anti-PTEN (PTEN) Antikörper

Bezeichnung:
anti-Phosphatase and Tensin Homolog Antikörper (PTEN)
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Synonyme:
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus PTEN PTEN 19211 O08586
Anti-Ratte PTEN PTEN 50557  
Anti-Human PTEN PTEN 5728 P60484

Weitere Synonyme anzeigen

Weitere Antikörper gegen PTEN Interaktionspartner

Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) Interaktionspartner

  1. these results demonstrate that miR (zeige MLXIP Antikörper)-26b might participate in regulating adipogenic differentiation in 3T3-L1 cells by inhibiting the PTEN expression, further highlighting the importance of miRNA in adipogenesis.

  2. Studies indicate complex PTEN-cooperating tumor suppressor networks in different cancer types, with potential clinical implications.

  3. Studies indicate that progesterone receptor (zeige PGR Antikörper) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (zeige CXCL9 Antikörper)-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (zeige MAPK1/3 Antikörper) and its target genes.

  4. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (zeige AKT1 Antikörper) pathway.

  5. Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 (zeige MUC1 Antikörper) and EMT (zeige ITK Antikörper) in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 (zeige MUC1 Antikörper) vaccines.

  6. novel role for PTEN during infection and identify regulation of the PI3K pathway, a mechanism previously shown to silence autoreactive B cells, as a key physiological target to control antibody responses.

  7. This study demonstrated Pten Regulates Retinal Amacrine Cell Number by Modulating Akt (zeige AKT1 Antikörper), Tgfbeta (zeige TGFB1 Antikörper), and Erk (zeige EPHB2 Antikörper) Signaling in mice.

  8. Tregs ameliorated ICH (zeige ACE Antikörper)-induced inflammatory injury by modulating microglia/macrophage polarization toward the M2 phenotype through the IL-10 (zeige IL10 Antikörper)/GSK3beta (zeige GSK3b Antikörper)/PTEN axis

  9. Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (zeige AKT1 Antikörper) pathway activation.

  10. this study shows this study shows that infection-induced miR (zeige MLXIP Antikörper)-21 promotes severe, steroid-insensitive allergic airway disease by reducing PTEN expression

Human Phosphatase and Tensin Homolog (PTEN) Interaktionspartner

  1. PTEN rs701848 and AKT1 (zeige AKT1 Antikörper) rs2494752 polymorphisms might be a candidate pharmacogenomic factor to assess the susceptibility of and response and prognosis prediction for interindividualized CE(A)F chemotherapy in breast cancer patients.

  2. Meta-analysis demonstrates that PTEN loss is of particular importance for predicting breast cancer aggressiveness and poor prognosis. PTEN is a potential drug target for the development of individualized treatment in breast cancer patients.

  3. PTENp1 was aberrantly expressed in oral squamous cell carcinoma. There was a positive correlation between the expression levels of PTENp1 and PTEN. Further, we showed that PTENp1 acted as a competing endogenous RNA that protects PTEN transcripts from being inhibited by miR (zeige MLXIP Antikörper)-21, and consequently inhibited proliferation and colony formation and triggered S-G2 (zeige STRN3 Antikörper)/M cell cycle arrest through the AKT (zeige AKT1 Antikörper) pathway.

  4. Results indicate that p110alpha (zeige PIK3CA Antikörper) primarily mediates PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling in HER2 (zeige ERBB2 Antikörper)+ PTEN deficient breast tumors whereas p110beta conditionally mediates HER2 (zeige ERBB2 Antikörper)/PI3K (zeige PIK3CA Antikörper) signaling in the absence of p110alpha (zeige PIK3CA Antikörper).

  5. Her-2 (zeige ERBB2 Antikörper)-positive metastatic breast cancers, PTEN positivity was significantly associated with progressive disease, but not with PFS or OS

  6. Findings indicate that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1 (zeige PDLIM7 Antikörper)), PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper), miR (zeige MLXIP Antikörper)-21 and PTEN constitute a positive feedback loop and have a key role in LMP1 (zeige PDLIM7 Antikörper)-induced cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC (zeige NPC1 Antikörper)).

  7. Coexpression of SALL4 (zeige SALL4 Antikörper) with HDAC1 (zeige HDAC1 Antikörper) and/or HDAC2 (zeige HDAC2 Antikörper) was associated with PTEN underexpression and a poor prognosis in hepatocellular carcinoma.

  8. PTEN promoter methylation is an independent predictor for impaired survival with malignant melanoma.

  9. Studies indicate that frequently altered genes in type I carcinomas are TP53, K-Ras, PTEN, and ss-catenin.

  10. Study provide evidence that PTEN deletion and TMPRSS2 (zeige TMPRSS2 Antikörper)-ERG (zeige ERG Antikörper) gene fusion were mutually exclusive in patients with prostate neoplasm. TMPRSS2 (zeige TMPRSS2 Antikörper)-ERG (zeige ERG Antikörper) gene fusion was rare compared to peripheral zone tumors and to PTEN inactivation in T1a (zeige PDPN Antikörper) transition zone tumors.

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) Interaktionspartner

  1. PTEN, FOXO3A (zeige FOXO3 Antikörper) and PKB (zeige AKT1 Antikörper) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) Interaktionspartner

  1. the miR-17-92 cluster is involved in granulosa cell proliferation and differentiation by coordinately targeting the PTEN and BMPR2 (zeige BMPR2 Antikörper) genes.

  2. miR (zeige MYLIP Antikörper)-26b participates in the inflammatory response of LPS (zeige IRF6 Antikörper)-stimulated bAMs by modulating the NF-kappaB (zeige NFKB1 Antikörper) pathway through targeting PTEN.

  3. Pten expression levels in the mammary glands of dairy cows, was investigated.

  4. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (zeige NOS3 Antikörper) activation in vascular endothelial cells.

  5. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  6. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) Interaktionspartner

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (zeige DVL2 Antikörper).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN Antigen-Profil

Beschreibung des Gens

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) Antikörper
  • phosphatase and tensin homolog (PTEN) Antikörper
  • phosphatase and tensin homolog (pten) Antikörper
  • 10q23del Antikörper
  • 2310035O07Rik Antikörper
  • A130070J02Rik Antikörper
  • AI463227 Antikörper
  • B430203M17Rik Antikörper
  • BZS Antikörper
  • CWS1 Antikörper
  • DEC Antikörper
  • GLM2 Antikörper
  • MHAM Antikörper
  • Mmac Antikörper
  • MMAC1 Antikörper
  • PTEN1 Antikörper
  • PTENP1 Antikörper
  • TEP1 Antikörper

Bezeichner auf Proteinebene für PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

GENE ID SPEZIES
19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis
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