This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Genbezeichner und Symbole assoziert mit ASCC1
activating signal cointegrator 1 complex subunit 1 (ascc1) Antikörper
activating signal cointegrator 1 complex subunit 1 (ASCC1) Antikörper
activating signal cointegrator 1 complex subunit 1 (Ascc1) Antikörper