anti-3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Antikörper

The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Zusätzlich bieten wir Ihnen HMGCL Proteine (13) und HMGCL Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HMGCL 15356 P38060
HMGCL 3155 P35914
HMGCL 79238 P97519
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Top anti-HMGCL Antikörper auf antikoerper-online.de

Showing 10 out of 108 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-HMGCL Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Hund Kaninchen Unkonjugiert WB Host: Rabbit <br /> Target Name: Hmgcl <br /> Sample Tissue: Rat Thymus lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: H1299 10% SDS PAGE antibody diluted at 1:3000 IHC-P Image Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using HMGCL, antibody at 1:500 dilution. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert WB Western Blot: HMGCL Antibody [NBP1-58026] - Titration: 1.25ug/ml Positive Control: Human Liver. Western Blot: HMGCL Antibody [NBP1-58026] - analysis of HMGCL in LPS+ATP treated bone marrrow derived macrophages using anti-HMGCL antibody. Image from verified customer review. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$444.19
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: HMGCL Antibody [NBP1-83251] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17.Lane 2: Human cell line RT-4 Immunohistochemistry-Paraffin: HMGCL Antibody [NBP1-83251] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using HMGCL antibody. Immunohistochemistry of paraffin-embedded rat kidney using HMGCL antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, WB Western Blot: HMGCL Antibody [NBP1-32767] - (30 ug of whole cell lysate) A: H1299 10% SDS PAGE; antibody diluted at 1:3000 Immunocytochemistry/Immunofluorescence: HMGCL Antibody [NBP1-32767] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of HMG-CoA lyase / HMGCL Antibody (Center) in WiDr cell line lysates (35ug/lane). This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB HMGCL Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details

HMGCL Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-HMGCL Antikörper

  1. Human Monoclonal HMGCL Primary Antibody für ELISA, WB - ABIN561291 : Puisac, Arnedo, Casale, Ribate, Castiella, Ramos, Ribes, Pérez-Cerdá, Casals, Hegardt, Pié: Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria. in Journal of inherited metabolic disease 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal HMGCL Primary Antibody für WB - ABIN4319409 : Youm, Nguyen, Grant, Goldberg, Bodogai, Kim, DAgostino, Planavsky, Lupfer, Kanneganti, Kang, Horvath, Fahmy, Crawford, Biragyn, Alnemri, Dixit: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. in Nature medicine 2015 (PubMed)

  3. Human Polyclonal HMGCL Primary Antibody für IHC, IHC (p) - ABIN4319410 : Martinez-Outschoorn, Lin, Whitaker-Menezes, Howell, Lisanti, Sotgia: Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

Weitere Antikörper gegen HMGCL Interaktionspartner

Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Interaktionspartner

  1. Data suggest that HMGCS1 (HMG-CoA synthase (zeige HMGCS1 Antikörper) 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF (zeige BRAF Antikörper)(V600E)-dependent MEK1 (zeige MAP2K1 Antikörper) activation in BRAF (zeige BRAF Antikörper)(V600E)-positive melanoma and colon cancer cells; HMGCS1 (zeige HMGCS1 Antikörper) co-localizes with HMGCL (HMG-CoA lyase) and BRAF (zeige BRAF Antikörper)(V600E) in cytosol of melanoma and colon cancer cells. (BRAF (zeige BRAF Antikörper) = proto-oncogene (zeige RAB1A Antikörper) protein B (zeige LEPREL2 Antikörper)-raf (zeige SNRPE Antikörper))

  2. The genetic analysis revealed a novel homozygote deletion in exon 3 and 4 in HMGCL gene. HMG-CoA lyase deficiency should be thought in the patients with hypoketotic hypoglycemia, hyperammonemia, elevated liver function tests, noncompaction left ventricle and characteristic white matter changes and in the differential diagnosis of macrocephaly.

  3. this is the first study describing HMGCL deficiency caused by uniparental disomy.

  4. This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR (zeige HMGCR Antikörper) enzyme activity, tracing potential alterations in cholesterol biosynthesis.

  5. analysis of HMGCLL1 (zeige HMGCLL1 Antikörper) as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL

  6. An alternative transcript of HMGCS2 (zeige HMGCS2 Antikörper) carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  7. levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.

  8. Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.

  9. We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).

  10. A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG (zeige SSRP1 Antikörper)-CoA cleavage reaction chemistry that leads to acetyl-CoA (zeige LPCAT2 Antikörper) product formation.

HMGCL Antigen-Profil

Protein Überblick

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase S homeolog (hmgcl.S) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573) Antikörper
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl) Antikörper
  • Afu7g01720 Antikörper
  • AO090038000541 Antikörper
  • AW476067 Antikörper
  • HL Antikörper
  • zgc:56248 Antikörper

Bezeichner auf Proteinebene für HMGCL

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase , 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) , 3-hydroxy-3-methylglutarate-CoA lyase , HL , HMG-CoA lyase , hydroxymethylglutaryl-CoA lyase, mitochondrial , 3-hydroxy-3-methylglutaryl-CoA lyase , hydroxymethylglutaricaciduria , mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase , 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

GENE ID SPEZIES
432233 Xenopus laevis
456624 Pan troglodytes
710833 Macaca mulatta
3504221 Aspergillus fumigatus Af293
4589480 Neosartorya fischeri NRRL 181
4704707 Aspergillus clavatus NRRL 1
5997540 Aspergillus oryzae RIB40
7030025 Talaromyces marneffei ATCC 18224
8102925 Talaromyces stipitatus ATCC 10500
9522067 Arthroderma benhamiae CBS 112371
9580122 Trichophyton verrucosum HKI 0517
100174514 Pongo abelii
15356 Mus musculus
3155 Homo sapiens
317658 Bos taurus
79238 Rattus norvegicus
396316 Gallus gallus
394190 Danio rerio
478187 Canis lupus familiaris
Ausgewählte Anbieter für anti-HMGCL (HMGCL) Antikörper
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