HVEM Protein (Fc Tag)

Produktnummer ABIN935461

Recombinant HVEM-Protein exprimiert in Hi-5 Cells.

Kurzübersicht für HVEM Protein (Fc Tag) (ABIN935461)

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Hi-5 Cells

Reinheit: > 98 % pure

Produktdetails

Aufreinigungstag / Konjugat: Dieses HVEM Protein ist gelabelt mit Fc Tag.

Sequenz: LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK. Conjugated to Fc.

Produktmerkmale: Purified recombinant HVEM Fc protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to neutralize 0.25 ng/mL of hTNFbeta induced cytotoxicity on Mouse L929 cells. The expected ED50 for this effect is 1.3-1.9 µg/mL of HVEM-Fc.

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Kommentare:

Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Antigendetails

Target: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Andere Bezeichnung: HVEM

Sub Type: Fusionprotein

Substanzklasse: Viral Protein

Hintergrund: HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a "receptor decoy" resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
Alternative Names: HVEM protein, TR2 protein, TNFSFR14 protein, ATAR protein

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints