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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (281) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells.
Saikosaponin D could enhance the sensitivity of MCF-7/Adriamycin resistance cells towards ADR (zeige AKR1B1 ELISA Kits) by down-regulating MDR1 and P-gp (zeige ABCB4 ELISA Kits) expression.
Moreover, we found that genotypes rs34743033 3R/2R, rs16430 ins6/del6, rs1045642 CC or CT, and rs2032582 GG were beneficial predictors of clinical treatment outcome in AGC (zeige ACAN ELISA Kits) patients, suggesting some clinical implications in chemotherapy of a Chinese population.
Patients with both CYP3A5 (zeige CYP3A5 ELISA Kits)*3/*3 and MDR1 G2677A who underwent renal transplantation had higher blood TAC (zeige IL2RA ELISA Kits) concentrations than those without those genotypes. Japanese patients should be carefully monitored for consideration of lower TAC (zeige IL2RA ELISA Kits) doses, because 24% of Japanese patients have double mutations.
In this meta-analysis, we summarized the existing data on the associations of ABCB1 C3435T polymorphism with clopidogrel response, including biological and clinical outcomes in patients receiving clopidogrel antiplatelet treatment. The results show that the C3435T variant may increase the risk of bleeding in the Asian population, but no reliable findings were obtained about other outcomes.
Among two SNPs in CYP3A4 (zeige CYP3A4 ELISA Kits) and CYP3A5 (zeige CYP3A5 ELISA Kits) and 12 SNPs in ABCB1 gene, an association with ovarian cancer risk was observed for ABCB1 rs2157926 SNP only.
the allelic association of MDR1 C3435T and the association of the MDR1 3435 CC genotype with risk of drug-resistance were significant among European population
Promoter methylation was found to be an important mechanism in gene regulation of ABCB1 in parental cancer cell lines and their drug-resistant sublines.
This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3, ABCB1 and IL23R (zeige IL23R ELISA Kits)) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk.
Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase (zeige TXK ELISA Kits) inhibitors act as p-glycoprotein antagonists.
P-gp (zeige ABCB4 ELISA Kits), Bcrp and Mrp1 (zeige ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
Data suggest that the overexpression of P-gp (zeige ABCB4 ELISA Kits) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 ELISA Kits), multi-drug resistance protein, MDR1 (zeige ABCB4 ELISA Kits)).Drugs with ER < 1 almost do not bind the main binding cavity (MBC (zeige CACNA1C ELISA Kits)) of P-gp (zeige ABCB4 ELISA Kits).
conclusion, MDR1 (zeige ABCB4 ELISA Kits) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A ELISA Kits)-II layer.
Mdr1 (zeige ABCB4 ELISA Kits) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (zeige ABCB4 ELISA Kits) ATPase (zeige DNAH8 ELISA Kits) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 ELISA Kits) activity and reverse the up-regulated P-gp (zeige ABCB4 ELISA Kits) and MDR1 (zeige ABCB4 ELISA Kits) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 ELISA Kits) gene expression and activity in an enantiomer-specific way.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B