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HFE2 ELISA Kit

HFE2 Reaktivität: Ratte AA 36-396 Colorimetric Sandwich ELISA
Produktnummer ABIN5510628
  • Target Alle HFE2 ELISA Kits anzeigen
    HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
    Bindungsspezifität
    AA 36-396
    Reaktivität
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Nachweismethode
    Colorimetric
    Methodentyp
    Sandwich ELISA
    Applikation
    ELISA
    Verwendungszweck
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Hemojuvelin/RGM-C
    Marke
    PicoKine™
    Analytische Methode
    Quantitative
    Spezifität
    Expression system for standard: NSO
    Immunogen sequence: Q36-D396
    Kreuzreaktivität (Details)
    There is no detectable cross-reactivity with other relevant proteins.
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  • Plattentyp
    Pre-coated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Haltbarkeit
    12 months
  • Target Alle HFE2 ELISA Kits anzeigen
    HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
    Andere Bezeichnung
    Hfe2 (HFE2 Produkte)
    Synonyme
    HFE2A ELISA Kit, HJV ELISA Kit, JH ELISA Kit, RGMC ELISA Kit, HFE2 ELISA Kit, DKFZp468F2322 ELISA Kit, 2310035L15Rik ELISA Kit, 5230400G09Rik ELISA Kit, AI414844 ELISA Kit, AI789733 ELISA Kit, DL-M ELISA Kit, Rgmc ELISA Kit, hemojuvelin ELISA Kit, RGMr ELISA Kit, hjv ELISA Kit, id:ibd3464 ELISA Kit, wu:fb38f10 ELISA Kit, zgc:136698 ELISA Kit, hemochromatosis type 2 (juvenile) ELISA Kit, hemochromatosis type 2 ELISA Kit, HFE2 ELISA Kit, Hfe2 ELISA Kit, hfe2 ELISA Kit
    Hintergrund

    Protein Function: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. .

    Background: Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of the repulsive guidance molecule family of proteins. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

    Synonyms: Hemojuvelin,Hemochromatosis type 2 protein homolog,RGM domain family member C,Hfe2,Rgmc,

    Full Gene Name: Hemojuvelin

    Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor . Also released in the extracellular space..
    UniProt
    Q8N7M5
    Pathways
    Transition Metal Ion Homeostasis
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