PCNA Proteine (PCNA)

Bezeichnung:
Proliferating Cell Nuclear Antigen Proteine (PCNA)
Auf www.antikoerper-online.de finden Sie aktuell 38 Proliferating Cell Nuclear Antigen (PCNA) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PCNA Antikörper (717) und PCNA Kits (53) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 825 PCNA Produkte verfügbar.
Synonyme:
53/13, AO090003000846, cb16, CG9193, Dmel\\CG9193, DmPCNA, dPCNA, fb36g03, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, Mus209, pcna, pcna-A, Pcna/cyclin, PCNA/mus209, PCNAR, wu:fa28e03, wu:fb36g03
alle Proteine anzeigen Gen GeneID UniProt
PCNA 5111 P12004
PCNA 18538 P17918
PCNA 25737 P04961

Weitere Synonyme anzeigen

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Am meisten referenzierte PCNA Proteine

  1. Human PCNA Protein expressed in Escherichia coli (E. coli) - ABIN667068 : Matsumoto, Moriuchi, Koji, Nakane: Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. in The EMBO journal 1987 (PubMed)
    Zeige alle 2 Referenzen für 667068

  2. Human PCNA Protein expressed in Baculovirus infected Insect Cells - ABIN2005057 : Ducoux, Urbach, Baldacci, Hübscher, Koundrioukoff, Christensen, Hughes: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. in The Journal of biological chemistry 2001 (PubMed)

Weitere Proteine zu PCNA Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. Results show that regulation of e2f1 (zeige E2F1 Proteine) and PCNA by DREF (zeige ZBED1 Proteine) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A

  3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.

  4. E2F (zeige E2F2 Proteine) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.

  5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (zeige POLD1 Proteine). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.

Tomato (Solanum lycopersicum) Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]

Human Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance.

  2. Multiple studies provide evidence that PCNA lies at the center of the faithful duplication of eukaryotic genomes and therefore genome integrity. [review]

  3. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.

  4. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  5. ECRG2 (zeige SPINK7 Proteine) in combination with cisplatin (DDP (zeige TIMM8A Proteine)) can inhibit viability and induce apoptosis in esophageal cancer DDP (zeige TIMM8A Proteine)-resistant cells, possibly via upregulation of p53 (zeige TP53 Proteine) expression and downregulation of PCNA expression.

  6. Reduced affinity of PCNA(S228I) for specific clients causes subtle cellular defects in undamaged cells which likely contribute to the etiology of PCNA-associated DNA repair disorder (PARD). Analysis of the binding between PCNA and PCNA-interacting proteins (PIPs (zeige GPRASP1 Proteine)) shows that the S228I change dramatically impairs the majority of these interactions, including that of Cdt1 (zeige CDT1 Proteine), DNMT1 (zeige DNMT1 Proteine), PolD3(p66 (zeige POLD3 Proteine)) and PolD4(p12 (zeige POLD4 Proteine)).

  7. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen) to the vicinity of its DNA target site is important; PCNA can be maintained at or near primer/template junctions during DNA synthesis by RPA (zeige RPA1 Proteine) (replication protein A (zeige GPR153 Proteine)) or SSB (single-stranded DNA-binding protein (zeige RPA1 Proteine)); here, the SSB used was from Escherichia coli.

  8. Studies demonstrated that POLH (zeige POLH Proteine) interaction with PCNA plays an indispensable role in the recruitment of pol-eta to UV-induced cyclobutane pyrimidine dimers site to carry out translesion synthesis (TLS (zeige FUS Proteine)), and the dissociation of pol-eta from PCNA after TLS (zeige FUS Proteine) is essential for maintaining high fidelity DNA replication.

  9. PCNA is a substrate of the HSV-1 deubiquitinase UL36USP, which has previously been shown to be involved mainly in virus uptake and maturation

  10. Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

Mouse (Murine) Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.

  2. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (zeige RAD18 Proteine).

  3. PCNA was mainly localized in decidual-stromal cells.

  4. Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (zeige ICAM1 Proteine) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.

  5. Data suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2).

  6. The aberrant DNA replication mediated by the PCNA-DNA pol-beta (zeige POLB Proteine) complex induces p53 (zeige TP53 Proteine)-dependent neuronal cell death

  7. Demonstrate that miR (zeige MLXIP Proteine)-376a regulates primordial follicle assembly by modulating the expression of Pcna.

  8. while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  9. Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.

  10. This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.

Zebrafish Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. The expression of telomerase activity and TERT (zeige TERT Proteine) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.

Pig (Porcine) Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish

Xenopus laevis Proliferating Cell Nuclear Antigen (PCNA) Interaktionspartner

  1. residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates

  2. CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.

  3. PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.

  4. Immunodepletion of Swift PAX-interacting protein 1 (zeige PAXIP1 Proteine) from Xenopus extracts prevented efficient PCNA ubiquitination

  5. PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.

PCNA Protein Überblick

Protein Überblick

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Alternative names and synonyms associated with PCNA

  • mutagen-sensitive 209 (mus209)
  • proliferating cell nuclear antigen (pcna)
  • proliferating cell nuclear antigen (pcnA)
  • proliferating cell nuclear antigen (ANI_1_512014)
  • proliferating cell nuclear antigen (AOR_1_1500154)
  • proliferating cell nuclear antigen (PCNA)
  • proliferating cell nuclear antigen (Pcna)
  • Proliferating cell nuclear antigen-like (MGC53867)
  • proliferating cell nuclear antigen-like (LOC100339381)
  • proliferating cell nuclear antigen1 (pcna1)
  • 53/13 Protein
  • AO090003000846 Protein
  • cb16 Protein
  • CG9193 Protein
  • Dmel\\CG9193 Protein
  • DmPCNA Protein
  • dPCNA Protein
  • fb36g03 Protein
  • l(2)02448 Protein
  • l(2)56F Protein
  • l(2)56Fa Protein
  • l(2)s1534 Protein
  • Mus209 Protein
  • pcna Protein
  • pcna-A Protein
  • Pcna/cyclin Protein
  • PCNA/mus209 Protein
  • PCNAR Protein
  • wu:fa28e03 Protein
  • wu:fb36g03 Protein

Bezeichner auf Proteinebene für PCNA

CG9193-PA , CG9193-PB , Proliferating-cell-nuclear-antigen , mus209-PA , mus209-PB , proliferating cell nuclear antigen , proliferating-cell nuclear antigen , DNA polymerase delta auxiliary protein , cyclin , etID36690.10 , fa28e03 , proliferating cell nuclear antigen subtype1 , proliferating cell nuclear antigen subtype2 , proliferating cell nuclear antigen subtype3 , CL1137_1 , CL1137_1(454) , CL1137_1_ov , proliferative cell nuclear antigen

GENE ID SPEZIES
37290 Drosophila melanogaster
544248 Solanum lycopersicum
857128 Guillardia theta
2761382 Methanococcus maripaludis S2
4978203 Aspergillus niger CBS 513.88
5788447 Bigelowiella natans
5991960 Aspergillus oryzae RIB40
10447350 Cryptomonas paramecium
5111 Homo sapiens
18538 Mus musculus
25737 Rattus norvegicus
30678 Danio rerio
477166 Canis lupus familiaris
515499 Bos taurus
373984 Gallus gallus
692192 Sus scrofa
100713865 Cavia porcellus
443155 Ovis aries
692356 Bombyx mori
394328 Xenopus laevis
100689335 Cricetulus griseus
398425 Xenopus laevis
100339381 Oryctolagus cuniculus
542425 Zea mays
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