anti-Amyloid beta (Abeta) Antikörper

Abeta encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Zusätzlich bieten wir Ihnen beta Amyloid Proteine (3) und beta Amyloid Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
Abeta 351 P05067
Abeta 54226 P08592
Abeta 11820 P12023
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Top anti-beta Amyloid Antikörper auf

Showing 10 out of 176 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB 100 μg 5 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB Western blot analysis of Beta Amyloid expression in HEK293T (A), Hela (B) whole cell lysates. 200 μL 13 bis 14 Tage
Huhn Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Beta Amyloid (pT743) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of Beta Amyloid (pT743) expression in MCF7 colchicine-treated (A), mouse liver (B), PC12 (C) whole cell lysates. 200 μL 13 bis 14 Tage
Human Maus Unkonjugiert ELISA, IF, WB Fluorescent microscopy image (appotome) of 6 months-old APP/PS1 mouse hypocampus and somatosensory cortex. Double staining: in blue, nuclei DAPI staining. In red, Amyloid plaques. Immunofluorescence slices with the anti-amyloid beta antibody from different mouse genotypes. Wild type (WT), APP/PS1 and APP KO. In red, amyloid plaques. 100 μg 6 bis 7 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of Beta Amyloid expression in mouse kidney (A), mouse heart (B) whole cell lysates. 200 μL 13 bis 14 Tage
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB 0.1 mg 6 bis 8 Tage
Human Maus Unkonjugiert IHC, ELISA Abeta oligomer-specific antibody was adsorbed to Nunc-Immuno MaxiSorp plates (Nunc, Roskilde, Denmark) at 2 ug/ml in PBS. 1 ml of a 10 uM Aβ(1-42) sample containing a small fraction of Aβ-oligomers was separated using a superdex G75 (10/30) column. Aβ-fractions collected from the SEC were allowed to bind to OMAB plates for 20 minutes at 0°C. All fractions were analyzed and bound Aβ was detected using a polyclonal rabbit anti-Aβ antibody (ABIN249343) at a 1:1000 dilution followed by an anti-rabbit HRP-conjugated secondary antibody at a 1:5000 dilution (GE healthcare). ECBlue (Medicago, Uppsala, Sweden) was used as a substrate for HRP and the signal was detected by measuring the absorbance at 450 nm. Blocking solution and antibody-dilutions were made with 5% Non-fat dry milk in PBST and all washes were performed with PBS containing 0.1% Tween-20 (PBST). 10 µm of coronal sections from fresh-frozen transgenic mouse brain mutant (A) and wild type (B). Post-fixation in 4% formaldehyde solution, 5 min. OMAB antibody diluted 1:500, incubation at 4ºC ON. Mouse on mouse HRP-Polymer kit according to company instructions. Biocare Medical: BC-MM510 (Histolab) DAB substrate kit for peroxidase. Vector Laboratories: SK-4100 (ImmunKemi) Counterstained with Mayers HTX. 50 μg 6 bis 8 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL 11 bis 13 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using Amyloid-beta Polyclonal Antibody. 100 μL 11 bis 13 Tage
Human Maus Unkonjugiert IHC 100 μg 2 bis 3 Tage

Am meisten referenzierte anti-beta Amyloid Antikörper

  1. Human Monoclonal beta Amyloid Primary Antibody für ELISA, ICC - ABIN4284085 : Youmans, Tai, Kanekiyo, Stine, Michon, Nwabuisi-Heath, Manelli, Fu, Riordan, Eimer, Binder, Bu, Yu, Hartley, LaDu: Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. in Molecular neurodegeneration 2012 (PubMed)
    Show all 20 Pubmed References

  2. Human Monoclonal beta Amyloid Primary Antibody für ELISA, IF - ABIN5508784 : Markoutsa, Papadia, Clemente, Flores, Antimisiaris: Anti-Aβ-MAb and dually decorated nanoliposomes: effect of Aβ1-42 peptides on interaction with hCMEC/D3 cells. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012 (PubMed)
    Show all 4 Pubmed References

  3. Cow (Bovine) Polyclonal beta Amyloid Primary Antibody für ELISA, ICC - ABIN4284076 : He, Barrow: The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. in Biochemistry 1999 (PubMed)
    Show all 4 Pubmed References

  4. Human beta Amyloid Primary Antibody für ELISA (Capture), IF - ABIN1110165 : Levites, Jansen, Smithson, Dakin, Holloway, Das, Golde et al.: Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor ... in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 3 Pubmed References

  5. Fruit Fly (Drosophila melanogaster) Polyclonal beta Amyloid Primary Antibody für ELISA, ICC - ABIN4284077 : Youssef, Florent-Béchard, Malaplate-Armand, Koziel, Bihain, Olivier, Leininger-Muller, Kriem, Oster, Pillot: N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. in Neurobiology of aging 2008 (PubMed)
    Show all 3 Pubmed References

  6. Human beta Amyloid Primary Antibody für IF, IP - ABIN1110164 : Levites, Smithson, Price, Dakin, Yuan, Sierks, Kim, McGowan, Reed, Rosenberry, Das, Golde: Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)
    Show all 2 Pubmed References

  7. Human beta Amyloid Primary Antibody für ELISA (Capture), ELISA (Detection) - ABIN1110166 : Levites, Das, Price, Rochette, Kostura, McGowan, Murphy, Golde: Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. in The Journal of clinical investigation 2006 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal beta Amyloid Primary Antibody für IHC (fro), IHC (p) - ABIN2477631 : Romaguera, Grimalt, Vilaplana: Eczematous and purpuric allergic contact dermatitis from boots. in Contact dermatitis 1990 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal beta Amyloid Primary Antibody für IHC (fro), IHC (p) - ABIN2477628 : Axelsen, Holm, Birkelund, Christiansen, Ploug, Holm: Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody. in Molecular immunology 2009 (PubMed)

Weitere Antikörper gegen beta Amyloid Interaktionspartner

Human Amyloid beta (Abeta) Interaktionspartner

  1. These results suggest that Abeta could induce autophagy in RPE cells, which provided a potential protective mechanism for the retina cells that encountered Abeta deposition.

  2. This study found the L723P mutation to cause local unfolding of the C-terminal turn of the APP Transmembrane Domain helix and increase its accessibility to water required for cleavage of the protein backbone by gamma-secretase in the epsilon-site, thus switching between alternative ("pathogenic" and "non-pathogenic") cleavage cascades.

  3. Both wild-type and L-isoAsp23 protofilaments adopt beta-helix-like folds with tightly packed cores, resembling the cores of full-length fibrillar Abeta structures, and both self-associate through two distinct interfaces.

  4. There was no statistically significant difference in the levels of CSF A[beta]1-42 between the former athletes with multiple concussions group and healthy control group.

  5. The B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax (J20) mouse strain (#006293: Jackson Laboratory) carries a human APP695 transgene harboring the aggressive Swedish and Indiana substitutions. Sex-specific biochemical and behavioral phenotypes are observed in young human APP mice. Depression-like behavior does not align with cognitive deficits, particularly in very young, female hAPP mice.

  6. The present results suggested that APP knockdown may significantly inhibit the development of nasopharyngeal carcinoma by suppressing cell viability, migration and invasion, and by inhibiting the epithelialmesenchymal transition process via downregulation of the MAPK signaling pathway.

  7. These data provide valuable insights in understanding GRN-3's ability to modulate Abeta-induced toxicity under redox control and presents a new perspective toward AD pathology.

  8. In this study, the analytical capabilities of MALDI-TOF/TOF mass spectrometry for relative quantitation of isoAsp7 in ABETA (1-42) and ABETA(1-16) were investigated.

  9. oligomeric Abeta can profoundly disrupt the bilayer, visualized as widespread lipid extraction and subsequent deposition, which can be likened to an effect expected from the action of a detergent.

  10. The N-terminal sequence Xaa-Xaa-His is known as an amino terminal copper and nickel binding motif (ATCUN), which avidly binds Cu(II). Cu(II) bound to this particular ATCUN site is redox silent, but the second Cu(II) site is redox active and can be readily reduced with ascorbate.

  11. Thirteen of 148 (8.8%) individuals had possible pathogenic APP, PSEN1, or PSEN2 variants, including 2 (15.4%) APP variants, 8 (61.5%) PSEN1 variants, and 3 (23.1%) PSEN2 variants

  12. Synaptic dysfunction caused by presenilin-1 mutant and amyloid precusor protein duplication secretomes is mediated by Abeta peptides, whereas trisomy of chromosome 21 (trisomy 21) neuronal secretomes induce dysfunction through extracellular tau.

  13. In invasive cells, MT1-MMP endocytosis to the endolysosomal reservoir compartment requires flotillin 1 and flotillin 2.

  14. These data demonstrate a key role for proteolysis of the C-terminal of APP by gamma-secretase in neuronal dysfunction in monogenic Alzheimer's disease.

  15. a Drosophila Alzheimer's disease (AD) model expressing a secreted form of human amyloid-beta42 peptide showed that it recapitulates key aspects of AD pathology, including neuronal death and impaired long-term memory.

  16. Beta-amyloid peptide(1-42) (Abeta1-42) : phosphorylated Tau (p-Tau) ratio has potential for being implemented in the clinical routine for differential diagnosis between AD and other dementias and to distinguish underling pathology such as neurodegenerative disease.

  17. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.

  18. miR-346 plays a role in upregulation of APP in the CNS and participates in maintaining APP regulation of Fe, which is disrupted in late stages of AD.

  19. analysis of the interaction between monomeric Abeta40/42 and HSA using surface plasmon resonance spectroscopy

  20. Structural dynamics of dipeptides and ABETA (25-35) in aqueous solution were demonstrated

Mouse (Murine) Amyloid beta (Abeta) Interaktionspartner

  1. the present findings suggested that knockdown of Navb2 reversed the APP/PS1 mutationinduced deficiency in amyloid b degradation by regulating NEP.

  2. the contribution of cholinergic basal forebrain neuronal p75(NTR) to the progression of Alzheimer's disease (AD) by removing p75(NTR) from cholinergic neurons in the APP/PS1 familial AD mouse strain.

  3. Fe(3+) accelerates endocytic internalization of extracellular Abeta1-42, enhances Abeta1-42-induced caspase-3/caspase-4 activation.

  4. These findings provide insights into the therapeutic potential of non-amyloidogenic processing of APP in complex I-related neurodegeneration.

  5. show a novel function for Par3 in regulating polarized convergence between APP and BACE1 in hippocampal neurons

  6. Proteasome inhibition precludes APP axonal transport by enhancing its endo-lysosomal delivery, where beta-cleavage is induced.

  7. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.

  8. App(-/-) mice have higher levels of insulin-degrading enzyme (IDE) mRNA, protein, and activity. Regulation of IDE by APP was widespread across numerous tissues, including liver, skeletal muscle, and brain as well as cell types within neural tissue. App-/- mice failed to develop impairment of glucose tolerance on a high-fat, high-sucrose diet.

  9. The findings demonstrate that chronic noise exposure exacerbated Alzheimer's disease-like neuropathology, possibly by disrupting Wnt signaling and triggering aberrant tau hyperphosphorylation and amyloid beta peptides in the prefrontal cortex and hippocampus.

  10. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers.

  11. Together these data indicate that ONA induces APP expression and that gamma-secretase cleavage of APP releases AICD, which upregulates JNK3 leading to RGC death. This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma.

  12. In addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.

  13. These findings indicate that under physiological conditions, expression of APP in cerebral vascular endothelium plays an important protective function by maintaining constitutive expression of eNOS .

  14. NRBF2 plays an important role in regulating degradation of APP-C-terminal fragments through modulating autophagy.

  15. These results provide evidence that both central circadian rhythms and local clock function influence Abeta dynamics and plaque formation.

  16. These data identified APP and APLP2 as modulators of normal myelination and demyelination/remyelination conditions.

  17. these findings suggest that endogenous Abeta is involved in memory forgetting in the normal brain.

  18. pterostilbene attenuated the neuroinflammatory response induced by Abeta1-42 in microglia through inhibiting the NLRP3/caspase-1 inflammasome pathway, indicating that pterostilbene might be an effective therapy for AD.

  19. Abeta40 and Abeta42 demonstrated distinct distribution kinetics in plasma and brain compartments, and insulin differentially modulated their distribution.

  20. APP/GBR complex formation links presynaptic GBR trafficking to Abeta formation.

beta Amyloid (Abeta) Antigen-Profil

Protein Überblick

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Amyloid beta (Abeta) Antikörper

  • amyloid beta precursor protein (APP) Antikörper
  • amyloid beta precursor protein (app) Antikörper
  • amyloid beta precursor protein (App) Antikörper
  • amyloid beta (A4) precursor protein (App) Antikörper
  • aaa Antikörper
  • Abeta Antikörper
  • Abpp Antikörper
  • ad1 Antikörper
  • Adap Antikörper
  • Ag Antikörper
  • appi Antikörper
  • betaApp Antikörper
  • ctfgamma Antikörper
  • Cvap Antikörper
  • E030013M08Rik Antikörper
  • PN-II Antikörper
  • pn2 Antikörper

Bezeichner auf Proteinebene für anti-Amyloid beta (Abeta) Antikörper

alzheimer disease amyloid protein , amyloid beta A4 protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid A4 protein homolog , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , ABPP , AG , amyloid A4 , amyloidogenic glycoprotein , appican , protease nexin II

351 Homo sapiens
448208 Xenopus (Silurana) tropicalis
100427716 Macaca mulatta
54226 Rattus norvegicus
11820 Mus musculus
Ausgewählte Anbieter für anti-beta Amyloid (Abeta) Antikörper
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