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3'-5' DNA helicase involved in repair of alkylated DNA.
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Human Polyclonal ASCC3 Primary Antibody für ICC, IF - ABIN4281842
Armstrong, Healy, Halabi, Vollmer, Lark, Kemeny, Ware, Freedland: Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. in Prostate cancer and prostatic diseases 2016
UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3.
ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B.
Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon (zeige IFNA Antikörper)-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses.
DNA unwinding by ASCC3 helicase is coupled to ALKBH3 (zeige ALKBH3 Antikörper)-dependent DNA alkylation repair and cancer cell proliferation.
3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation (By similarity).
helicase, ATP binding 1
, ASC-1 complex subunit P200
, RNA helicase family
, trip4 complex subunit p200