Ankyrin Repeat Domain 27 (VPS9 Domain) Proteine (ANKRD27)

May be a Rab21 guanine exchange factor and regulate endosome dynamics.. Zusätzlich bieten wir Ihnen ANKRD27 Antikörper (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ANKRD27 84079 Q96NW4
ANKRD27 245886 Q3UMR0
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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ANKRD27 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Ankyrin Repeat Domain 27 (VPS9 Domain) (ANKRD27) Interaktionspartnern

Human Ankyrin Repeat Domain 27 (VPS9 Domain) (ANKRD27) Interaktionspartner

  1. VARP regulates endosomal trafficking and and retromer-mediated endosome-to-plasma membrane sorting of transmembrane proteins by binding to rab (zeige HRB Proteine) GTP-Binding (zeige RND2 Proteine) Proteins and R-SNARE (zeige YKT6 Proteine) VAMP7 (zeige VAMP7 Proteine) [review].

  2. Eosinophilic esophagitis was associate with increased expression of ANKRD27.

  3. VAMP7 (zeige VAMP7 Proteine)-SNARE (zeige NAPA Proteine) motif is trapped between Varp and the VAMP7 (zeige VAMP7 Proteine) longin domain, and hence Varp kinetically inhibits the ability of VAMP7 (zeige VAMP7 Proteine) to form SNARE (zeige NAPA Proteine) complexes

  4. Varp physically interacts with Rab38 (zeige RAB38 Proteine), and preferentially binds to the active GTP (zeige AK3 Proteine)-bound form of Rab38 (zeige RAB38 Proteine) both in vitro and in vivo.

  5. show that TI-VAMP (zeige VAMP7 Proteine) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp, a guanine nucleotide exchange factor (zeige RASGRF1 Proteine) of the small GTPase (zeige RACGAP1 Proteine) Rab21 (zeige RAB21 Proteine), through a specific domain herein called the interacting domain.

Mouse (Murine) Ankyrin Repeat Domain 27 (VPS9 Domain) (ANKRD27) Interaktionspartner

  1. RACK1 (zeige GNB2L1 Proteine) competes with Rab40C (zeige RAB40C Proteine) for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes

  2. both the Rab32 (zeige RAB32 Proteine)/38 binding activity and VAMP7 (zeige VAMP7 Proteine) binding activity of Varp are essential for trafficking of Tyrp1 (zeige TYRP1 Proteine) in melanocytes but activation of Rab21 (zeige RAB21 Proteine) by the VPS9 domain is not necessary for Tyrp1 (zeige TYRP1 Proteine) trafficking

  3. Varp is a potential Rab21 (zeige RAB21 Proteine) guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) and might regulate endosome dynamics in vivo

  4. Varp functions as the Rab32 (zeige RAB32 Proteine)/38 effector that controls trafficking of Tyrp1 (zeige TYRP1 Proteine) in melanocytes.

ANKRD27 Protein Überblick

Protein Überblick

May be a Rab21 guanine exchange factor and regulate endosome dynamics.

Genbezeichner und Symbole assoziert mit ANKRD27

  • ankyrin repeat domain 27 (ANKRD27)
  • ankyrin repeat domain 27 (VPS9 domain) (Ankrd27)
  • AA408090 Protein
  • BC016493 Protein
  • D330003H11Rik Protein
  • Varp Protein

Bezeichner auf Proteinebene für ANKRD27

VPS9 domain-containing protein , VPS9-ankyrin-repeat protein , Vps9 domain and ankyrin-repeat-containing protein , ankyrin repeat domain-containing protein 27 , VPS9-ankyrin repeat-containing protein , mFLJ00040 protein

GENE ID SPEZIES
84079 Homo sapiens
245886 Mus musculus
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