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anti-Human PKC alpha Antikörper:
anti-Mouse (Murine) PKC alpha Antikörper:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody für ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
Zeige alle 13 Referenzen für ABIN153146
Chicken Monoclonal PKC alpha Primary Antibody für IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008
Zeige alle 6 Referenzen für ABIN967750
Human Polyclonal PKC alpha Primary Antibody für EIA, IHC (p) - ABIN359058
Rabinovitz, Tsomo, Mercurio: Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. in Molecular and cellular biology 2004
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Human Polyclonal PKC alpha Primary Antibody für EIA, WB - ABIN453789
Rider, Vandamme, Lebeau, Vertommen, Vidal, Rousseau, Vandekerckhove, Hue: The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. in The Biochemical journal 1992
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Human Polyclonal PKC alpha Primary Antibody für IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Human Polyclonal PKC alpha Primary Antibody für FACS, IF - ABIN391001
Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor (zeige CDKN2A Antikörper) p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Antikörper), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 Antikörper) through the PKC (zeige PKC Antikörper) pathway requires inhibition of PKCdelta (zeige PKCd Antikörper) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (zeige PKC Antikörper) of the KCNE1 (zeige KCNE1 Antikörper) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (zeige PKC Antikörper) in Kv4.3 (zeige KCND3 Antikörper)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
After inhibition of the PKC/ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention.
authors found significant interactions among PRKCA, NOS3 (zeige NANOS3 Antikörper) and BDKRB2 (zeige BDKRB2 Antikörper) genotypes associated with enalapril responses.
Protein kinase C alpha (PKCalpha) is able to phosphorylate CK1delta at its C-terminally located residues S328, T329, and S370.
PKCalpha activity was effectively suppressed by the PKC inhibitor.
this study shows that the mTOR inhibitors suppression of invasion and migration of glioblastoma cells is mediated by reduction of PKC-alpha activity and downregulation of NFkappaB
PKCalpha controls HIF-1alpha (zeige HIF1A Antikörper) translation via AKT (zeige AKT1 Antikörper)-mTOR (zeige FRAP1 Antikörper) under hypoxic conditions.
Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C (zeige PKC Antikörper) isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 (zeige TRPC6 Antikörper) protein (TRPC6 (zeige TRPC6 Antikörper)) functions.
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
PKCalpha Attenuates Jagged-1 (zeige JAG1 Antikörper)-Mediated Notch (zeige NOTCH1 Antikörper) Signaling in ErbB-2 (zeige ERBB2 Antikörper)-Positive Breast Cancer to Reverse Trastuzumab Resistance
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (zeige SYT1 Antikörper) phosphorylation is an essential step in PKC (zeige PKC Antikörper)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (zeige PKC Antikörper) substrates, Munc13-1 (zeige UNC13A Antikörper) and Munc18-1 (zeige STXBP1 Antikörper).
These data indicate that LPA increases CCN2 (zeige CTGF Antikörper) expression through the activation of PKC (zeige PKC Antikörper) and PKA. Thus, the regulatory functions of the PKC (zeige PKC Antikörper) and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF Antikörper) expression
We conclude that melatonin, via modulation of PKC (zeige PKC Antikörper) and Ca(2 (zeige CA2 Antikörper)+) signaling, could potentially stimulate the Nrf2 (zeige NFE2L2 Antikörper)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2 (zeige TBXA2R Antikörper), possibly via increased pulmonary arterial TP receptor (zeige TBXA2R Antikörper) expression.
at the functionally mature calyx of Held synapse the Ca(2 (zeige CA2 Antikörper)+)-dependent protein kinase C (zeige PKC Antikörper) isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (zeige AGT Antikörper)-dependent upregulation of renin (zeige REN Antikörper) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (zeige CREB1 Antikörper) pathway
PKC (zeige PKC Antikörper) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 Antikörper) and AMPA (zeige GRIA3 Antikörper)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 Antikörper)+-sensitivity, structure and kinetics are brought about through PKC (zeige PKC Antikörper) phosphorylation of cardiac troponin T (zeige TNNT2 Antikörper).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Antikörper) expression by NF-kappaB (zeige NFKB1 Antikörper)-MT1-MMP (zeige MMP14 Antikörper)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Antikörper) Ser (zeige SIGLEC1 Antikörper)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Antikörper).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (zeige Akap6 Antikörper)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Antikörper) Calpha (zeige PRKACA Antikörper)
By regulating VEGFR2 (zeige KDR Antikörper) expression and activation, PKC-epsilon (zeige PRKCE Antikörper) expression is critical for activation of Akt (zeige AKT1 Antikörper) and eNOS (zeige NOS3 Antikörper) by VEGF (zeige VEGFA Antikörper) and contributes to VEGF (zeige VEGFA Antikörper)-stimulated Erk (zeige MAPK1 Antikörper) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Antikörper)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Antikörper) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Antikörper).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha