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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (258) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.
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Human ABCB1 Protein expressed in Wheat germ - ABIN1305435
Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008
The role of multidrug resistance 1 gene (MDR1 or ABCB1) polymorphism G2677T was studied in relation to paroxetine therapeutic efficacy and its side effects, as well as its association with selected demographic and clinical characteristics of patients with depressive disorder.
alterations in latrophilin expression occur in AML (zeige RUNX1 Proteine) cells expressing P-gp (zeige ABCB4 Proteine)
This study demonstrated that the The G2677T T and C3435T T alleles as well as the TT, CTT (zeige TNNT2 Proteine) and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in Tunisian epileptic population.
Pharmacokinetics of aripiprazole is affected by sex and ABCB1 gene phenotype
There were no significant differences in the bosutinib C0 between genotypes for ABCB1, ABCG2, and CYP3A4 (zeige CYP3A4 Proteine) polymorphisms.
Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG (zeige UGCG Proteine)) and multidrug resistance protein 1 (MDR1 (zeige ABCB4 Proteine)) overexpression and multidrug resistance development [Review].
Due to the downregulation of MDR1 and MRP1 (zeige MDM4 Proteine), the intracellular accumulation of ADM (zeige ADM Proteine) was increased in the transfected cells compared with that in the parental K562/ADM (zeige ADM Proteine) cells..Our research revealed that protein expression of the ERK (zeige EPHB2 Proteine) signaling pathway was inhibited by downregulating TRIB2 (zeige TRIB2 Proteine), indicating that the ERK (zeige EPHB2 Proteine) pathway was involved in cell drug resistance and proliferation.
Asiatic Acid strongly inhibited P-GP (zeige ABCB4 Proteine) expression by blocking MDR1 gene transcription and increased the intracellular accumulation of the P-GP (zeige ABCB4 Proteine) substrate Rhodamine 123 in MDR1-overexpressing cisplatin (DDP (zeige TIMM8A Proteine))-resistant lung cancer cells, A549/DDP (zeige TIMM8A Proteine).
Ceritinib enhanced the efficacy of substrate chemotherapeutic agent in ABCB1-overexpressing K562/adr (zeige AKR1B1 Proteine) leukemia cells both in vitro and in vivo models, but neither in sensitive parental K562 leukemia cells nor in ABCC1 (zeige ABCC1 Proteine)-overexpressing HL-60/adr (zeige AKR1B1 Proteine) leukemia cells.
Polymorphism of ABCB1 rs1045642-T variant allele is associated with colorectal cancer.
P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
this study shows that MDR1 (zeige ABCB4 Proteine) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (zeige ABCB4 Proteine) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (zeige ABCB4 Proteine)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (zeige ABCB4 Proteine) can affect the pulmonary kinetics of a subset of P-gp (zeige ABCB4 Proteine) substrates.
Data suggest that the overexpression of P-gp (zeige ABCB4 Proteine) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Proteine), multi-drug resistance protein, MDR1 (zeige ABCB4 Proteine)).Drugs with ER < 1 (zeige MIER1 Proteine) almost do not bind the main binding cavity (MBC (zeige CACNA1C Proteine)) of P-gp (zeige ABCB4 Proteine).
conclusion, MDR1 (zeige ABCB4 Proteine) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Proteine)-II layer.
Mdr1 (zeige ABCB4 Proteine) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B