anti-3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Antikörper

The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Zusätzlich bieten wir Ihnen HMGCL Proteine (16) und HMGCL Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HMGCL 15356 P38060
HMGCL 3155 P35914
HMGCL 79238 P97519
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Top anti-HMGCL Antikörper auf antikoerper-online.de

Showing 10 out of 110 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-HMGCL Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Hund Kaninchen Unkonjugiert WB Host: Rabbit  Target Name: Hmgcl  Sample Tissue: Rat Thymus lysates  Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-HMGCL Antibody Titration:  1.25ug/ml  Positive Control:  Human Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$249.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: H1299 10% SDS PAGE antibody diluted at 1:3000 IHC-P Image Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using HMGCL, antibody at 1:500 dilution. 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using HMGCL antibody. Immunohistochemistry of paraffin-embedded rat kidney using HMGCL antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 16 Days
$366.77
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: HMGCL Antibody [NBP1-83251] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17.Lane 2: Human cell line RT-4 Immunohistochemistry-Paraffin: HMGCL Antibody [NBP1-83251] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, WB Western Blot: HMGCL Antibody [NBP1-32767] - (30 ug of whole cell lysate) A: H1299 10% SDS PAGE; antibody diluted at 1:3000 Immunocytochemistry/Immunofluorescence: HMGCL Antibody [NBP1-32767] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$516.98
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of HMG-CoA lyase / HMGCL Antibody (Center) in WiDr cell line lysates (35ug/lane). This demonstrates the HMGCL antibody detected the HMGCL protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$551.83
Details

Am meisten referenzierte anti-HMGCL Antikörper

  1. Human Monoclonal HMGCL Primary Antibody für ELISA, WB - ABIN561291 : Puisac, Arnedo, Casale, Ribate, Castiella, Ramos, Ribes, Pérez-Cerdá, Casals, Hegardt, Pié: Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria. in Journal of inherited metabolic disease 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal HMGCL Primary Antibody für IHC, IHC (p) - ABIN4319410 : Martinez-Outschoorn, Lin, Whitaker-Menezes, Howell, Lisanti, Sotgia: Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

Weitere Antikörper gegen HMGCL Interaktionspartner

Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Interaktionspartner

  1. Data suggest that HMGCS1 (HMG-CoA synthase 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF(V600E)-dependent MEK1 activation in BRAF(V600E)-positive melanoma and colon cancer cells; HMGCS1 co-localizes with HMGCL (HMG-CoA lyase) and BRAF(V600E) in cytosol of melanoma and colon cancer cells. (BRAF = proto-oncogene protein B-raf)

  2. The genetic analysis revealed a novel homozygote deletion in exon 3 and 4 in HMGCL gene. HMG-CoA lyase deficiency should be thought in the patients with hypoketotic hypoglycemia, hyperammonemia, elevated liver function tests, noncompaction left ventricle and characteristic white matter changes and in the differential diagnosis of macrocephaly.

  3. this is the first study describing HMGCL deficiency caused by uniparental disomy.

  4. This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR enzyme activity, tracing potential alterations in cholesterol biosynthesis.

  5. in the 2 stop codon mutations c.109G>T and c.504_505delCT studied, the stop codon does not appear to be the cause of aberrant splicing; the mutation c.504_505delCT causes 2 mRNA transcripts with a stop codon that generate two simultaneous nonsense-mediated mRNA decay phenomena

  6. analysis of HMGCLL1 as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL

  7. An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  8. levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.

  9. Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.

  10. We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).

  11. The peroxisomal enzyme forms a covalently linked dimeric species upon crosslinking with dibromopropanone or o-phenylenedimaleimide . Cysteine-323 is required for intersubunit covalent crosslinking.

  12. A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG-CoA cleavage reaction chemistry that leads to acetyl-CoA product formation.

  13. Data describe the DNA mutational analysis of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.

  14. Exon 2 of HL skipping led to the loss of beta-sheet 1, and the skipping of exons 2 and 3 caused the disappearance of alpha helix 1 and beta-sheets 1 and 2

  15. Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase

  16. findings of common mutations in HMGCL have direct implications on rapid molecular diagnosis, prenatal and pre-implantation diagnosis and population based prevention programs directed towards 3HMG in Saudi Arabia.

  17. HMG-CoA located on the surface of the enzyme implicates Asn(311) and Lys(313) in substrate binding by establishing polar contacts with phosphate and ribose groups of adenosine, and Lys(48) by contacting the carboxyl group of the panthotenic acid moiety.

  18. The unique HMGCL gene mutations exist in Taiwanese 3-hydroxy-3-methylglutaryl CoA lyase deficiency deficiency patients.

  19. Finding that all identified missense mutations cause a >95% decrease in the enzyme activity, indicates that the disease appears only in very severe genotypes.

HMGCL Antigen-Profil

Protein Überblick

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase S homeolog (hmgcl.S) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573) Antikörper
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl) Antikörper
  • Afu7g01720 Antikörper
  • AO090038000541 Antikörper
  • AW476067 Antikörper
  • HL Antikörper
  • zgc:56248 Antikörper

Bezeichner auf Proteinebene für HMGCL

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase , 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) , 3-hydroxy-3-methylglutarate-CoA lyase , HL , HMG-CoA lyase , hydroxymethylglutaryl-CoA lyase, mitochondrial , 3-hydroxy-3-methylglutaryl-CoA lyase , hydroxymethylglutaricaciduria , mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase , 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

GENE ID SPEZIES
432233 Xenopus laevis
456624 Pan troglodytes
710833 Macaca mulatta
3504221 Aspergillus fumigatus Af293
4589480 Neosartorya fischeri NRRL 181
4704707 Aspergillus clavatus NRRL 1
5997540 Aspergillus oryzae RIB40
7030025 Talaromyces marneffei ATCC 18224
8102925 Talaromyces stipitatus ATCC 10500
9522067 Arthroderma benhamiae CBS 112371
9580122 Trichophyton verrucosum HKI 0517
100174514 Pongo abelii
15356 Mus musculus
3155 Homo sapiens
317658 Bos taurus
79238 Rattus norvegicus
396316 Gallus gallus
394190 Danio rerio
478187 Canis lupus familiaris
Ausgewählte Anbieter für anti-HMGCL (HMGCL) Antikörper
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