anti-SMAD4 (SMAD4) Antikörper

Bezeichnung:
anti-SMAD Family Member 4 Antikörper (SMAD4)
Auf www.antikoerper-online.de finden Sie aktuell 187 SMAD Family Member 4 (SMAD4) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD4 Kits (41) und SMAD4 Proteine (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 271 SMAD4 Produkte verfügbar.
Synonyme:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha

Meistgesuchte Reaktivitäten zu anti-SMAD4 (SMAD4) Antikörper

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anti-Human SMAD4 Antikörper:

anti-Mouse (Murine) SMAD4 Antikörper:

anti-Rat (Rattus) SMAD4 Antikörper:

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Am meisten referenzierte anti-SMAD4 Antikörper

  1. Human Polyclonal SMAD4 Primary Antibody für EIA, IHC (p) - ABIN358227 : Sekiya, Oda, Matsuura, Akiyama: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. in Biochemical and biophysical research communications 2004 (PubMed)
    Zeige alle 5 Referenzen für 358227

  2. Human Polyclonal SMAD4 Primary Antibody für IF, IHC (p) - ABIN272224 : Izumi, Nakamura, Tokumo, Mano: A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas. in JOP : Journal of the pancreas 2011 (PubMed)
    Zeige alle 5 Referenzen für 272224

  3. Human Polyclonal SMAD4 Primary Antibody für EIA, WB - ABIN401410 : Karlsson, Blank, Moody, Ehinger, Singbrant, Deng, Karlsson: Smad4 is critical for self-renewal of hematopoietic stem cells. in The Journal of experimental medicine 2007 (PubMed)
    Zeige alle 5 Referenzen für 401410

  4. Human Polyclonal SMAD4 Primary Antibody für ELISA, WB - ABIN1533870 : Hahn, Schutte, Hoque, Moskaluk, da Costa, Rozenblum, Weinstein, Fischer, Yeo, Hruban, Kern: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. in Science (New York, N.Y.) 1996 (PubMed)
    Zeige alle 2 Referenzen für 1533870

  5. Human Polyclonal SMAD4 Primary Antibody für DB, IF - ABIN389658 : Maru, Wu, Canada, Houlihan, Hamilton, Rashid: Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas. in Oncogene 2004 (PubMed)
    Zeige alle 2 Referenzen für 389658

  6. Cow (Bovine) Polyclonal SMAD4 Primary Antibody für WB - ABIN2779413 : Kantola, Keski-Oja, Koli: Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements. in Gene 2005 (PubMed)

  7. Mouse (Murine) Polyclonal SMAD4 Primary Antibody für ELISA, WB - ABIN184619 : Kim, Fan, Papadimitrakopoulou, Clayman, Hittelman, Hong, Lotan, Mao: DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. in Cancer research 1996 (PubMed)

  8. Human Monoclonal SMAD4 Primary Antibody für FACS - ABIN4895797 : Geng, Chen, Yuan, Peng, Maitra, Diao, Chen, Zhang, Hu, Qi, Pierce, Ling, Xiong, Li: The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis. in Nature communications 2016 (PubMed)

  9. Human Polyclonal SMAD4 Primary Antibody für IF, WB - ABIN392165 : Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013 (PubMed)

  10. Cow (Bovine) Polyclonal SMAD4 Primary Antibody für IHC, WB - ABIN2780673 : Aitchison, Veerakumarasivam, Vias, Kumar, Hamdy, Neal, Mills: Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. in The Prostate 2008 (PubMed)

Weitere Antikörper gegen SMAD4 Interaktionspartner

Human SMAD Family Member 4 (SMAD4) Interaktionspartner

  1. Genetic status of DPC4 contributes to the recurrence patterns in pancreatic ductal adenocarcinoma following pancreatectomy, and patients with an initially expressed DPC4 gene receive a greater benefit from intensive local control for locoregional recurrence

  2. NK cells from a SMAD4-deficient person affected by polyposis were hyper-responsive to TGF-beta

  3. SMAD4 mutation was commonly detected in pancreatic juice samples from patients with Pancreatic Ductal Adenocarcinoma, mutant SMAD4 concentrations could distinguish PDAC from Intraductal Papillary Mucinous neoplasm.

  4. Phosphorylation of SMAD4 is associated with Breast Cancer Metastasis.

  5. Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (zeige ENG Antikörper), two in BMPR1A (zeige BMPR1A Antikörper), one in PTEN (zeige PTEN Antikörper), and one in SMAD4. Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.

  6. Expression levels of Smad4 and miR (zeige MLXIP Antikörper)-34a in colorectal cancer patients had a significant inverse correlation and overexpressing miR (zeige MLXIP Antikörper)-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-beta (zeige TGFB1 Antikörper)/Smad4 pathway.

  7. MAD4 (zeige MXD4 Antikörper) has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase (zeige GSTa2 Antikörper) pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.

  8. Upon SMAD4 deletion, we detected high expression levels of FYN (zeige FYN Antikörper) in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  9. our data suggest that miR (zeige MLXIP Antikörper)-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1 (zeige CDH1 Antikörper), indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.

  10. SENP1 (zeige SENP1 Antikörper) deSUMOylated SMAD4 to promote EMT (zeige ITK Antikörper) via up-regulating E-cadherin (zeige CDH1 Antikörper) in prostate cancer cells. Therefore, SENP1 (zeige SENP1 Antikörper) is a potential target for treatment of advanced prostate cancer.

Mouse (Murine) SMAD Family Member 4 (SMAD4) Interaktionspartner

  1. In SMAD4 deficiency, NK cells unexpectedly acquired an innate lymphoid cell type 1-like gene signature and were unable to control tumor metastasis or viral infection. Mechanistically, SMAD4 restrained non-canonical TGF-beta (zeige TGFB1 Antikörper) signaling mediated by the cytokine receptor (zeige LEPR Antikörper) TGFbetaR1 in NK cells.

  2. The effect of Smad4 was at least partially mediated by the downstream effectors Syk (zeige SYK Antikörper) and ROCK2 (zeige ROCK2 Antikörper) transcription in megakaryocytes

  3. deletion of Smad4 in OBs (zeige LEP Antikörper) differentially modulates HSC (zeige FUT1 Antikörper) fate in a stage-dependent manner

  4. Data suggest that ovarian Bmp4 (zeige BMP4 Antikörper) levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 (zeige BMP4 Antikörper) expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK (zeige MAPK14 Antikörper) pathway regulates androgen and estrogen formation.

  5. The authors demonstrated that ubiquitin-specific protease (USP) 4 (zeige USP4 Antikörper) strongly induces activin (zeige Actbeta Antikörper)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  6. SMAD4 and STRA8 (zeige STRA8 Antikörper) are essential factors that regulate the female fate of germ cells.

  7. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (zeige BMP2 Antikörper) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (zeige ATF4 Antikörper).

  8. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (zeige VEGFC Antikörper) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  9. MZF1 (zeige ZSCAN1 Antikörper) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (zeige ZSCAN1 Antikörper)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  10. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

Pig (Porcine) SMAD Family Member 4 (SMAD4) Interaktionspartner

  1. Activated TGF-beta (zeige TGFB1 Antikörper) signaling rescued miR (zeige MYLIP Antikörper)-143-reduced FSHR (zeige FSHR Antikörper) and intracellular signaling molecules, and miR (zeige MYLIP Antikörper)-143-induced porcine granulosa cell apoptosis.

  2. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  3. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (zeige BRD2 Antikörper).

Cow (Bovine) SMAD Family Member 4 (SMAD4) Interaktionspartner

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (zeige FST Antikörper) are SMAD4 dependent.

  2. ALK5 (zeige TGFBR1 Antikörper) and Smad4 have roles in TGF-beta1 (zeige TGFB1 Antikörper)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) Interaktionspartner

  1. TGF-beta (zeige TGFB1 Antikörper) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4) Antikörper
  • Smad4 protein (smad4) Antikörper
  • mothers against decapentaplegic homolog 4 (LOC100342294) Antikörper
  • SMAD family member 4 (Smad4) Antikörper
  • SMAD family member 4, gene 1 (smad4.1) Antikörper
  • AW743858 Antikörper
  • D18Wsu70e Antikörper
  • dpc4 Antikörper
  • jip Antikörper
  • madh4 Antikörper
  • MYHRS Antikörper
  • smad4 Antikörper
  • Xsmad4 Antikörper
  • xsmad4a Antikörper
  • XSmad4alpha Antikörper

Bezeichner auf Proteinebene für SMAD4

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPEZIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
Ausgewählte Anbieter für anti-SMAD4 (SMAD4) Antikörper
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