Hemochromatosis Type 2 (Juvenile) ELISA Kits (HFE2)
Auf www.antikoerper-online.de finden Sie aktuell 64 Hemochromatosis Type 2 (Juvenile) (HFE2) ELISA Kits von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HFE2 Antikörper (100) und HFE2 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 186 HFE2 Produkte verfügbar.
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DKFZp468F2322, DL-M, hemojuvelin, HFE2, HFE2A, HJV, JH, Rgmc

Am meisten referenzierte HFE2 ELISA Kits

  1. Human HFE2 ELISA Kit für Sandwich ELISA - ABIN415112 : Rumjon, Sarafidis, Brincat, Musto, Malyszko, Bansal, Macdougall: Serum hemojuvelin and hepcidin levels in chronic kidney disease. in American journal of nephrology 2012 (PubMed)
    Zeige alle 10 Referenzen für 415112

  2. Mouse (Murine) HFE2 ELISA Kit für Sandwich ELISA - ABIN415800 : Krijt, Frýdlová, Kukačková, Fujikura, Přikryl, Vokurka, Nečas: Effect of iron overload and iron deficiency on liver hemojuvelin protein. in PLoS ONE 2012 (PubMed)
    Zeige alle 2 Referenzen für 415800

Weitere ELISA Kits für HFE2 Interaktionspartner

Human Hemochromatosis Type 2 (Juvenile) (HFE2) Interaktionspartner

  1. A novel homozygous mutation in HJV gene identified in an Arab patient with juvenile hemochromatosis (zeige HFE ELISA Kits) and hepatocellular carcinoma.

  2. study shows that patients with CRA had high expression of BMP6 (zeige BMP6 ELISA Kits) and hepcidin (zeige HAMP ELISA Kits) and low expression of s-HJV. BMP6 (zeige BMP6 ELISA Kits) was found to be negatively correlated with s-HJV; both regulate hepcidin (zeige HAMP ELISA Kits) expression and play important roles in the development of anemia.

  3. HJV levels are low in NAFLD (zeige TSC2 ELISA Kits) and even lower in iron overloaded NAFLD (zeige TSC2 ELISA Kits).

  4. Data show that transmembrane serine protease (zeige F2 ELISA Kits) TMPRSS6 (zeige TMPRSS6 ELISA Kits) cleaves both the heterodimeric and the full-length mutant hemojuvelin (m-HJV).

  5. Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy.

  6. The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR (zeige UTS2R ELISA Kits) of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions.

  7. Case Reports: juvenile hemochromatosis (zeige HFE ELISA Kits) associated with simple heterozygosity for novel HJV mutations and unknown genetic factors.

  8. suggesting that the homozygous mutation p.C321X in HJV is causative in the patient with hemochromatosis (zeige HFE ELISA Kits)

  9. In dialysis patients, hemojuvelin levels are significantly increased but obesity does not have an additional impact.

  10. Membrane bound hemojuvelin (HJV) is associated with decreasing total kidney iron, secreting hepcidin (zeige HAMP ELISA Kits), and promoting the degradation of ferroportin (zeige SLC40A1 ELISA Kits) during acute kidney injury, whereas soluble HJV does the opposite.

Mouse (Murine) Hemochromatosis Type 2 (Juvenile) (HFE2) Interaktionspartner

  1. The data demonstrate that endothelial cells are the predominant source of BMP6 (zeige BMP6 ELISA Kits) in the liver and support a model in which endothelial cells BMP6 (zeige BMP6 ELISA Kits) has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin (zeige HAMP ELISA Kits) transcription and maintain systemic iron homeostasis.

  2. The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects.

  3. Results indicate that an efficient induction of hepcidin (zeige HAMP ELISA Kits) expression by hemojuvelin (HJV) requires its interaction with neogenin (zeige NEO1 ELISA Kits).

  4. Single Hjv(-)/(-) and double Hfe (zeige HFE ELISA Kits)(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe (zeige HFE ELISA Kits) and Hjv regulate hepcidin (zeige HAMP ELISA Kits) via the same pathway.

  5. Results show that HFE (zeige HFE ELISA Kits) may depend on HJV for hepcidin (zeige HAMP ELISA Kits) regulation. Residual hepcidin (zeige HAMP ELISA Kits) in the absence of HFE (zeige HFE ELISA Kits) suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin (zeige HAMP ELISA Kits).

  6. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice.

  7. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin (zeige HAMP ELISA Kits).

  8. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous.

  9. Loss of matriptase-2 (zeige TMPRSS6 ELISA Kits) increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.

  10. Use of proteomic analysis enables identification of four disulfide linkages in hemojuvelin/repulsive guidance molecule C. This molecule is a single-chain HJV/RGMc isoform.

HFE2 Antigen-Profil

Beschreibung des Gens

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Alternative names and synonyms associated with HFE2

  • hemochromatosis type 2 (juvenile) (HFE2) Elisa Kit
  • hemochromatosis type 2 (juvenile) (Hfe2) Elisa Kit
  • hemochromatosis type 2 (juvenile) (human homolog) (Hfe2) Elisa Kit
  • hemojuvelin (LOC100355707) Elisa Kit
  • 2310035L15Rik Elisa Kit
  • 5230400G09Rik Elisa Kit
  • AI414844 Elisa Kit
  • AI789733 Elisa Kit
  • DKFZp468F2322 Elisa Kit
  • DL-M Elisa Kit
  • hemojuvelin Elisa Kit
  • HFE2 Elisa Kit
  • HFE2A Elisa Kit
  • HJV Elisa Kit
  • JH Elisa Kit
  • Rgmc Elisa Kit

Bezeichner auf Proteinebene für HFE2

hemochromatosis type 2 (juvenile) , RGM domain family member C , haemojuvelin , hemochromatosis type 2 protein , hemojuvelin , repulsive guidance molecule c , hemochromatosis type 2 (juvenile) (human homolog) , hemochromatosis type 2 protein homolog , repulsive guidance molecule C

475830 Canis lupus familiaris
698805 Macaca mulatta
743630 Pan troglodytes
746490 Pan troglodytes
100174250 Pongo abelii
100594831 Nomascus leucogenys
148738 Homo sapiens
310681 Rattus norvegicus
100733082 Cavia porcellus
100155778 Sus scrofa
100335368 Bos taurus
101114997 Ovis aries
69585 Mus musculus
100355707 Oryctolagus cuniculus
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