anti-Arylsulfatase A (ARSA) Antikörper

The protein encoded by ARSA hydrolyzes cerebroside sulfate to cerebroside and sulfate. Zusätzlich bieten wir Ihnen Arylsulfatase A Kits (38) und Arylsulfatase A Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ARSA 11883 P50428
ARSA 410 P15289
ARSA 315222  
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Top anti-Arylsulfatase A Antikörper auf antikoerper-online.de

Showing 10 out of 131 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, IHC, WB ABIN238536 (0.5µg/ml) staining of Mouse Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-ARSA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-ARSA Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-ARSA Picoband antibody, Western blotting All lanes: Anti ARSA  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Rat Pancreas Tissue Lysate at 50ug Lane 3: Rat Skeletal Muscle Tissue Lysate at 50ug Lane 4: Mouse Kidney Tissue Lysate at 50ug Lane 5: MCF-7 Whole Cell Lysate at 40ug Predicted bind size: 54KD Observed bind size: 54KD Anti-ARSA Picoband antibody,IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Arylsulfatase A staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Arylsulfatase A expression in HEK293T (A), mouse kidney (B), rat kidney (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB ABIN6274865 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of ARSA expression in Rat muscle lysate 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from Jurkat/COLO cells, using ARSA Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue, using ARSA Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: H1299 B: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$610.50
Details
Maus Kaninchen Unkonjugiert IP, ELISA, WB 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$218.90
Details

Am meisten referenzierte anti-Arylsulfatase A Antikörper

  1. Human Polyclonal Arylsulfatase A Primary Antibody für ELISA, IHC - ABIN238536 : Sevin, Benraiss, Van Dam, Bonnin, Nagels, Verot, Laurendeau, Vidaud, Gieselmann, Vanier, De Deyn, Aubourg, Cartier: Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy. in Human molecular genetics 2005 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen Arylsulfatase A Interaktionspartner

Mouse (Murine) Arylsulfatase A (ARSA) Interaktionspartner

  1. Multipotential Neural precursors deficient in arylsulfatase A show a higher ratio of long versus short fatty acid sulfatides, reduction in PDGFRa, decreased AKT phosphorylation, and increased exosomal shedding of PDGFRa.

  2. distributed not only on the cell surfaces of endothelial cells and hepatocytes, but also on the collagen fibrils in the space of Disse

  3. Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner.

  4. Sulfogalactosylglycerolipid was a physiological substrate of Sertoli lysosomal arylsulfatase A

  5. study provides the first proof of cognitive deficit and impaired synaptic plasticity in an MLD mouse model.

  6. ArsA plays a role as a novel component of the extracellular matrix which could be very useful for clarifying the mechanisms underlying some of the syndromes caused by functional deficiency of the Ars genes.

  7. Data demonstrate a delay in myelin formation in ASA-deficient mice at 2 weeks of age, as a consequence of inability to degrade sulfatide.

  8. Since high cholesterol levels are important for myelination, and various cellular processes, like vesicular trafficking and signal transduction, reduced cholesterol levels might be an important factor in the molecular pathology of MLD.

  9. ASA-deficient [ASA(-/-)] mice overexpressing the sulfatide synthesizing enzymes causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy

  10. The increasing sulfatide storage in ASA(-/-) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD.

  11. Safety of Arsa overexpression for gene therapy of metachromatic leukodystrophy was evaluated.

  12. Lysosomal AS-A may be involved in cell-surface remodeling during luteolysis by desulfating SGG after its endocytosis and targeting to the lysosome.

  13. Saposin B(Sap B) is not a limiting factor of the coupled Sap B-ASA reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels

Human Arylsulfatase A (ARSA) Interaktionspartner

  1. A novel homozygous missense mutation c.699C>A (p.His231Gln) in exon 4 of ARSA gene was identified in the three metachromatic leukodystrophy patients inherited from their heterozygous parents.

  2. The novel p.L113P mutation in a Pakistani family with late infantile MLD has a pathogenic and destructive effect on the protein structure and function of ARSA.

  3. siblings exhibited compound heterozygous variants {[c.302G>T]+[c.1344dupC]} in the ARSA gene, and both of the variants have been reported as disease-causing mutations previouslyfa

  4. First report of arylsulfatase A pseudodeficiency (ASA-PD) allele and haplotype frequencies in a North African population, reveals relatively high prevalence of the ASA-PD allele in the Tunisian population with an intermediate genetic structure between Africans, Middle-eastern and Europeans most probably linked to the particular geographic location of Tunisia and the several population incursions throughout its history

  5. an extensive review of all the ARSA-causative variants published in the literature to date, accounting for a total of 200 ARSA allele types (review)

  6. We report three families with Arylsulphatase A partial deficit in which we can find a high recurrence of parkinsonism among the siblings.

  7. Data indicate a significant correlation between the mutation of c.622delC(p.His208Metfs*46) in the arylsulfatase A (ARSA) gene and the phenotype OF metachromatic leukodystrophy.

  8. Sixteen novel mutations that cause metachromatic leukodystrophy have been identified in the arylsulfatase A gene.

  9. Arylsulphatase A activity in human endometrial polyps inversely correlates with aging

  10. Studied brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor.

  11. HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1.

  12. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction.

  13. This is the first report that human adipocytes express functional DAR and ARSA, suggesting a regulatory role for peripheral DA in adipose functions.

  14. The purpose was to estimate the birth prevalence of Metachromatic leukodystrophy in Poland by determining population frequency of the common pathogenic ARSA gene mutations and to compare this estimate with epidemiological data.

  15. The presence of two most common mutations associated with Arylsulfatase A pseudodeficiency was analyzed in 56 patients with diagnosis of relapsing-remitting multiple sclerosis, by polymerase chain reaction restriction fragment length polymorphism method.

  16. cationization of ASA and an increase of the mannose 6-phosphate content of the enzyme may promote blood-to-brain transfer of ASA, thus leading to an improved therapeutic efficacy of enzyme replacement therapy behind the BBB.

  17. ARSA mutations in the Indian population were characterized. 4 new variant & 5 pseudodeficiency alleles were found. Protein modeling showed loss of interactions leading to conformation change.

  18. case report of missense mutations p.G99D and p.T409I associated with adult-type metachromatic leukodystrophy

  19. contribution of mutations to enzyme activity reduction and metachromatic leukodystrophy severity

  20. analysis of arylsulfatase A mutations demonstrates a lack of association with Alzheimer-type dementia or Down syndrome

Pig (Porcine) Arylsulfatase A (ARSA) Interaktionspartner

  1. Cys69 was the active site residue, and Lys302 & Lys123 as residues anchoring the sulfate group of sulfogalactosylceramide/sulfogalactosylglycerolipid to the active site, as observed for nitrocatechol sulfate.

Arylsulfatase A (ARSA) Antigen-Profil

Protein Überblick

The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Genbezeichner und Symbole assoziert mit anti-Arylsulfatase A (ARSA) Antikörper

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Bezeichner auf Proteinebene für anti-Arylsulfatase A (ARSA) Antikörper

arylsulfatase A , Arylsulfatase A , cerebroside-sulfatase , ASA

GENE ID SPEZIES
458946 Pan troglodytes
541416 Danio rerio
716500 Macaca mulatta
1791590 Rhodopirellula baltica SH 1
1791953 Rhodopirellula baltica SH 1
1795188 Rhodopirellula baltica SH 1
1796341 Rhodopirellula baltica SH 1
1796692 Rhodopirellula baltica SH 1
1797062 Rhodopirellula baltica SH 1
100012344 Monodelphis domestica
100195737 Salmo salar
11883 Mus musculus
410 Homo sapiens
315222 Rattus norvegicus
474457 Canis lupus familiaris
396973 Sus scrofa
505514 Bos taurus
426863 Gallus gallus
100351118 Oryctolagus cuniculus
447252 Xenopus laevis
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