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BCL2A1 encodes a member of the BCL-2 protein family.
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The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2 (zeige BCL2 ELISA Kits), Mcl1 (zeige MCL1 ELISA Kits), and BCL2A1, rather than by a single anti-apoptotic protein.
This dynamic change in B cell survival mechanisms is unique to Epstein-Barr virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.
Loss of A1 alone does not impair T cell-driven immune responses. It therefore appears likely that A1 has critical overlapping functions with other pro-survival BCL-2 (zeige BCL2 ELISA Kits) proteins in T cell immune responses.
Overexpression of BCL2A1 in T lymphocytes causes selective impairment of TH17 differentiation and protection against autoimmune arthritis.
Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation.
Findings identify BCL2A/A1 as a MYC (zeige MYC ELISA Kits) target that can be induced prematurely during B cell development to aid expansion of otherwise cell-death-prone MYC (zeige MYC ELISA Kits) transgenic pre-B cells
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR (zeige BCR ELISA Kits)-dependent B-cell survival.
Knockdown of the antiapoptotic Bcl-2 (zeige BCL2 ELISA Kits) family member A1/Bfl-1 protects mice from anaphylaxis.
Bcl2a1 should be considered as a proto-oncogene (zeige RAB1A ELISA Kits) with a potential role in both lymphoid and myeloid leukemogenesis
A subset of Bcl2 (zeige BCL2 ELISA Kits) family proteins are the targets of FGF-2 (zeige FGF2 ELISA Kits) signaling that promotes the survival of ATDC5 cells.
Demonstrate immunohistochemical expression of Wnt11 (zeige WNT11 ELISA Kits) and BCL2A1 in complete moles and normal villi.
Bfl-1 was mitochondrially resident in both resting and apoptotic cells and experienced regulation by the proteasome and NFkappaB pathways.
Bcl2a1 overexpressing granulocytic MDSCs demonstrated prolonged survival.
Results indicate that mismatches in minor H antigens HA-8 (KIAA0020) and ACC-1 (BCL2A1) predisposed to chronic graft-versus-host disease (GvHD).
BCL2A1 is a novel marker associated with seizure prognosis following surgery for low-grade brain neoplasms.
MITF (zeige MITF ELISA Kits)-BCL2A1 as a lineage-specific oncogenic pathway in melanoma and underscore its role for improved response to BRAF (zeige BRAF ELISA Kits)-directed therapy.
Mitochondrial antiapoptotic factor Bfl-1 is significantly reduced by suppressor of cytokine signaling (SOCS)1.
results highlight Bfl-1 as a major effector in activation-induced human mast cell survival
Data indicate that BCL2a1 expression enhances tumor cell survival in nervous system (CNS) leading to intracranial tumor growth.
a high-level expression of BCL2A1 in the conceptus at Day 21 of gestation, and it was expressed and increased in the extraembryonic membrane, cotyledon, and intercotyledon from implantation to term.
regulation of A1 and Bak (zeige BAK1 ELISA Kits) contribute to mitochondrial membrane stability, reduced caspase-9 (zeige CASP9 ELISA Kits) activity, and delayed apoptosis in bovine neutrophils exposed to glucocorticoids
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
bcl-2-related protein A1
, protein A1
, Bcl-2-like protein 5
, BCL2-related protein A1
, Bcl-2-related protein A1
, B-cell leukemia/lymphoma 2 related protein A1a
, hemopoietic-specific early response protein
, protein BFL-1
, bcl-2-like protein 5
, hematopoietic BCL2-related protein A1
, B-cell leukemia/lymphoma 2 related protein A1
, B-cell leukemia/lymphoma 2 related protein A1d
, BCL2-related protein A1d