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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by A1CF. Zusätzlich bieten wir Ihnen A1CF Antikörper (49) und A1CF Kits (17) und viele weitere Produktgruppen zu diesem Protein an.
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Study reported that the deleted 8aa, EIYMNVPV, was just localized in the internal region of A1CF nuclear translocation signal. Also, A1CF (-8aa), but not its full-length counterpart, can promote proliferation of MDA-MB-231 cells accompanied with increased level of IL-6 (zeige IL6 Proteine) mRNA.
hnRNP K (zeige HNRNPK Proteine) and hnRNP L (zeige HNRNPL Proteine) may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation
The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 (zeige APOBEC1 Proteine) with ACF might be operational during enterocyte differentiation.
results suggested both AID and APOBEC-1 (zeige APOBEC1 Proteine) are equally likely to bind single-stranded DNA or RNA, which has implications for the identification of natural AID targets
ACF plays a crucial role, which is independent of apobec-1 (zeige APOBEC1 Proteine) expression, in cell survival, particularly during early embryonic development
Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 (zeige APOBEC1 Proteine) in RNA editing, or Argonaute 2 (AGO2 (zeige EIF2C2 Proteine)), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.
The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.
Data show that the importance of ACF for modulating ApoB (zeige APOB Proteine) was supported by the finding that RNAi knockdown of ACF reduced ApoB (zeige APOB Proteine) secretion.
ACF regulates liver regeneration following partial hepatectomy at least in part by controlling the stability of IL-6 (zeige IL6 Proteine) mRNA
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.
APOBEC-1 stimulating protein
, apo-B RNA editing protein
, apobec-1 complementation factor (ACF) (ASP)
, APOBEC1-stimulating protein
, apobec-1 complementation factor
, APOBEC1 complementation factort
, Apobec-1 complementation factor APOBEC-1 stimulating protein
, Apobec-1 complementation factor, APOBEC-1 stimulating protein
, APOBEC1 complementation factor