anti-PKC alpha (PKCa) Antikörper

anti-Protein Kinase C, alpha Antikörper (PKCa)
Auf finden Sie aktuell 283 Protein Kinase C, alpha (PKCa) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PKC alpha Kits (46) und PKC alpha Proteine (21) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 362 PKC alpha Produkte verfügbar.
AAG6, AI875142, im:7139045, LOC100219195, PKC-alpha, Pkca, pkcalpha, PKRCA, PRKACA, si:dkey-8l19.1

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Am meisten referenzierte anti-PKC alpha Antikörper

  1. Cow (Bovine) Monoclonal PKC alpha Primary Antibody für ICC, FACS - ABIN153146 : Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999 (PubMed)
    Zeige alle 13 Referenzen für 153146

  2. Chicken Monoclonal PKC alpha Primary Antibody für IF, IP - ABIN967750 : Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008 (PubMed)
    Zeige alle 6 Referenzen für 967750

  3. Human Polyclonal PKC alpha Primary Antibody für EIA, IHC (p) - ABIN359058 : Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004 (PubMed)
    Zeige alle 5 Referenzen für 359058

  4. Human Polyclonal PKC alpha Primary Antibody für EIA, WB - ABIN453789 : Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992 (PubMed)
    Zeige alle 2 Referenzen für 453789

  5. Human Polyclonal PKC alpha Primary Antibody für IHC (p), WB - ABIN3043025 : Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015 (PubMed)
    Zeige alle 2 Referenzen für 3043025

  6. Human Polyclonal PKC alpha Primary Antibody für WB - ABIN3043549 : Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015 (PubMed)
    Zeige alle 2 Referenzen für 3043549

  7. Human Polyclonal PKC alpha Primary Antibody für IHC, ELISA - ABIN1531462 : Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015 (PubMed)

  8. Human Polyclonal PKC alpha Primary Antibody für FACS, IF - ABIN391001 : Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011 (PubMed)

Weitere Antikörper gegen PKC alpha Interaktionspartner

Xenopus laevis Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (zeige CDKN2A Antikörper) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Antikörper), leading to shortening of G1 and S phases

  2. Neural induction by Syn4 (zeige SNTG1 Antikörper) through the PKC (zeige PKC Antikörper) pathway requires inhibition of PKCdelta (zeige PKCd Antikörper) and activation of PKCalpha.

  3. The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC Antikörper) of the KCNE1 (zeige KCNE1 Antikörper) subunit underlies the GqPCR-mediated channel activation.

  4. Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC Antikörper) in Kv4.3 (zeige KCND3 Antikörper)

Rhesus Monkey Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.

Human Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. these results provide evidence for inherent deficits in the cystic fibrosis (zeige S100A8 Antikörper) macrophage oxidative burst caused by decreased phosphorylation of NADPH oxidase (zeige NOX1 Antikörper) cytosolic components that are augmented by Burkholderia

  2. The interplay between intracellular progesterone receptor (zeige PGR Antikörper) and PRKCA-PRKCD (zeige PKCd Antikörper) plays a key role in migration and invasion of human glioblastoma cells.

  3. PRKCA SNPs are associated with neuropathic pain post total joint replacement.

  4. These findings provide the first evidence linking PKC (zeige PRRT2 Antikörper) activation to suppression of Kv7 currents, membrane depolarization, and Ca(2 (zeige CA2 Antikörper)+) influx via L (zeige COX6A1 Antikörper)-type voltage-sensitive Ca(2 (zeige CA2 Antikörper)+) channels as a mechanism for histamine-induced bronchoconstriction.

  5. In polymorphism PRKCA rs9892651, HDL (zeige HSD11B1 Antikörper)-C levels were lower in carriers of CC and TC genotypes that were more frequent in current-wheezers Vs TT genotype (52.2 and 52.7 Vs 55.2 mg/dl, p-value = 0.042 and p-value for trend = 0.02).

  6. Ca(2+)-PKC-MARCKS-PIP2-PI3K-PIP3 system functions as an activation module in vitro

  7. phosphorylation of TIMAP (zeige PPP1R16B Antikörper) on Ser331 by PKC (zeige PRRT2 Antikörper) represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM (zeige ETV5 Antikörper) dephosphorylation

  8. PKCalpha-GSK3beta (zeige GSK3b Antikörper)-NF-kappaB (zeige NFKB1 Antikörper) signaling pathway involvement in TRAIL-induced apoptosis

  9. Curcumin inhibited phorbol ester-induced membrane translocation of protein kinase C-epsilon (PKCepsilon (zeige PRKCE Antikörper)) mutants, in which the epsilonC1 domain was replaced with alphaC1, but not the protein kinase C-alpha (PKCalpha) mutant in which alphaC1 was replaced with the epsilonC1 domain, suggesting that alphaC1 is a determinant for curcumin's inhibitory effect.

  10. a library of FRET sensors to monitor these transient complexes, specifically examining weak interactions between the catalytic domain of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper) and 14 substrate peptides.

Mouse (Murine) Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.

  2. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  3. We conclude that synaptotagmin-1 (zeige SYT1 Antikörper) phosphorylation is an essential step in PKC (zeige PKC Antikörper)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (zeige PKC Antikörper) substrates, Munc13-1 (zeige UNC13A Antikörper) and Munc18-1 (zeige STXBP1 Antikörper).

  4. These data indicate that LPA increases CCN2 (zeige CTGF Antikörper) expression through the activation of PKC (zeige PKC Antikörper) and PKA. Thus, the regulatory functions of the PKC (zeige PKC Antikörper) and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF Antikörper) expression

  5. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  6. We conclude that melatonin, via modulation of PKC (zeige PKC Antikörper) and Ca(2 (zeige CA2 Antikörper)+) signaling, could potentially stimulate the Nrf2 (zeige NFE2L2 Antikörper)-mediated antioxidant response in mouse pancreatic acinar cells.

  7. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (zeige TBXA2R Antikörper), possibly via increased pulmonary arterial TP receptor (zeige TBXA2R Antikörper) expression.

  8. at the functionally mature calyx of Held synapse the Ca(2 (zeige CA2 Antikörper)+)-dependent protein kinase C (zeige PKC Antikörper) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory

  9. PKC gene deletion is responsible for hair loss.

  10. The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.

Guinea Pig Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. PKC (zeige PKC Antikörper) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 Antikörper) and AMPA (zeige GRIA3 Antikörper)/kainate receptors.

  2. Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.

Cow (Bovine) Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

  2. Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T (zeige TNNT2 Antikörper).

  3. Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.

  4. calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Antikörper) Ser (zeige SIGLEC1 Antikörper)-328 is mediated by PKCalpha

  5. VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Antikörper).

  6. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.

  7. degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 Antikörper)

  8. Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.

  9. analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)

  10. By regulating VEGFR2 (zeige KDR Antikörper) expression and activation, PKC-epsilon (zeige PRKCE Antikörper) expression is critical for activation of Akt (zeige AKT1 Antikörper) and eNOS (zeige NOS3 Antikörper) by VEGF (zeige VEGFA Antikörper) and contributes to VEGF (zeige VEGFA Antikörper)-stimulated Erk (zeige MAPK1 Antikörper) activation, whereas PKC-alpha has opposite effects.

Rabbit Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Antikörper)+) transients and contractility.

  2. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.

  3. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.

Pig (Porcine) Protein Kinase C, alpha (PKCa) Interaktionspartner

  1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Antikörper) in intact smooth muscle tissues.

  2. Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Antikörper).

  3. The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.

  4. protein level of retinal PKC-alpha is increased with maturation

PKC alpha (PKCa) Antigen-Profil

Beschreibung des Gens

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Alternative names and synonyms associated with PKC alpha (PKCa)

  • protein kinase C, alpha (PRKCA) Antikörper
  • protein kinase C, alpha (prkca) Antikörper
  • protein kinase C, alpha (LOC100219195) Antikörper
  • protein kinase C, alpha (Prkca) Antikörper
  • AAG6 Antikörper
  • AI875142 Antikörper
  • im:7139045 Antikörper
  • LOC100219195 Antikörper
  • PKC-alpha Antikörper
  • Pkca Antikörper
  • pkcalpha Antikörper
  • PKRCA Antikörper
  • PRKACA Antikörper
  • si:dkey-8l19.1 Antikörper

Bezeichner auf Proteinebene für PKCa

pkc-like 2 , protein kinase C alpha type , protein kinase C, alpha , protein kinase C alpha type-like , PKC-A , aging-associated gene 6 , PKC-alpha , protein kinase c-alpha , protein kinase, C alpha , protein kinase C alpha

100063318 Equus caballus
447031 Xenopus laevis
497384 Danio rerio
780209 Xenopus (Silurana) tropicalis
100219195 Taeniopygia guttata
100391814 Callithrix jacchus
718412 Macaca mulatta
100591651 Nomascus leucogenys
5578 Homo sapiens
18750 Mus musculus
24680 Rattus norvegicus
100713627 Cavia porcellus
282001 Bos taurus
417430 Gallus gallus
490904 Canis lupus familiaris
100037720 Oryctolagus cuniculus
397184 Sus scrofa
101110074 Ovis aries
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