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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (257) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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MDR1 is not expressed on erythrocyte membrane.
The genetic polymorphisms of the multi-drug resistance-1 (MDR-1) and human cytochrome P450 (zeige CYP ELISA Kits) 3A (CYP3A4 (zeige CYP3A4 ELISA Kits) and CYP3A5 (zeige CYP3A5 ELISA Kits)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.
This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.
High MDR1 expression is associated with chemoresistance in ovarian cancer.
13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.
Haplotype analysis of ABCB1 conducted in patients with bullous pemphigoid (zeige DST ELISA Kits) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (zeige STS ELISA Kits). In addition, high MDR1 expression was significantly associated with local advances, as well as poor response to treatment.
P-gp (zeige ABCB4 ELISA Kits), Bcrp and Mrp1 (zeige ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
this study shows that MDR1 (zeige ABCB4 ELISA Kits) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (zeige ABCB4 ELISA Kits) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (zeige ABCB4 ELISA Kits)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (zeige ABCB4 ELISA Kits) can affect the pulmonary kinetics of a subset of P-gp (zeige ABCB4 ELISA Kits) substrates.
Data suggest that the overexpression of P-gp (zeige ABCB4 ELISA Kits) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 ELISA Kits), multi-drug resistance protein, MDR1 (zeige ABCB4 ELISA Kits)).Drugs with ER < 1 (zeige MIER1 ELISA Kits) almost do not bind the main binding cavity (MBC (zeige CACNA1C ELISA Kits)) of P-gp (zeige ABCB4 ELISA Kits).
conclusion, MDR1 (zeige ABCB4 ELISA Kits) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A ELISA Kits)-II layer.
Mdr1 (zeige ABCB4 ELISA Kits) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B