ADP-Ribosylation Factor-Like 13B (ARL13B) ELISA Kits

ARL13B encodes a member of the ADP-ribosylation factor-like family. Zusätzlich bieten wir Ihnen ARL13B Antikörper (27) und ARL13B Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Ratte ARL13B ARL13B 304037  
ARL13B 200894 Q3SXY8
ARL13B 68146 Q640N2
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Weitere ELISA Kits für ARL13B Interaktionspartner

Zebrafish ADP-Ribosylation Factor-Like 13B (ARL13B) Interaktionspartner

  1. loss of Arl13b leads to slow photoreceptor degeneration, but can be exacerbated by the loss of vangl2 (zeige VANGL2 ELISA Kits). Importantly, the data show that Arl13b can genetically and physically interact with Vangl2 (zeige VANGL2 ELISA Kits) and this association is important for normal photoreceptor structure.

  2. Arl13b is an important effector of ciliary membrane biogenesis and ciliary length regulation.

  3. Cilia localization is essential for in vivo functions of the Joubert syndrome protein arl13b.

Human ADP-Ribosylation Factor-Like 13B (ARL13B) Interaktionspartner

  1. the results show that palmitoylation plays a unique and critical role in controlling the localization, stability, abundance, and thus function of ARL13b. Pharmacological manipulation of protein palmitoylation may be a strategy to alter cilia function.

  2. Our results show how Arl13b participates in Hedgehog (zeige SHH ELISA Kits) pathway activation in gastric cancer

  3. Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog (zeige SHH ELISA Kits) signaling in alkaptonuria (zeige HGD ELISA Kits).

  4. ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E (zeige PMPCA ELISA Kits).

  5. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).(

  6. Thus our data identify a novel ARL13B variant that causes JS and retinopathy and suggest an extension of the phenotypic spectrum of ARL13B mutations to obesity.

  7. We conclude that MKS/NPHP modules comprise a TZ barrier to ARL-13 diffusion, whereas IFT genes predominantly facilitate ARL-13 ciliary entry and/or retention via active transport mechanisms.

  8. X-ray crystallography of Arl13B demonstrates involvement of mutations R79Q and R200C in stabilizing intramolecular interactions.

  9. Arl13b acts as the all-rounder in cilia formation and signaling (Review).

  10. findings indicate that ARL13B, INPP5E (zeige PMPCA ELISA Kits), PDE6D (zeige PDE6D ELISA Kits), and CEP164 (zeige CEP164 ELISA Kits) form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS (zeige MKS1 ELISA Kits) proteins

Mouse (Murine) ADP-Ribosylation Factor-Like 13B (ARL13B) Interaktionspartner

  1. Arl13b dysfunction resulted in hennin cell stagnation due to poor growth factor signaling and impaired detection of extracellular electrical gradients.

  2. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).(

  3. To investigate whether Arl13b has a role in ciliogenesis in mammalian kidney and whether loss of function of Arl13b leads to cystic kidneys in mammals, we generated a mouse model with kidney-specific conditional knockout of Arl13b Deletion of Arl13b in the distal nephron at the perinatal stage led to a cilia biogenesis defect and rapid kidney cyst formation

  4. The authors show that the ciliary G-protein Arl13B, mutated in Joubert syndrome, is the guanine nucleotide exchange factor for Arl3, and its function is conserved in evolution

  5. A new role for Arl13b in actin cytoskeleton remodeling through the interaction with Myh9 (zeige MYH9 ELISA Kits).

  6. Early neuroepithelial deletion of ciliary Arl13b reversed the apical-basal polarity of radial progenitors & caused aberrant neuronal placement. Arl13b signaling in primary cilia is crucial for initial formation of a polarized radial glial scaffold.

  7. guidance cue receptors essential for interneuronal migration localize to interneuronal primary cilia, but their concentration and dynamics are altered in the absence of Arl13b

  8. By deleting Arl13b in mouse, we induced low-level constitutive GliA function at specific developmental stages and defined a crucial period prior to E10.5 when shifts in the level of GliA cause cells to change their fate

  9. Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 (zeige DAND5 ELISA Kits) is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.

  10. The role of Arl13b in ciliogenesis and it's interaction with Smo and Shh proteins.Arl13b regulates the ciliary entry of Smo.

ARL13B Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit ARL13B

  • ADP-ribosylation factor like GTPase 13B (Arl13b) Antikörper
  • ADP ribosylation factor like GTPase 13B (ARL13B) Antikörper
  • ADP ribosylation factor like GTPase 13B (arl13b) Antikörper
  • ADP-ribosylation factor-like 13b (arl13b) Antikörper
  • ADP-ribosylation factor-like 13B (Arl13b) Antikörper
  • A530097K21Rik Antikörper
  • A930014M17Rik Antikörper
  • Arl2l1 Antikörper
  • C530009C10Rik Antikörper
  • chunp6872 Antikörper
  • fc23g07 Antikörper
  • hnn Antikörper
  • JBTS8 Antikörper
  • MGC185757 Antikörper
  • wu:fc23g07 Antikörper
  • zgc:123149 Antikörper

Bezeichner auf Proteinebene für ARL13B

ADP-ribosylation factor-like protein 13B , ADP-ribosylation factor-like 2-like 1 , ADP-ribosylation factor-like 13B , ADP-ribosylation factor-like protein 13B-like , ADP-ribosylation factor-like protein 2-like 1 , ARL2-like protein 1 , protein scorpion , scorpion , un-named hi459 , unm hi459

GENE ID SPEZIES
304037 Rattus norvegicus
418431 Gallus gallus
460534 Pan troglodytes
487934 Canis lupus familiaris
512781 Bos taurus
694959 Macaca mulatta
100124913 Xenopus (Silurana) tropicalis
100413286 Callithrix jacchus
100456801 Pongo abelii
100467626 Ailuropoda melanoleuca
100600917 Nomascus leucogenys
286784 Danio rerio
200894 Homo sapiens
68146 Mus musculus
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