Arachidonate 5-Lipoxygenase (ALOX5) ELISA Kits

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Zusätzlich bieten wir Ihnen ALOX5 Antikörper (228) und ALOX5 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
ALOX5 240 P09917
ALOX5 11689 P48999
ALOX5 25290 P12527
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Top ALOX5 ELISA Kits auf

Showing 10 out of 41 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Lieferzeit Preis Details
Human 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests 13 bis 16 Tage
Ratte 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 13 bis 16 Tage
Maus 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests 13 bis 16 Tage
Kaninchen 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 bis 18 Tage
Meerschweinchen 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 bis 18 Tage
Schwein 0.094 ng/mL 0.156-10 ng/mL   96 Tests 12 bis 14 Tage
Affe 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 bis 18 Tage
  2 x 96 Tests 2 bis 3 Tage
Hund 0.1 ng/mL 0.5-10 ng/mL   96 Tests 15 bis 18 Tage
  96 Tests 15 bis 18 Tage

Am meisten referenzierte ALOX5 ELISA Kits

  1. Human ALOX5 ELISA Kit für Sandwich ELISA - ABIN832344 : van der Laan, Foroughi Asl, van den Borne, van Setten, van der Perk, van de Weg, Schoneveld, de Kleijn, Michoel, Björkegren, den Ruijter, Asselbergs, de Bakker, Pasterkamp: Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study. in Atherosclerosis 2015 (PubMed)

  2. Human ALOX5 ELISA Kit für Sandwich ELISA - ABIN414629 : Kapral, Wawszczyk, Sośnicki, Jesse, Węglarz: Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells. in Prostaglandins & other lipid mediators 2017 (PubMed)

Weitere ELISA Kits für ALOX5 Interaktionspartner

Human Arachidonate 5-Lipoxygenase (ALOX5) Interaktionspartner

  1. Human cytomegalovirus induced both COX-2 and 5-LO proteins but not transcripts in breast cancer.

  2. 5-LOX does not react with 5,15-diHpETE, although it can produce lipoxin A4 when 15-HpETE is the substrate. In contrast, both 12-LOX and 15-LOX-1 react with 5,15-diHpETE, forming specifically lipoxin B4.

  3. High lox5 expression is associated with dysmenorrhea.

  4. Our study showed that ALOX5 rs12762303 was associated with fasting blood glucose (FBG) levels but not with myocardial infarction in Chinese population

  5. ALOX5 rs4987105 polymorphism is associated with type 2 diabetes.

  6. PFN1 down-regulated the expression of lipoxygenase arachidonate 5-lipoxygenase (ALOX5) in human endometrial stromal cells and THP-1 macrophages.

  7. our work shows that ALOX5 plays a moderate anti-tumor role and functions as a drug sensitizer, with a therapeutic potential, in MLL-rearranged AML.

  8. Study shows that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Also, MiR-216a-3p was shown to directly bind to there 3'-UTR and inversely regulates their protein levels modulating CRC cell proliferation.

  9. Indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis.

  10. Our data reveal that 5-LO, which is required for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic cancer cells.

  11. the influence of TGFbeta/SMADs on MLL- and MLL-AF4-mediated 5-LO promoter activation

  12. The knockdown of arachidonate 5-lipoxygenase (Alox5) gene can induce the decreased levels of bcl/abl mRNA and BCR/ABL fusion protein in the K562/ADM cells and increased apoptosis rate.

  13. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.

  14. This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke.

  15. The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment

  16. ROS production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells.

  17. Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved

  18. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP.

  19. Polymorphisms in the 5-Lipoxygenase is associated with Incident Myocardial Infarction.

  20. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera

Mouse (Murine) Arachidonate 5-Lipoxygenase (ALOX5) Interaktionspartner

  1. that 5-lipoxygenase directly modulates tau phosphorylation at the same epitopes via the cdk5 kinase pathway

  2. Data show that the 5-Lipoxygenase knockout mice (5-LO(-/-) wounds had diminished mRNA expression in the skin lesions.

  3. Within the endothelial population, cells that transition from haemogenic endothelial to erythro-myeloid progenitors specifically express Alox5 and its co-factor Alox5ap, which control leukotriene production. Functional assays using mouse embryonic stem cells demonstrate that leukotrienes promote haematopoietic progenitor cell generation.

  4. neuronal 5LO is directly involved in tau phosphorylation and tau neuropathology.

  5. it was suggested that 5-LO in monocytes played a pivotal role in monocyte-macrophage differentiation and subsequent infiltration of macrophage in neointima, leading to vascular remodeling after vascular injury.

  6. the up-regulation of the ALOX5 is responsible for the Homocysteine-dependent worsening of the Alzheimer's disease phenotype in a relevant mouse model of the disease.

  7. Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.

  8. Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.

  9. Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.

  10. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL

  11. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera

  12. Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.

  13. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2, lipoxygenase and cyclooxygenase.

  14. Data suggest that miR-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6) or TNFa (tumor necrosis factor-alpha).

  15. Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.

  16. GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  17. SHH-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1-induced inflammatory cytokines.

  18. involvement of lipoxygenase pathways in TNF-alpha-induced production of cytokines and chemokines

  19. explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS or BALB/c mice and 5-LO-deficient mutants

  20. ALOX5 deficiency prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

Horse (Equine) Arachidonate 5-Lipoxygenase (ALOX5) Interaktionspartner

  1. [5-lipoxygenase; 5-lox] protein expression and enzyme activity of 5-LOX were significantly higher in horses harbouring encysted larvae in comparison with horses free of encysted larvae

  2. Increased PGE2 production led to reduction in 5-LO products in LPS-treated equine whole blood via IL-1b.

ALOX5 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ALOX5

  • arachidonate 5-lipoxygenase (ALOX5) Antikörper
  • arachidonate 5-lipoxygenase (Alox5) Antikörper
  • arachidonate 5-lipoxygenase a (alox5a) Antikörper
  • arachidonate 5-lipoxygenase (AFUA_4G02770) Antikörper
  • arachidonate 5-lipoxygenase (AOR_1_1362014) Antikörper
  • Arachidonate 5-lipoxygenase (lox5) Antikörper
  • 5-LO Antikörper
  • 5-LOX Antikörper
  • 5LO Antikörper
  • 5LPG Antikörper
  • 5LX Antikörper
  • AI850497 Antikörper
  • F730011J02 Antikörper
  • LOG5 Antikörper
  • lox5 Antikörper
  • LOX5A Antikörper
  • si:dkey-194n13.2 Antikörper

Bezeichner auf Proteinebene für ALOX5

LOX-5 , arachidonic 5-lipoxygenase alpha-10 isoform , arachidonic 5-lipoxygenase delta-10-13 isoform , arachidonic 5-lipoxygenase delta-13 isoform , arachidonic 5-lipoxygenase delta-p10 isoform , arachidonic acid 5-lipoxygenase , leukotriene A4 synthase , 5-lipoxygenase , 5 - Lipoxygenase , 5-LO , LOX2 , arachidonate 5-lipoxygenase , Arachidonate 5-lipoxygenase

240 Homo sapiens
11689 Mus musculus
25290 Rattus norvegicus
404074 Bos taurus
477753 Canis lupus familiaris
567204 Danio rerio
3503886 Aspergillus fumigatus Af293
5994193 Aspergillus oryzae RIB40
100194803 Salmo salar
100718093 Cavia porcellus
423769 Gallus gallus
100156205 Sus scrofa
100341714 Oryctolagus cuniculus
101117390 Ovis aries
101839970 Mesocricetus auratus
100062042 Equus caballus
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