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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death.
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Human Polyclonal BAG1 Primary Antibody für WB - ABIN2477577
Broström, Kronberg, Németh, Oxelbäck: The effect of shoulder muscle training in patients with recurrent shoulder dislocations. in Scandinavian journal of rehabilitation medicine 1992
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Human Polyclonal BAG1 Primary Antibody für WB - ABIN2477576
Liman, Ganesan, Dohm, Krajewski, Reed, Bähr, Wouters, Kermer: Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. in Molecular and cellular biology 2005
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Human Polyclonal BAG1 Primary Antibody für IHC, IHC (p) - ABIN4282935
Aust, Pils, Polterauer, Horvat, Cacsire Castillo-Tong, Pils, Dudek, Schmid, Speiser, Reinthaller, Grimm: Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer. in Applied immunohistochemistry & molecular morphology : AIMM 2013
Here the authors show that the AF-1 (zeige EFNA5 Antikörper) domain of AR is bound by the cochaperone Bag-1L.
Over expression of BAG-1 may be a biomarker for cisplatin resistance in patients with primary or recurrent head and neck squamous cell carcinoma.
Increased BAG-1 by PD-L1 (zeige CD274 Antikörper) confers resistance to tyrosine kinase (zeige TXK Antikörper) inhibitor in non-small cell lung cancer via persistent activation of ERK (zeige EPHB2 Antikörper) signaling.
BAG-4/SODD (zeige BAG4 Antikörper), HSP70 (zeige HSP70 Antikörper), and HSP90 (zeige HSP90 Antikörper) are potential prognostic markers in node-negative breast carcinoma that merit further research.
interaction with Bag1 then shifts hERG (zeige KCNH2 Antikörper) degradation to the membrane-anchored E3 ligase TRC8 (zeige RNF139 Antikörper) and its E2-conjugating enzyme Ube2g2 (zeige UBE2G2 Antikörper), as determined by siRNA screening
These results suggest that Bag1 and Bag3 (zeige BAG3 Antikörper) control the stability of the Hsc70 (zeige HSPA8 Antikörper)-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 (zeige HSPA8 Antikörper) system.
Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.
the combined effects of BAG-1 and XPD (zeige ERCC2 Antikörper) polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.
Bag-1 indirectly affects cell survival through c-Myc (zeige MYC Antikörper) activated signalling that causes elevation of ornithine decarboxylase (zeige ODC1 Antikörper) levels, leading to an increase of the polyamine content.
Overexpression of miR (zeige MLXIP Antikörper)-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.
These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions.
The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.
The membrane form of heparin binding EGF-like growth factor (zeige HBEGF Antikörper) (ProHB-EGF (zeige EGF Antikörper)) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.
Hemoxygenase (zeige HMOX1 Antikörper) 1 deficiency provoked diminished Bag-1 level upon LPS (zeige TLR4 Antikörper) treatment
this study first reported the solution structure of mBAG-1 (zeige LRRC4 Antikörper)-UBH and the growth factor precursor-interacting motif on the protein.
Bag-1 proteins function as regulators of the action of selective transcription factors.
during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)
Bag1 is a regulator and marker of neuronal differentiation
BAG1 displays potent neuroprotective activity in vivo against stroke.
Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
BAG family molecular chaperone regulator 1
, Bcl-2 associating athanogene-1 protein
, Bcl-2-binding protein
, glucocortoid receptor-associated protein RAP46
, receptor-associated protein, 46-KD
, bcl2-associated athanogene
, BCL2-associated athanogene
, bcl-2-associated athanogene 1
, hydroxysteroid (17-beta) dehydrogenase 3