ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (290) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ABCB1 5243 P08183
Ratte ABCB1 ABCB1 170913  
Maus ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine auf antikoerper-online.de

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 70 bis 75 Tage
$16,301.58
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$504.90
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Hefe REACT_Entamoeba histolytica His tag   500 μg Anmelden zum Anzeigen 60 bis 71 Tage
$962.50
Details

ABCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Am meisten referenzierte ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

Weitere Proteine zu ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartnern

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. High MDR1 expression is associated with primary myelodysplastic syndrome.

  2. analysis of the structure of zosuquidar and UIC2-bound human-mouse chimeric ABCB1

  3. ABCB1 gene polymorphisms are not associated with response to chemotherapy in breast cancer.

  4. Patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05).

  5. Genotypes of UGT1A (zeige UGT1A1 Proteine) and ABCB1 were significantly associated with changes in moxifloxacin pharmacokinetic parameters.

  6. G2677T/A polymorphism of MDR1 may play a significant role in the development of drug-resistant epilepsy in the Polish patients

  7. No association was found between the ABCB1 SNPs and Crohn's disease in the two populations

  8. icaritin (ICT) decreased the mRNA and protein levels of multidrug resistance protein 1 (MDR1 (zeige ABCB4 Proteine)) in MG-63 doxorubicin-resistant (MG-63/DOX) cells.

  9. We demonstrate for the first time that the effect of ABCB1 diplotype on tacrolimus disposition is dependent on both CYP3A5 (zeige CYP3A5 Proteine) and CYP3A4 (zeige CYP3A4 Proteine) genotype.

  10. these results address key concerns in the field, including that of cross-resistance between taxanes and highlighting a mechanism of cabazitaxel resistance involving ABCB1

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. A panel of 18 P-gp (zeige ABCB4 Proteine) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (zeige ABCB4 Proteine)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (zeige ABCB4 Proteine) can affect the pulmonary kinetics of a subset of P-gp (zeige ABCB4 Proteine) substrates.

  2. Data suggest that the overexpression of P-gp (zeige ABCB4 Proteine) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  3. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  4. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Proteine), multi-drug resistance protein, MDR1 (zeige ABCB4 Proteine)).Drugs with ER < 1 (zeige MIER1 Proteine) almost do not bind the main binding cavity (MBC (zeige CACNA1C Proteine)) of P-gp (zeige ABCB4 Proteine).

  5. conclusion, MDR1 (zeige ABCB4 Proteine) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Proteine)-II layer.

  6. Mdr1 (zeige ABCB4 Proteine) enforces T Cell homeostasis in the presence of intestinal bile acids.

  7. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  8. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  9. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  10. Chrysosplenetin inhibited P-gp (zeige ABCB4 Proteine) activity and reverse the up-regulated P-gp (zeige ABCB4 Proteine) and MDR1 (zeige ABCB4 Proteine) levels induced by artemisinin.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Überblick

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Genbezeichner und Symbole assoziert mit ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ABC20 Protein
  • ABCB1 Protein
  • CD243 Protein
  • CLCS Protein
  • GP170 Protein
  • mdr Protein
  • Mdr1 Protein
  • Mdr1a Protein
  • Mdr1b Protein
  • p-gp Protein
  • PGP1 Protein
  • Pgy-1 Protein
  • Pgy1 Protein
  • xemdr Protein

Bezeichner auf Proteinebene für ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

GENE ID SPEZIES
5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
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