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The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
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these findings indicated that CH reversed Pglycoprotein-mediated MDR in Ovarian cancer A2780/Taxol cells by inhibiting the PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathway.
ABCB1 hypomethylation is associated with lower drug absorption, higher platelet reactivity, and an increased risk of ischemic events in our patients.
MDR1 gene variants and haplotypes were associated with ulcerative colitis in Serbian patients.
The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 transporter up-regulation.
ABCB1 genotype rs1045642 AA is associated with fentanyl administration in a cohort of children admitted to the pediatric intensive care unit, likely because of decreased expression and activity of p-glycoprotein
These results suggested that ABCB1 rs1045642 and UGT2B7 rs7439366 may affect oxcarbazepine pharmacokinetics and therapeutic efficacy in Han Chinese patients with epilepsy
results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility
MDR1 polymorphisms could affect the prognosis of multiple myeloma.
The MDR1/CYP3A4 (zeige CYP3A4 ELISA Kits)/OPRM1 (zeige OPRM1 ELISA Kits) gene polymorphisms influenced the fentanyl consumption and the physiological effects of intravenous analgesia in the Chinese women who received lower segment caesarean section surgeries.
Compared with palonosetron, ramosetron may be superior for reducing PONV severity, especially in patients with ABCB1 3435TT or 2677TT genotype
P-gp (zeige ABCB4 ELISA Kits), Bcrp and Mrp1 (zeige ABCC1 ELISA Kits) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.
This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.
Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance
ABCB1 is expressed in bovine oocytes and embryos.
Data suggest that the overexpression of P-gp (zeige ABCB4 ELISA Kits) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 ELISA Kits), multi-drug resistance protein, MDR1 (zeige ABCB4 ELISA Kits)).Drugs with ER < 1 almost do not bind the main binding cavity (MBC (zeige CACNA1C ELISA Kits)) of P-gp (zeige ABCB4 ELISA Kits).
conclusion, MDR1 (zeige ABCB4 ELISA Kits) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A ELISA Kits)-II layer.
Mdr1 (zeige ABCB4 ELISA Kits) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (zeige ABCB4 ELISA Kits) ATPase (zeige DNAH8 ELISA Kits) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 ELISA Kits) activity and reverse the up-regulated P-gp (zeige ABCB4 ELISA Kits) and MDR1 (zeige ABCB4 ELISA Kits) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 ELISA Kits) gene expression and activity in an enantiomer-specific way.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette, sub-family B (MDR/TAP), member 1
, ATP-binding cassette, subfamily B (MDR/TAP), member 1A
, multiple drug resistant 1a
, bovine P-glycoprotein
, ATP-binding cassette, subfamily B, member 1
, multidrug resistance p-glycoprotein
, multidrug resistance protein
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B