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The Tim-3/Gal-9 (zeige LGALS9 Proteine) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Results indicate that T cell Ig and mucin domain 3 protein (TIM-3) polymorphisms (-1516G/T, -574G/T, and +4259T/G) were associated with the increased risk of cancer in Chinese Han population.
In cultured MART1 (zeige MLANA Proteine)-specific CD8 (zeige CD8A Proteine) T cells stimulated with peptide-loaded artificial antigen-presenting cells, anti-TIM-3 antibody treatment promotes generation of effector T cells, with acquisition of an activated phenotype, increased cytokine production, enhanced proliferation, and a transcription program associated with T cell differentiation. Anti-TIM-3 drives CD8 (zeige CD8A Proteine) T cell differentiation through activation of mTORC1.
Our results show that Tim-3 is a critical negative regulator of NLRP3 (zeige NLRP3 Proteine) inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
soluble Tim-3 might play inhibitory roles in impaired Tim-3-mediated clearance of apoptotic cells in systemic lupus erythematosus.
We found a novel mechanism through which Tim-3 could suppress antitumor immunity by utilizing the suppression of CD4 (zeige CD4 Proteine)(+) follicular helper cells (Tfh) function and provide new insight in the regulation of Tfh cells in breast cancer patients
Tim3/Gal-9 (zeige LGALS9 Proteine) alleviates the inflammation of TAO patients via suppressing Akt (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway.
this study shows that severe aplastic anemia untreated patients have lower TIM-3 expression on NK cells and CD56dim NK subsets compared with normal controls, and are correlated with the severity of pancytopenia of SAA (zeige SAA1 Proteine)
We conclude that Tim-3 is a biomarker of dysfunctional plasmacytoid dendritic cells
The present study defines the minimal TIM-3 promoter region and demonstrates its interaction with c-Jun (zeige JUN Proteine) during TIM-3 transcription in CD4 (zeige CD4 Proteine)(+) T cells.
Our findings establish intratumoral Tim-3(+)PD1 (zeige PDCD1 Proteine)(+)CD8 (zeige CD8A Proteine)(+) T cells as critical mediators of an aggressive phenotype in RCC (zeige XRCC1 Proteine).
CB2R (zeige CNR2 Proteine) may have a crucial neuroprotective role following HI insult through the modulation of the inflammatory-related HIF-1alpha (zeige HIF1A Proteine)/TIM-3 signalling pathway in microglia
demonstrated that both IL-10 (zeige IL10 Proteine) and TGF-beta (zeige TGFB1 Proteine) upregulated TIM-3 surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src (zeige SRC Proteine) and Bruton's tyrosine kinase (zeige BTK Proteine)
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (zeige HDAC3 Proteine)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (zeige HDAC3 Proteine)-induced chronic allergic airway inflammation.
Authors found that a CD8 (zeige CD8A Proteine)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (zeige TIMD4 Proteine) binds TIM3 on the surface of polarized Th1 (zeige HAND1 Proteine) cells to induce Th1 (zeige HAND1 Proteine) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (zeige LGALS9 Proteine)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (zeige LYN Proteine) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (zeige FCER1A Proteine) ligation.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog