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BARX2 encodes a member of the homeobox transcription factor family.
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Barx2 and Pax7 (zeige PAX7 Antikörper) regulate the canonical Wnt (zeige WNT2 Antikörper) target gene Axin2 (zeige AXIN2 Antikörper), which mediates critical feedback to terminate the transcriptional response to Wnt (zeige WNT2 Antikörper) signals.
antagonism between Barx2 and Pax7 (zeige PAX7 Antikörper) in regulation of Wnt (zeige WNT2 Antikörper) signaling may help mediate the switch from myoblast proliferation to differentiation.
Barx2 is an important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation.
data suggest a functional network involving Barx2, Fgf10 (zeige FGF10 Antikörper) and matrix metalloproteinases that plays an essential role in regulating branching morphogenesis of the ocular glands.
Study show that Barx2 regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation.
Barx2 homeodomain factor serves as a regulator of hair follicle remodeling (catagen.
acts downstream of BMP signaling and in concert with Sox (zeige QSOX1 Antikörper) proteins to regulate chondrogenesis
BARX2 and estrogen receptor alpha (zeige ESR1 Antikörper) may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression.
Barx2 cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation.
these findings indicate that reduction or loss of Barx2 dis-inhibits gastric cancer cell proliferation and invasion, and that reduction in Barx2 could serve as an independent prognostic biomarker for poor outcome in gastric cancer patients
Down-regulation of Barx2 is associated with advanced clinical factors of colorectal cancer and predicts poor survival.
BARX2 can coordinate the expression of a network of genes that influence the growth of tumor cells
This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression.
BARX homeobox 2
, BarH-like homeobox 2
, homeobox protein BarH-like 2
, homeodomain transcription factor BARX2
, BARX homeobox 2, pseudogene 1
, Homeobox protein BarH-like 2
, homeobox transcription factor Barx2