ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (281) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ABCB1 5243 P08183
Ratte ABCB1 ABCB1 170913  
Maus ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine auf

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 70 bis 75 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Hefe REACT_Entamoeba histolytica His tag   500 μg Anmelden zum Anzeigen 60 bis 71 Tage

ABCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Am meisten referenzierte ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

Weitere Proteine zu ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartnern

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. No statistically significant correlations for the other nine haplotypes were found. Presented results concerning the relationship of ABCB1 polymorphisms with susceptibility to systemic sclerosis are the first ones that were obtained in a Polish population. They imply that single nucleotide polymorphisms do not affect the risk for SSc (zeige CYP11A1 Proteine), but the 1236 C-2677 G-3435 T haplotype might increase this risk.

  2. Results suggested that the rs1045642-T allele of the ABCB1 gene may be associated with increased risk for renal function injury in hypertensive patients.

  3. Established is an MDCK cell line stably overexpressing the human MDR1 transporter. CRISPR-Cas9 gene editing was used to knockout the endogenous cMDR1. Application of this cell line allowed unbiased reclassification of drugs previously defined as both substrates and non-substrates in different studies using commonly used MDCK-MDR1 clones.

  4. These results suggest that the established models can predict brain exposure from the respective blood concentration-time profiles and rank the magnitude of the Pgp-mediated brain drug-drug interaction potential for both Pgp and Pgp/BCRP substrates in humans.

  5. ABCB1 polymorphisms are factors influencing the pharmacokinetics of oseltamivir in the body.

  6. Astragaloside IV reversed the drug resistance of Bel7402/FU cells by downregulating the expression of mdr1 via inhibition of the JNK (zeige MAPK8 Proteine)/cJun/AP1 (zeige JUN Proteine) signaling pathway.

  7. results of the present study indicate that the G2677T/A polymorphism in the ABCB1 gene may affect the risk of developing bullous pemphigoid (zeige DST Proteine)

  8. This study suggests that pre-treatment with miR (zeige MLXIP Proteine)-495 before chemotherapy could improve the curative effect on MDR1-based multidrug resistance cancer.

  9. C1236T and C3435T polymorphisms in MDR1 gene and trough levels significantly influence the risk of cytogenetic relapse. MDR1-C3435T genotype might emerge as a potential biomarker to predict the risk of cytogenetic relapse in patients with CML.

  10. we found that the expression of P-gp (zeige ABCB4 Proteine) in primary MM cells derived from the bone marrow of MM patients was correlated to the hypoxic status of these cells, and that hypoxia induced P-gp (zeige ABCB4 Proteine) expression in MM cells in vitro. We further found that the hypoxia-induced resistance to bortezomib and carfilzomib in MM was reversed by pharmacological inhibition of P-gp (zeige ABCB4 Proteine) by tariquidar.

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. Data suggest that the overexpression of P-gp (zeige ABCB4 Proteine) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  2. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  3. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Proteine), multi-drug resistance protein, MDR1 (zeige ABCB4 Proteine)).Drugs with ER < 1 (zeige MIER1 Proteine) almost do not bind the main binding cavity (MBC (zeige CACNA1C Proteine)) of P-gp (zeige ABCB4 Proteine).

  4. conclusion, MDR1 (zeige ABCB4 Proteine) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Proteine)-II layer.

  5. Mdr1 (zeige ABCB4 Proteine) enforces T Cell homeostasis in the presence of intestinal bile acids.

  6. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  7. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  8. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  9. Chrysosplenetin inhibited P-gp (zeige ABCB4 Proteine) activity and reverse the up-regulated P-gp (zeige ABCB4 Proteine) and MDR1 (zeige ABCB4 Proteine) levels induced by artemisinin.

  10. Tamsulosin and tolterodine with P-gp (zeige ABCB4 Proteine) gene expression and activity in an enantiomer-specific way.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Überblick

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Genbezeichner und Symbole assoziert mit ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ABC20 Protein
  • ABCB1 Protein
  • CD243 Protein
  • CLCS Protein
  • GP170 Protein
  • mdr Protein
  • Mdr1 Protein
  • Mdr1a Protein
  • Mdr1b Protein
  • p-gp Protein
  • PGP1 Protein
  • Pgy-1 Protein
  • Pgy1 Protein
  • xemdr Protein

Bezeichner auf Proteinebene für ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
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