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anti-Human PKC alpha Antikörper:
anti-Mouse (Murine) PKC alpha Antikörper:
anti-Rat (Rattus) PKC alpha Antikörper:
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Chicken Monoclonal PKC alpha Primary Antibody für IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008
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Human Polyclonal PKC alpha Primary Antibody für EIA, IHC (p) - ABIN359058
Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004
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Human Polyclonal PKC alpha Primary Antibody für EIA, WB - ABIN453789
Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992
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Human Polyclonal PKC alpha Primary Antibody für FACS, IF - ABIN391001
Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011
Human Polyclonal PKC alpha Primary Antibody für IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (zeige CDKN2A Antikörper) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Antikörper), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 Antikörper) through the PKC (zeige PKC Antikörper) pathway requires inhibition of PKCdelta (zeige PKCd Antikörper) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC Antikörper) of the KCNE1 (zeige KCNE1 Antikörper) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC Antikörper) in Kv4.3 (zeige KCND3 Antikörper)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.
RNA sequencing identified a novel ATPase (zeige DNAH8 Antikörper), Ca2 (zeige CA2 Antikörper)+ transporting, plasma membrane 4(ATP2B4 (zeige ATP2B4 Antikörper))-protein kinase C-alpha (PRKCA) fusion transcript.
InB may exhibit growth-inhibitory activity through the activation of PKCalpha, followed by an increase in NFAT (zeige NFATC1 Antikörper) transactivation ability.
High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.
Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier (zeige SERTAD2 Antikörper) organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC (zeige PKC Antikörper))-independent manner.
this study identified PKC (zeige PRRT2 Antikörper) as the kinase that phosphorylates a specific site in the linker region of PACSIN2 (zeige PACSIN2 Antikörper).
results indicate that PKC (zeige PRRT2 Antikörper)-mediated cortactin (zeige CTTN Antikörper) phosphorylation might be implicated in the maintenance of growth cone
This study showed that SLC44A1 (zeige SLC44A1 Antikörper)-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value.
Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.
We conclude that melatonin, via modulation of PKC (zeige PKC Antikörper) and Ca(2 (zeige CA2 Antikörper)+) signaling, could potentially stimulate the Nrf2 (zeige NFE2L2 Antikörper)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (zeige TBXA2R Antikörper), possibly via increased pulmonary arterial TP receptor (zeige TBXA2R Antikörper) expression.
at the functionally mature calyx of Held synapse the Ca(2 (zeige CA2 Antikörper)+)-dependent protein kinase C (zeige PKC Antikörper) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (zeige AGT Antikörper)-dependent upregulation of renin (zeige REN Antikörper) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (zeige CREB1 Antikörper) pathway
role for PKCalpha in the regulation of ECM (zeige MMRN1 Antikörper) structure and deposition during skin wound healing.
A dynamic PKC (zeige PKC Antikörper) phosphorylation/de-phosphorylation cycle of Munc18-1 (zeige STXBP1 Antikörper) drives short-term enhancement of transmitter release during post-tetanic potentiation.
PKC-alpha and -delta have been shown to play crucial role in cardiac adaptation during physiological and pathological hypertrophy respectively thereby rendering compromised cardiac function to an otherwise efficient heart by conditional reversal of activation.
Data show increased expression of T-type Ca(2 (zeige CA2 Antikörper)+) current and association of protein kinase C alpha (PKCalpha) with caveolin-3 (Cav-3 (zeige CAV3 Antikörper))was disrupted in the hypertrophic ventricular myocyte.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T (zeige TNNT2 Antikörper).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Antikörper) Ser (zeige SIGLEC1 Antikörper)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Antikörper).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 Antikörper)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)
By regulating VEGFR2 (zeige KDR Antikörper) expression and activation, PKC-epsilon (zeige PRKCE Antikörper) expression is critical for activation of Akt (zeige AKT1 Antikörper) and eNOS (zeige NOS3 Antikörper) by VEGF (zeige VEGFA Antikörper) and contributes to VEGF (zeige VEGFA Antikörper)-stimulated Erk (zeige MAPK1 Antikörper) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Antikörper)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Antikörper) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Antikörper).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha