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BTLA encodes a member of the immunoglobulin superfamily.
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The genetic variants of rs76844316 in BTLA influence the susceptibility to severe chronic hepatitis B and might play a protective role against the progression of chronic hepatitis B.
The impairment of Bregs and CD19 (zeige CD19 ELISA Kits)+/BTLA+ cells could play an important pathogenic role in multiple sclerosis (MS).
Our data portrays BTLA as a molecule with the singular ability to provide both costimulatory and coinhibitory signals to activated CD8 (zeige CD8A ELISA Kits)(+) T cells, resulting in extended survival, improved tumor control, and the development of a functional recall response.
results indicate that polymorphisms rs1982809 situated in 3' UTR (zeige UTS2R ELISA Kits) nearby region of BTLA gene might be considered as low-penetrating risk factor for RCC (zeige XRCC1 ELISA Kits), but results have to be confirmed in further studies
The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in patients with severe community acquired pneumonia.
Plasma concentrations of soluble BTLA were increased early in sepsis/septic shock and correlated to severity of disease. A baseline concentration >21ng/mL was associated with a poor prognosis.
this study shows that in chronic hepatitis B virus patients, a subset of inefficient interferon-gamma (zeige IFNG ELISA Kits) producing antigen-specific CD8 (zeige CD8A ELISA Kits)+ T cells recruited to the liver expressed high BTLA levels
this study shows that BTLA expression is likely associated with positive rather than conventional negative regulation of CD11c (zeige ITGAX ELISA Kits) antigen-presenting cell stimulatory capacity
rs1982809 BTLA gene polymorphism is associated with mRNA expression level and variations in the BTLA gene might be considered as potentially low-penetrating chronic lymphocytic leukemia risk factor
Study showed a decreased expression of BTLA in ocular Behcet's disease suggesting that it may be involved in the development and recurrence of this disease.
these data indicate that HVEM (zeige TNFRSF14 ELISA Kits)/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies following skin transplantation
The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in mice with LPS-induced acute lung inflammation.
Dendritic cells require BTLA and HVEM (zeige TNFRSF14 ELISA Kits) to actively adjust tolerizing T cell responses under steady-state conditions.
these data indicate that CCR7 (zeige CCR7 ELISA Kits) and BTLA cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7 (zeige CCR7 ELISA Kits)- or BTLA-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
this study shows that miR (zeige MLXIP ELISA Kits)-155 is involved in the inhibition of BTLA during CD4 (zeige CD4 ELISA Kits)+ T cell activation
Our findings indicate that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 (zeige FOXP3 ELISA Kits) expression, rather than attenuating IL-17 (zeige IL17A ELISA Kits) production, in dextran sulfate sodium-induced colitis.
This study uncovers a BTLA-mediated strategy used by the host that permits Listeria proliferation to enable increasing T cell responses for long-term protection.
results support a model whereby BTLA on innate leukocytes is triggered by HVEM (zeige TNFRSF14 ELISA Kits) and delivers negative signals into BTLA(+) cells, thereby interfering with the protective immune response to this intestinal parasite.
by coordinating expression of BTLA, RORgammat and IL-7 (zeige IL7 ELISA Kits) balance suppressive and activation stimuli to regulate gammadelta T cell homeostasis and inflammatory responses
BTLA promotes the pathogenesis of virus-induced fulminant hepatitis by enhancing macrophage viability and function. Targeting BTLA may be a novel strategy for the treatment of FH.
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis.
B and T lymphocyte associated
, B and T lymphocyte attenuator
, B- and T-lymphocyte attenuator
, B- and T-lymphocyte-associated protein