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Human CSK Protein expressed in Wheat germ - ABIN1350517
Jo, Park, Lee, Ahn, Kim, Park, Choi: SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes. in PLoS ONE 2014
Data suggest that myristoylation of Src kinase is essential to facilitate Src (zeige SRC Proteine)-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase myristoylation, which is required for Src kinase association at cellular membrane, blocks dietary fat-accelerated tumorigenesis.
Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children.
H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation.
Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma.
deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis
Our results do not support association between PTPN22 (zeige PTPN22 Proteine)/CSK and Henoch-Schonlein purpura
Results identify CSK downregulation as a principal driver of SRC (zeige SRC Proteine) activation and castration resistance.
Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population.
CSK is the kinase responsible for C-terminal phosphorylation of SRC (zeige SRC Proteine), but not BRK (zeige PTK6 Proteine).
Data indicate that the potent c-Src (zeige SRC Proteine) inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma (zeige ARHGEF16 Proteine) xenograft model.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (zeige SRC Proteine), and these findings provide a novel therapeutic target for the treatment of hypertension
Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.
SHIP1 (zeige INPP5D Proteine) and Csk are part of the PSTPIP2 (zeige PSTPIP2 Proteine)-dependent inhibitory network that prevents the development of autoinflammatory disease.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.
Differentiation of embryonic stem cells is driven by c-Src (zeige SRC Proteine) is antagonized by c-Yes (zeige YES1 Proteine).
critical role in preventing TCR signaling
It was concluded that c-Src (zeige SRC Proteine) and NADPH oxidase (zeige NOX1 Proteine) components are necessary for redox-mediated production of TNF-alpha (zeige TNF Proteine) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
Dok-4 (zeige DOK4 Proteine) has a role as an anchoring molecule for the tyrosine kinase (zeige TYRO3 Proteine) c-Src (zeige SRC Proteine), and in turn as a regulator of TNF-alpha (zeige TNF Proteine)-mediated ROS (zeige ROS1 Proteine) production and NF-kappaB (zeige NFKB1 Proteine) activation
Src (zeige SRC Proteine) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (zeige NOS2 Proteine) in pulmonary artery endothelium.
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
, protein-tyrosine kinase CYL
, tyrosine-protein kinase CSK
, protein-tyrosine kinase MPK-2
, C-SRC kinase
, protein-tyrosine kinase (CSK)
, protein kinase
, src kinase