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The protein encoded by ARID4A is a ubiquitously expressed nuclear protein. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal ARID4A Primary Antibody für WB - ABIN2777742
Meehan, Samant, Hopper, Carrozza, Shevde, Workman, Eckert, Verderame, Welch: Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. in The Journal of biological chemistry 2004
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Consistently, our ITC assays also showed that DNA does not significantly enhance the histone binding ability of the chromo barrel domain of RBBP1.
The RBBP1 Tudor domain binds both double- and single-stranded DNA with an affinity of 10-100 muM; no apparent DNA sequence specificity was detected.
ARID4a (AT-rich interacting domain 4a, also known as RBP1) and CCL5 (zeige CCL5 Antikörper) (C-C motif ligand 5) are targets for miR (zeige MLXIP Antikörper)-302.
chromobarrel domain of RBBP1 is responsible for recognizing methylated histone tails in chromatin remodeling and epigenetic regulation
RBP1 and the mSin3 histone deacetylase (zeige HDAC1 Antikörper) complex bind to BRMS1 (zeige BRMS1 Antikörper) and repress transcription
there is an E2-dependent, ER isoform-specific transcriptional activation of the RBBP1 gene, which in part, is explained by the differential activity of ER AF1 (zeige EFNA5 Antikörper) and enhancer element binding
Alterations of BRMS1 (zeige BRMS1 Antikörper)-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.
ARID4A and ARID4B (zeige ARID4B Antikörper) function as transcriptional coactivators for AR and RB and play an integral part in the AR and RB regulatory pathways involved in the regulation of Sertoli cell function and male fertility.
RBP1 (zeige RBP1 Antikörper) and the mSin3 histone deacetylase (zeige HDAC1 Antikörper) complex bind to BRMS1 (zeige BRMS1 Antikörper) and repress transcription
The retinoblastoma binding protein 1 shows a marked genomic instability, which is coincidental with decreased DNA methylation, increased acetylation of histone H3 and decreased tri-methylation of histone H4 at lysine 20 (H4K20).
Arid4a-deficient mice initially display ineffective hematopoiesis, followed by transition to chronic myelomonocytic leukemia (CMML)-like myelodysplastic/myeloproliferative disorder, and then transformation to AML (zeige RUNX1 Antikörper).
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
AT-rich interactive domain-containing protein 4A
, AT rich interactive domain 4A (RBP1-like)
, retinoblastoma-binding protein 1
, at rich interactive domain 4a (rbp1 like)
, AT-rich interactive domain-containing protein 4A-like
, ARID domain-containing protein 4A
, retinoblastoma binding protein 1
, AT rich interactive domain 4A (Rbp1 like)