Angiogenin, Ribonuclease, RNase A Family, 5 (ANG) ELISA Kits

Human Angiogenin, Ribonuclease, RNase A Family, 5 (ANG) Interaktionspartner

1. ANG was highly expressed in normal eyes and normal trabecular meshwork cells compared to glaucomatous trabecular meshwork cells.

2. Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer.

3. Data show that higher levels of ANG observed in the pancreatic cancer microenvironment induce its binding to EGFR and activate EGFR signaling in an autocrine or paracrine manner which in turn promotes tumorigenesis and increases erlotinib sensitivity. These results identify a role of ANG as a serum biomarker that may be used to stratify patients for EGFR-targeted therapies.

4. In a hypoxic model of cell line ARPE-19, an increased expression level of ANG and induction of EMT accompanied with stabilization and nucleus translocation of HIF-1alpha. Blockage of HIF-1alpha signaling resulted in inhibition of high expression of ANG and EMT features.

5. Taken together, we hypothesize that PGRN A9D leads to the retention of ANG in the cytoplasm to protect cells from PGRN A9D-induced apoptosis, implying that PGRN and ANG act in concert to regulate the progress of neurodegenerative disease.

6. Angiogenin contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF).

7. Data show that phospholipase D2 (PLD2)-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (ccRCC) cells.

8. The results revealed that PCNA is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA colocalize in the cytoplasm, suggesting that they may interact in this compartment.

9. RNase 5 suppressed p27 and up-regulated cyclin D1, D3, and E by activating PI3-kinase/Akt in CECs to initiate cell cycle progression

10. When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy

11. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas

12. Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 through modulation of DNMT3b functions.

13. (31) RRR(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53-mediated apoptosis and angiogenesis in cancer cells.

14. Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.

15. Delivery of the therapeutic human genes VEGF and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5-VEGF+Ad5-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons.

16. Ang down-regulate the expression of Col-I, alpha-SMA and TGF-beta1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

17. Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review]

18. Results indicate that angiogenin (ANG) plays a critical role in regulating angiogenesis and follicle survival in xenografted human ovarian tissues.

19. we found that ANG plays an important role in EMT in squamous cell lung carcinoma and may be a valuable therapeutic target for squamous cell lung carcinoma

20. There is Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk.

Pig (Porcine) Angiogenin, Ribonuclease, RNase A Family, 5 (ANG) Interaktionspartner

1. Association analyses revealed the significant associations (P < 0.05) between the porcine ANG g. 149G>T polymorphism and mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean platelet volume (MPV) and platelet-large cell ratio (P-LCR).

Mouse (Murine) Angiogenin, Ribonuclease, RNase A Family, 5 (ANG) Interaktionspartner

1. A significant elevation of ANG expression level in a model of laser-induced choroidal neovascularization was demonstrated.

2. ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation.

3. angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth

4. Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis

5. RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.

6. ANG plays an important role in neurite pathfinding and this has implications for amyotrophic lateral sclerosis.

7. Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen.

8. All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT-induced PIN, indicating an essential role of ANG in AKT-mediated cell proliferation and survival.

9. Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 is sufficient and required to upregulate angiogenin expression during hypoxia.

Cow (Bovine) Angiogenin, Ribonuclease, RNase A Family, 5 (ANG) Interaktionspartner

1. This study is the first to demonstrate that hypoxia upregulates Ang1 expression via HIF2alpha-mediated transcriptional activation in pericytes, which plays a key role in angiogenesis.

2. rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infafrction.

3. bovine angiogenin is the substance mainly responsible for the inhibitory effect of bovine milk on osteoclast-mediated bone resorption