Activin A Receptor Type II-Like 1 Proteine (ACVRL1)

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. Zusätzlich bieten wir Ihnen ACVRL1 Antikörper (173) und ACVRL1 Kits (30) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ACVRL1 94 P37023
ACVRL1 25237 P80203
ACVRL1 11482 Q61288
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Showing 10 out of 26 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Maus Fc Tag,His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Hund Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Ratte Fc Tag,His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Human Cells Cynomolgus Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
HEK-293 Cells Human His tag Human ALK-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$286.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Mammalian Cells Maus Fc Tag   50 μg Anmelden zum Anzeigen 4 Days
$158.13
Details

ACVRL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , , ,
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Weitere Proteine zu Activin A Receptor Type II-Like 1 (ACVRL1) Interaktionspartnern

Cow (Bovine) Activin A Receptor Type II-Like 1 (ACVRL1) Interaktionspartner

  1. Results show that ALK5 (zeige TGFBR1 Proteine) and ALK1 play antagonistic roles in TGF-beta (zeige TGFB1 Proteine)-induced podosome formation in aortic endothelial cells.

  2. ALK1 and ALK5 (zeige TGFBR1 Proteine) are both essential for correct regulation of VEGF (zeige VEGFA Proteine), and that disruption of either pathway leads to disease.

Zebrafish Activin A Receptor Type II-Like 1 (ACVRL1) Interaktionspartner

  1. alk1 loss has no effect on arterial endothelial cell proliferation but alters arterial endothelial cell migration within lumenized vessels.

  2. Control of Notch (zeige NOTCH1 Proteine) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (zeige NOTCH1 Proteine) and Alk1

  3. Blood flow is required not only for alk1 expression but also for Alk1 activity.

  4. Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.

  5. vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (zeige TGFB1 Proteine) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.

Human Activin A Receptor Type II-Like 1 (ACVRL1) Interaktionspartner

  1. We have identified a novel role for ALK1 in cardiac remodeling

  2. The present study showed that deletion-duplication mutations in the BMPR2 (zeige BMPR2 Proteine) or ACVRL1 genes may not be associated with non-regression of Pulmonary arterial hypertension.

  3. Study identified 2 non-synonymous missense mutations: c.C652T, p.R218W in ACVRL1, c.C717G, p.D239E in SGCD (zeige SGCD Proteine) in Chinese population with total anomalous pulmonary venous return.

  4. Mutations in ACVRL1 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension.

  5. Treatment-related telangiectasia was noted in 7% of patients, suggesting in vivo inhibition of the ALK-1 pathway.

  6. Data indicate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 and VEGFR (zeige KDR Proteine), is a valid strategy for treatment of metastatic renal cell carcinoma (zeige MOK Proteine) (mRCC).

  7. Study showed that rs706819, rs2293094, and rs11169953 polymorphisms in the ACVRL1 gene are associated with higher susceptibility to brain arteriovenous malformations.

  8. c.1027C > T(p.Gln343) mutation within the ACVRL1 gene in family with hereditary hemorrhagic telangiectasia

  9. Bone morphogenetic protein (BMP)9 (zeige GDF2 Proteine) and BMP10 (zeige BMP10 Proteine) are high affinity ligands for activin receptor-like kinase 1 (ALK1).

  10. Activin receptor-like kinase (ALK)1 is a transforming growth factor beta (TGF-beta) type I receptor (zeige TGFBR1 Proteine) predominantly expressed in actively proliferating endothelial cells (ECs).

Mouse (Murine) Activin A Receptor Type II-Like 1 (ACVRL1) Interaktionspartner

  1. We have identified a novel role for ALK1 in cardiac remodeling

  2. Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng (zeige ENG Proteine)) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

  3. Global deletion of AlK-1 is associated with the development of high output heart failure without maladaptive remodeling.

  4. These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF (zeige VEGFA Proteine). Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.

  5. these studies characterize an accessory TGF-beta (zeige TGFB1 Proteine)-stimulated BMP R-Smad (zeige SMAD1 Proteine) signaling mechanism in interstitial cells of the developing lung.

  6. this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development.

  7. CD109 (zeige CD109 Proteine) differentially regulates TGF-beta (zeige TGFB1 Proteine)-induced ALK1-Smad1 (zeige SMAD1 Proteine)/5 versus ALK5 (zeige TGFBR1 Proteine)-Smad2 (zeige SMAD2 Proteine)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (zeige CD109 Proteine) expression regulates dermal function through a paracrine mechanism

  8. he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 signaling pathways in the cell

  9. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.

  10. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

ACVRL1 Protein Überblick

Protein Überblick

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Genbezeichner und Symbole assoziert mit ACVRL1

  • activin A receptor like type 1 (ACVRL1)
  • activin A receptor type II-like 1 (ACVRL1)
  • activin A receptor like type 1 (acvrl1)
  • activin A receptor like type 1 (Acvrl1)
  • activin A receptor, type II-like 1 (Acvrl1)
  • ACVRL1 Protein
  • Acvrlk1 Protein
  • AI115505 Protein
  • AI427544 Protein
  • ALK-1 Protein
  • Alk1 Protein
  • HHT Protein
  • HHT2 Protein
  • hm:zehn1109 Protein
  • ORW2 Protein
  • R-3 Protein
  • R3 Protein
  • SETHKIR Protein
  • SKR3 Protein
  • TSR-I Protein
  • vgb Protein
  • zehn1109 Protein

Bezeichner auf Proteinebene für ACVRL1

activin A receptor type II-like 1 , serine/threonine-protein kinase receptor R3 , serine/threonine-protein kinase receptor R3-like , activin receptor-like kinase 1 , vbg , violet beauregarde , TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 1 , Activin receptor like kinase 1 , SKR3 , TSR-I , ALK-1 , activin receptor-like kinase-1

GENE ID SPEZIES
451910 Pan troglodytes
534536 Bos taurus
696471 Macaca mulatta
100061313 Equus caballus
100135773 Felis catus
100482358 Ailuropoda melanoleuca
266753 Danio rerio
94 Homo sapiens
25237 Rattus norvegicus
477603 Canis lupus familiaris
100153279 Sus scrofa
100172614 Pongo abelii
11482 Mus musculus
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