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3'-5' DNA helicase involved in repair of alkylated DNA. Zusätzlich bieten wir Ihnen ASCC3 Kits (4) und und viele weitere Produktgruppen zu diesem Protein an.
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UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3.
ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B.
Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses.
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (By similarity).
helicase, ATP binding 1
, ASC-1 complex subunit P200
, RNA helicase family
, trip4 complex subunit p200