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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)..
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Human Polyclonal ALKBH5 Primary Antibody für IHC, IHC (p) - ABIN4279674
Zhang, Samanta, Lu, Bullen, Zhang, Chen, He, Semenza: Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. in Proceedings of the National Academy of Sciences of the United States of America 2016
Show all 2 Pubmed References
N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A (zeige GPM6A Antikörper)-recognising proteins, including FTO (zeige FTO Antikörper) and ALKBH5.
ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice
ALKBH5-FOXM1 (zeige FOXM1 Antikörper) pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients.
HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment
The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.
Structures of human ALKBH5 demethylase (zeige MBD2 Antikörper) reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms.
findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB (zeige ALKBH Antikörper) members
ALKBH5 is a RNA demethylase (zeige MBD2 Antikörper) and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells.
ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene
This study identified reversible m6A (zeige GPM6A Antikörper) modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic and haploid spermatogenic cells.
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
RNA demethylase ALKBH5
, alkylated DNA repair protein alkB homolog 5
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
, probable alpha-ketoglutarate-dependent dioxygenase ABH5
, oxoglutarate and iron-dependent oxygenase domain containing