Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (281) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
Showing 5 out of 7 products:
Human ABCB1 Protein expressed in Wheat germ - ABIN1305435
Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008
No statistically significant correlations for the other nine haplotypes were found. Presented results concerning the relationship of ABCB1 polymorphisms with susceptibility to systemic sclerosis are the first ones that were obtained in a Polish population. They imply that single nucleotide polymorphisms do not affect the risk for SSc (zeige CYP11A1 Proteine), but the 1236 C-2677 G-3435 T haplotype might increase this risk.
Results suggested that the rs1045642-T allele of the ABCB1 gene may be associated with increased risk for renal function injury in hypertensive patients.
Established is an MDCK cell line stably overexpressing the human MDR1 transporter. CRISPR-Cas9 gene editing was used to knockout the endogenous cMDR1. Application of this cell line allowed unbiased reclassification of drugs previously defined as both substrates and non-substrates in different studies using commonly used MDCK-MDR1 clones.
These results suggest that the established models can predict brain exposure from the respective blood concentration-time profiles and rank the magnitude of the Pgp-mediated brain drug-drug interaction potential for both Pgp and Pgp/BCRP substrates in humans.
ABCB1 polymorphisms are factors influencing the pharmacokinetics of oseltamivir in the body.
Astragaloside IV reversed the drug resistance of Bel7402/FU cells by downregulating the expression of mdr1 via inhibition of the JNK (zeige MAPK8 Proteine)/cJun/AP1 (zeige JUN Proteine) signaling pathway.
results of the present study indicate that the G2677T/A polymorphism in the ABCB1 gene may affect the risk of developing bullous pemphigoid (zeige DST Proteine)
This study suggests that pre-treatment with miR (zeige MLXIP Proteine)-495 before chemotherapy could improve the curative effect on MDR1-based multidrug resistance cancer.
C1236T and C3435T polymorphisms in MDR1 gene and trough levels significantly influence the risk of cytogenetic relapse. MDR1-C3435T genotype might emerge as a potential biomarker to predict the risk of cytogenetic relapse in patients with CML.
we found that the expression of P-gp (zeige ABCB4 Proteine) in primary MM cells derived from the bone marrow of MM patients was correlated to the hypoxic status of these cells, and that hypoxia induced P-gp (zeige ABCB4 Proteine) expression in MM cells in vitro. We further found that the hypoxia-induced resistance to bortezomib and carfilzomib in MM was reversed by pharmacological inhibition of P-gp (zeige ABCB4 Proteine) by tariquidar.
P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
Data suggest that the overexpression of P-gp (zeige ABCB4 Proteine) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Proteine), multi-drug resistance protein, MDR1 (zeige ABCB4 Proteine)).Drugs with ER < 1 (zeige MIER1 Proteine) almost do not bind the main binding cavity (MBC (zeige CACNA1C Proteine)) of P-gp (zeige ABCB4 Proteine).
conclusion, MDR1 (zeige ABCB4 Proteine) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Proteine)-II layer.
Mdr1 (zeige ABCB4 Proteine) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 Proteine) activity and reverse the up-regulated P-gp (zeige ABCB4 Proteine) and MDR1 (zeige ABCB4 Proteine) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 Proteine) gene expression and activity in an enantiomer-specific way.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B