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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma.
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Data indicate lysine acetyltransferase 2B (KAT2B (zeige KAT2B Antikörper)) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma) protein (ADD3)-associated disorders.
MiR (zeige MLXIP Antikörper)-145-5p was confirmed to target ADD3 by luciferase reporter assay. The downregulation of miR (zeige MLXIP Antikörper)-145 may contribute to liver fibrosis in Biliary atresia by upregulating the expression of ADD3.
ADD3 gene deletion is associated with acute lymphoblastic leukemia.
ADD3 gene plays an important role in biliary atresia pathogenesis.
Common genetic variants in 10q24.2 can alter biliary atresia risk by regulating ADD3 expression levels in the liver, and may exert an effect on disease epidemiology and on the general population.
High expression of ADD3 is associated with glioma.
ADD3 gene may be functionally relevant for the development of biliary atresia
Homozygous p.G367D mutation in ADD3 causes spastic diplegic/quadriplegic cerebral palsy and intellectual disability.
gamma-adducin may influence blood pressure homeostasis by modulating renal NaCl transport.
The interaction of ADD1 (zeige ADD1 Antikörper) and ADD3 gene variants in humans is statistically associated with variation in blood pressure, suggesting the presence of epistatic effects among these loci.
C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH (zeige POMC Antikörper) vesicles.
Targeted deletion of alpha-adducin (zeige ADD1 Antikörper) results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 (zeige CD44 Antikörper) and RHAMM (zeige HMMR Antikörper)-mediated signalling pathways involving Cdc2 (zeige CDK1 Antikörper) and gamma-adducin.
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.
, adducin 3 (gamma)
, adducin 3 gamma
, adducin-like protein 70
, cytoskeletal protein
, potein kinase C binding protein 35H
, protein kinase C-binding protein 35H