ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (258) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ABCB1 5243 P08183
Ratte ABCB1 ABCB1 170913  
Maus ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine auf

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 70 bis 75 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Hefe REACT_Entamoeba histolytica His tag   500 μg Anmelden zum Anzeigen 60 bis 71 Tage

ABCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Am meisten referenzierte ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

Weitere Proteine zu ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartnern

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. The role of multidrug resistance 1 gene (MDR1 or ABCB1) polymorphism G2677T was studied in relation to paroxetine therapeutic efficacy and its side effects, as well as its association with selected demographic and clinical characteristics of patients with depressive disorder.

  2. alterations in latrophilin expression occur in AML (zeige RUNX1 Proteine) cells expressing P-gp (zeige ABCB4 Proteine)

  3. This study demonstrated that the The G2677T T and C3435T T alleles as well as the TT, CTT (zeige TNNT2 Proteine) and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in Tunisian epileptic population.

  4. Pharmacokinetics of aripiprazole is affected by sex and ABCB1 gene phenotype

  5. There were no significant differences in the bosutinib C0 between genotypes for ABCB1, ABCG2, and CYP3A4 (zeige CYP3A4 Proteine) polymorphisms.

  6. Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG (zeige UGCG Proteine)) and multidrug resistance protein 1 (MDR1 (zeige ABCB4 Proteine)) overexpression and multidrug resistance development [Review].

  7. Due to the downregulation of MDR1 and MRP1 (zeige MDM4 Proteine), the intracellular accumulation of ADM (zeige ADM Proteine) was increased in the transfected cells compared with that in the parental K562/ADM (zeige ADM Proteine) cells..Our research revealed that protein expression of the ERK (zeige EPHB2 Proteine) signaling pathway was inhibited by downregulating TRIB2 (zeige TRIB2 Proteine), indicating that the ERK (zeige EPHB2 Proteine) pathway was involved in cell drug resistance and proliferation.

  8. Asiatic Acid strongly inhibited P-GP (zeige ABCB4 Proteine) expression by blocking MDR1 gene transcription and increased the intracellular accumulation of the P-GP (zeige ABCB4 Proteine) substrate Rhodamine 123 in MDR1-overexpressing cisplatin (DDP (zeige TIMM8A Proteine))-resistant lung cancer cells, A549/DDP (zeige TIMM8A Proteine).

  9. Ceritinib enhanced the efficacy of substrate chemotherapeutic agent in ABCB1-overexpressing K562/adr (zeige AKR1B1 Proteine) leukemia cells both in vitro and in vivo models, but neither in sensitive parental K562 leukemia cells nor in ABCC1 (zeige ABCC1 Proteine)-overexpressing HL-60/adr (zeige AKR1B1 Proteine) leukemia cells.

  10. Polymorphism of ABCB1 rs1045642-T variant allele is associated with colorectal cancer.

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. this study shows that MDR1 (zeige ABCB4 Proteine) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  2. A panel of 18 P-gp (zeige ABCB4 Proteine) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (zeige ABCB4 Proteine)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (zeige ABCB4 Proteine) can affect the pulmonary kinetics of a subset of P-gp (zeige ABCB4 Proteine) substrates.

  3. Data suggest that the overexpression of P-gp (zeige ABCB4 Proteine) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  4. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  5. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Proteine), multi-drug resistance protein, MDR1 (zeige ABCB4 Proteine)).Drugs with ER < 1 (zeige MIER1 Proteine) almost do not bind the main binding cavity (MBC (zeige CACNA1C Proteine)) of P-gp (zeige ABCB4 Proteine).

  6. conclusion, MDR1 (zeige ABCB4 Proteine) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Proteine)-II layer.

  7. Mdr1 (zeige ABCB4 Proteine) enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  9. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  10. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Überblick

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Genbezeichner und Symbole assoziert mit ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ABC20 Protein
  • ABCB1 Protein
  • CD243 Protein
  • CLCS Protein
  • GP170 Protein
  • mdr Protein
  • Mdr1 Protein
  • Mdr1a Protein
  • Mdr1b Protein
  • p-gp Protein
  • PGP1 Protein
  • Pgy-1 Protein
  • Pgy1 Protein
  • xemdr Protein

Bezeichner auf Proteinebene für ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
Ausgewählte Anbieter für ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (ABCB1)
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