anti-BCL2-Associated Athanogene (BAG1) Antikörper

Human BCL2-Associated Athanogene (BAG1) Interaktionspartner

1. Here the authors show that the AF-1 domain of AR is bound by the cochaperone Bag-1L.

2. Over expression of BAG-1 may be a biomarker for cisplatin resistance in patients with primary or recurrent head and neck squamous cell carcinoma.

3. Increased BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signaling.

4. BAG-4/SODD, HSP70, and HSP90 are potential prognostic markers in node-negative breast carcinoma that merit further research.

5. interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening

6. These results suggest that Bag1 and Bag3 control the stability of the Hsc70-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 system.

7. Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.

8. the combined effects of BAG-1 and XPD polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.

9. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.

10. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.

11. The expression of BAG-1 was upregulated in chronic non-eosinophilic rhinosinusitis.

12. BAG-1 expression was high in esophageal carcinoma tissues compared to normal esophagus. After Eca109 cells were transfected with BAG-1-siRNA, the proliferation and invasive capabilities of the cells were decreased while the apoptosis rate was enhanced.

13. BAG-1M mediates Hsp70 inhibition downstream of NF-kappaB.

14. Forced Bag-1L expression prevented Cisplatin-induced apoptosis.

15. distinct isoforms of BAG-1 had different anti-apoptotic ability in breast cancer cells treated with the 4-OH TAM.

16. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes

17. GARRPR in Bag-1L as a novel BF-3 regulatory sequence important for fine-tuning the activity of the AR

18. The results present that the constructed shRNA plasmids significantly inhibited the expression of mRNA and protein of Lo Vo cell BAG-1, and can maintain the effect for a long term

19. Bag1 is expressed at a higher level in functioning- compared to non-functioning pituitary adenomas.

20. we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2.

Mouse (Murine) BCL2-Associated Athanogene (BAG1) Interaktionspartner

1. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.

2. that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways

3. These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions.

4. The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.

5. The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.

6. Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment

7. this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein.

8. Bag-1 proteins function as regulators of the action of selective transcription factors.

9. during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)

10. Bag1 is a regulator and marker of neuronal differentiation

11. BAG1 displays potent neuroprotective activity in vivo against stroke.

12. Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.

13. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.

14. Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover

15. BAG-1 associates with Tau protein in an Hsc70-dependent manner.

16. BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments

17. These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain.

18. The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon.

19. Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons.