Lin-28 Homolog A (C. Elegans) Proteine (LIN28A)

Bezeichnung:
Lin-28 Homolog A (C. Elegans) Proteine (LIN28A)
Auf www.antikoerper-online.de finden Sie aktuell 19 Lin-28 Homolog A (C. Elegans) (LIN28A) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Lin-28 Homolog A (C. Elegans) Antikörper (169) und Lin-28 Homolog A (C. Elegans) Kits (24) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 221 Lin-28 Homolog A (C. Elegans) Produkte verfügbar.
Synonyme:
AL024421, CSDD1, ENSMUSG00000070700, Gm10299, Lin-28, lin-28A, LIN28, RGD1566408, sb:cb650, Tex17, ZCCHC1, zgc:55584
alle Proteine anzeigen Gen GeneID UniProt
LIN28A 298542  
LIN28A 79727 Q9H9Z2
LIN28A 83557 Q8K3Y3

Weitere Synonyme anzeigen

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Am meisten referenzierte Lin-28 Homolog A (C. Elegans) Proteine

  1. Human LIN28A Protein expressed in Escherichia coli (E. coli) - ABIN667750 : Heo, Joo, Kim, Ha, Yoon, Cho, Yeom, Han, Kim: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. in Cell 2009 (PubMed)
    Zeige alle 2 Referenzen für 667750

Weitere Proteine zu Lin-28 Homolog A (C. Elegans) Interaktionspartnern

Xenopus laevis Lin-28 Homolog A (C. Elegans) (LIN28A) Interaktionspartner

  1. the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone (zeige PTH Proteine) function.

Human Lin-28 Homolog A (C. Elegans) (LIN28A) Interaktionspartner

  1. It has been shown that the constitutive expression of Lin28a during neuronal differentiation in vitro positively and negatively affects numerous miRNAs.

  2. ur study demonstrated that disturbance of the let-7/LIN28 double-negative feedback loop is involved in the regulation of radio- and chemo-resistance, and that let-7 and LIN28 could be employed as predictive biomarkers of response to radiotherapy or chemotherapy in non-small-cell lung cancer patients.

  3. tight control by ESE3/EHF (zeige EHF Proteine) over the Lin28/let-7 axis is a critical barrier to malignant transformation.

  4. MSI2 (zeige MSI2 Proteine) might play a crucial role in sustaining stemness and chemoresistance of liver cancer stem cells in LIN28A-dependent manner in hepatocellular carcinoma.

  5. High LIN28A expression is associated with colorectal cancer.

  6. LIN28A and LIN28B (zeige LIN28B Proteine) play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  7. The molecular dynamics simulations suggest that a conserved structural feature of the loop regions of pre-let-7 miRNAs is more important for LIN28 recognition than sequence conservation among members of the let-7 family or the presence of the GGAG motif in the 3' region.

  8. Lin28A is up-regulated in 73.3 % of colon cancer patients. Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting apoptosis in a let-7 independent manner, associated with decreasing the expression of DNA damage repair protein H2AX.

  9. Upregulation of let-7a carries the potential to reverse CCL18 (zeige CCL18 Proteine) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 expression.

  10. Data suggest that the Lin28/let-7 (lin-28 homolog protein/mirnlet7 microRNA) molecular switch plays roles in regulation of cell growth signaling pathways and in regulation of expression of metabolic enzymes. [REVIEW]

Cow (Bovine) Lin-28 Homolog A (C. Elegans) (LIN28A) Interaktionspartner

  1. Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.

Mouse (Murine) Lin-28 Homolog A (C. Elegans) (LIN28A) Interaktionspartner

  1. During ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.-

  2. LIN28A and LIN28B (zeige LIN28B Proteine) play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.

  3. MAPK/ERK (zeige MAPK1 Proteine) directly impacts LIN28, defining an axis that connects signalling, post-transcriptional gene control, and cell fate regulation.

  4. Sirt1 (zeige SIRT1 Proteine) knockdown abolished the protective effects of Lin28a against cardiac remodeling and dysfunction after MI, and Lin28a failed to increase the numbers of GFP-LC3 (zeige MAP1LC3A Proteine)-positive punctae and decrease aggresome and p62 (zeige GTF2H1 Proteine) accumulation in Sirt1 (zeige SIRT1 Proteine)-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury.

  5. data point toward a complex system of regulation by Lin28a, Lin28b (zeige LIN28B Proteine), and let-7, in which Lin28b (zeige LIN28B Proteine) and let-7 can impact both puberty and growth in a sex-specific manner

  6. Lin28A binds active promoters and recruits Tet1 (zeige TET1 Proteine) to regulate gene expression via epigenetic DNA modifications.

  7. Lin28a protects against DCM through PKA/ROCK2 (zeige ROCK2 Proteine) dependent pathway.

  8. Lin28B (zeige LIN28B Proteine) upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development

  9. Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin (zeige INS Proteine)-PI3K-mTOR (zeige FRAP1 Proteine) pathway.

  10. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions

Zebrafish Lin-28 Homolog A (C. Elegans) (LIN28A) Interaktionspartner

  1. The knockdown of Lin-28a or Lin-28b (zeige LIN28B Proteine) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.

  2. The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.

Lin-28 Homolog A (C. Elegans) (LIN28A) Protein Überblick

Protein Überblick

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

Alternative names and synonyms associated with Lin-28 Homolog A (C. Elegans) (LIN28A)

  • lin-28 homolog C (C. elegans) (Lin28c)
  • lin-28 homolog A (lin28a)
  • lin-28 homolog (C. elegans) (lin28)
  • RNA-binding protein LIN-28 (lin28)
  • lin-28 homolog A (C. elegans) (LIN28A)
  • lin-28 homolog A (C. elegans) (Lin28a)
  • lin-28 homolog A (C. elegans) (lin28a)
  • AL024421 Protein
  • CSDD1 Protein
  • ENSMUSG00000070700 Protein
  • Gm10299 Protein
  • Lin-28 Protein
  • lin-28A Protein
  • LIN28 Protein
  • RGD1566408 Protein
  • sb:cb650 Protein
  • Tex17 Protein
  • ZCCHC1 Protein
  • zgc:55584 Protein

Bezeichner auf Proteinebene für LIN28A

lin-28A , protein lin-28 homolog A , lin-28 homolog , RNA-binding protein LIN-28 , lin-28 homolog A (C. elegans) , lin-28-like , RNA-binding protein LIN-28A , zinc finger CCHC domain-containing protein 1 , zinc finger, CCHC domain containing 1 , testis expressed gene 17 , testis-expressed protein 17 , Lin-28.1 , RNA-binding protein lin-28

GENE ID SPEZIES
298542 Rattus norvegicus
548523 Xenopus (Silurana) tropicalis
549020 Xenopus (Silurana) tropicalis
100012320 Monodelphis domestica
100071098 Equus caballus
100302344 Ovis aries
100379627 Felis catus
387262 Xenopus laevis
79727 Homo sapiens
612162 Canis lupus familiaris
100142662 Sus scrofa
614997 Bos taurus
83557 Mus musculus
500562 Rattus norvegicus
456661 Pan troglodytes
428206 Gallus gallus
394066 Danio rerio
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