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ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins.
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a portion of endogenous ARL4D and the GTP-binding-defective ARL4D mutant ARL4D(T35N) reside in the mitochondria
ARF4L 15-24 and ARF4L 69-77, possessed the ability to induce HLA-A2-restricted and tumor-reactive CTLs from peripheral blood mononuclear cells of patients with brain tumors
Study shows that three related Arf-like GTPases Arl4a (zeige ARL4A ELISA Kits), Arl4c, and Arl4d, are able to recruit ARNO (zeige CYTH2 ELISA Kits) and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
The results suggest that rapid reduction of Arl4D is required for adipogenesis to proceed.
analysis identified an epistatic interaction that plays a role in the buffering of HDL (zeige HSD11B1 ELISA Kits) levels in C57BL/6J mice, and we have identified Arl4d as a candidate gene that mediates this effect.
developmentally regulated ARL5 (zeige ARL5A ELISA Kits), with its distinctive nuclear/nucleolar localization and interaction with HP1alpha (zeige CBX5 ELISA Kits), may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development
Arl4D is a previously unknown regulator of neurite formation through cytohesin-2 (zeige CYTH2 ELISA Kits) and Arf6 (zeige ARF6 ELISA Kits), providing another example that the functional interaction of two different small GTPases controls an important cellular function.
ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS).
ADP-ribosylation factor-like 6
, ADP-ribosylation factor-like protein 4D
, ADP-ribosylation factor-like protein 4L
, ADP-ribosylation factor 4-like
, ADP-ribosylation factor-like 5
, ADP-ribosylation factor-like protein 5
, neuroprotective protein 2
, ADP-ribosylation factor-like 4D