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AFF3 encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Dog (Canine) Polyclonal AFF3 Primary Antibody für WB - ABIN2778345
To, Faseruk, Gokgoz, Pinnaduwage, Done, Andrulis: LAF-4 is aberrantly expressed in human breast cancer. in International journal of cancer. Journal international du cancer 2005
AFF3 was overexpressed in tamoxifen-resistant tumors. AFF3 overexpression in breast cancer cells resulted in tamoxifen resistance, whereas RNA interference-mediated gene knockdown reversed this phenotype.
Data identified AFF3 as an interactive protein with beclin1 and suggest that AFF3 is probably a key regulator of Beclin-1.
Both the AFF3 and NTM triglyceride associations were replicated among Multi-ethnic Study of Atherosclerosis study participants (P = 1.00 x 10(-7) and 8.00 x 10(-5), respectively).
FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat.
Significant evidence for association of AFF3 rs10865035 with systgemic lupus erythmatgosus was detected.
overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles.
The LAF4 gene mapped on chromosome region 2q11.2-q12 has been identified as a fusion partner of the MLL gene in a case of infant acute lymphoblastic leukemia.
This gene is fused to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23).
LAF-4 may be a proto-oncogene that is transcriptionally activated in some cases of breast cancer.
array comparative genomic hybridization (CGH) analysis revealed a de novo interstitial microdeletion of 500 kb on chromosome 2q11.1 containing the LAF4/AFF3 (lymphoid-nuclear-protein-related AF4) gene
A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma.
AFF3 is a novel rheumatoid arthritis susceptibile gene.
AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron.
The neuronal migration deficit caused by loss of Laf4 can be partially rescued by Mdga2 over-expression, revealing an important functional relationship between these genes in a mouse model of intellectual disability.
Alternatively spliced forms encode several forms of putative protein with potentially different transactivation functions.
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
AF4/FMR2 family, member 3
, AF4/FMR2 family member 3
, MLLT2-related protein
, lymphoid nuclear protein 4
, lymphoid nuclear protein related to AF4
, protein LAF-4