-
ANG was highly expressed in normal eyes and normal trabecular meshwork cells compared to glaucomatous trabecular meshwork cells.
-
Angiogenin and the MMP9-TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer.
-
Data show that higher levels of ANG observed in the pancreatic cancer microenvironment induce its binding to EGFR and activate EGFR signaling in an autocrine or paracrine manner which in turn promotes tumorigenesis and increases erlotinib sensitivity. These results identify a role of ANG as a serum biomarker that may be used to stratify patients for EGFR-targeted therapies.
-
In a hypoxic model of cell line ARPE-19, an increased expression level of ANG and induction of EMT accompanied with stabilization and nucleus translocation of HIF-1alpha. Blockage of HIF-1alpha signaling resulted in inhibition of high expression of ANG and EMT features.
-
Taken together, we hypothesize that PGRN A9D leads to the retention of ANG in the cytoplasm to protect cells from PGRN A9D-induced apoptosis, implying that PGRN and ANG act in concert to regulate the progress of neurodegenerative disease.
-
Angiogenin contributes to angiogenesis induced by Brain-derived neurotrophic factor (BDNF).
-
Data show that phospholipase D2 (PLD2)-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (ccRCC) cells.
-
The results revealed that PCNA is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA colocalize in the cytoplasm, suggesting that they may interact in this compartment.
-
RNase 5 suppressed p27 and up-regulated cyclin D1, D3, and E by activating PI3-kinase/Akt in CECs to initiate cell cycle progression
-
When yeast genetic interaction partners held in common between human OPTN and ANG were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy
-
There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas
-
Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 through modulation of DNMT3b functions.
-
(31) RRR(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53-mediated apoptosis and angiogenesis in cancer cells.
-
Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
-
Delivery of the therapeutic human genes VEGF and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5-VEGF+Ad5-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons.
-
Ang down-regulate the expression of Col-I, alpha-SMA and TGF-beta1/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.
-
Ang,Tie1 and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review]
-
Results indicate that angiogenin (ANG) plays a critical role in regulating angiogenesis and follicle survival in xenografted human ovarian tissues.
-
we found that ANG plays an important role in EMT in squamous cell lung carcinoma and may be a valuable therapeutic target for squamous cell lung carcinoma
-
There is Lack of association between the Angiogenin (ANG) rs11701 polymorphism and amyotrophic lateral sclerosis risk.