto-oncogene (zeige RAB1A Proteine) protein c (zeige PROC Proteine)-rel (c-Rel (zeige NFkBP65 Proteine)) .

  7. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  8. this study shows that the transcription factor BACH2 promotes memory CD8 (zeige CD8A Proteine)+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 (zeige JUN Proteine)

  9. this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells

  10. Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 (zeige IL5 Proteine) in CD4 (zeige CD4 Proteine)(+) T cells.

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaktionspartner

  1. The authors show that the timed repression of BACH2 through IL-2 (zeige IL2 Proteine)-mediated ERK (zeige EPHB2 Proteine)/ELK1 (zeige ELK1 Proteine) signalling pathway directs plasma cell lineage commitment.

  2. The epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) pathway was also influenced by miR (zeige MLXIP Proteine)-130a-3p down-regulation. In conclusion, miR (zeige MLXIP Proteine)-130a-3p could bind to BACH2, inhibit nasopharyngeal carcinoma cell abilities, and promote cell apoptosis.

  3. Ikaros (zeige IKZF1 Proteine) regulates expression of the BCL6 (zeige BCL6 Proteine)/BACH2 axis in acute lymphoblastic leukemia cells.

  4. Data show that BACH2 and STAT5B (zeige STAT5B Proteine) are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.

  5. BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.

  6. BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.

  7. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  8. we developed a CRISPR-Cas9-based tool for specific DNA methylation (zeige HELLS Proteine) consisting of deactivated Cas9 (dCas9) nuclease (zeige DCLRE1C Proteine) and catalytic domain of the DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A (zeige DNMT3A Proteine) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (zeige HELLS Proteine) of a wider promoter region of the target loci IL6ST (zeige IL6ST Proteine) and BACH2 decreased their expression

  9. genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.

  10. The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.

BACH2 Protein Überblick

Protein Überblick

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).

Genbezeichner und Symbole assoziert mit BACH2

  • BTB and CNC homology, basic leucine zipper transcription factor 2 (Bach2)
  • BTB domain and CNC homolog 2 (Bach2)
  • BTB domain and CNC homolog 2 (BACH2)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2b (bach2b)
  • BTB domain and CNC homolog 2 (bach2)
  • bach2 Protein
  • BTBD25 Protein
  • E030004N02Rik Protein
  • si:dkeyp-4f12.1 Protein
  • si:dkeyp-4f12.2 Protein

Bezeichner auf Proteinebene für BACH2

BTB and CNC homolog 2 , Transcription regulator protein BACH2 (BTB and CNC homolog 2) , transcription regulator protein BACH2 , BTB and CNC homology 2 , BTB and CNC homology 1, basic leucine zipper transcription factor 2 , transcription regulator protein BACH2-like

GENE ID SPEZIES
12014 Mus musculus
313125 Rattus norvegicus
60468 Homo sapiens
421809 Gallus gallus
481923 Canis lupus familiaris
538296 Bos taurus
555350 Danio rerio
702740 Macaca mulatta
100065814 Equus caballus
100218595 Taeniopygia guttata
100351257 Oryctolagus cuniculus
100402816 Callithrix jacchus
100447938 Pongo abelii
100467178 Ailuropoda melanoleuca
100485849 Xenopus (Silurana) tropicalis
100025933 Monodelphis domestica
100554926 Anolis carolinensis
100595920 Nomascus leucogenys
100717541 Cavia porcellus
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