NOTCH3 Proteine (NOTCH3)

Notch 3 Proteine (NOTCH3)
Auf finden Sie aktuell 10 Notch 3 (NOTCH3) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NOTCH3 Antikörper (206) und NOTCH3 Kits (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 229 NOTCH3 Produkte verfügbar.
AW229011, CADASIL, CASIL, fa14b08, hpbk, IMF2, N3, notch5, wu:fa14b08
alle Proteine anzeigen Gen GeneID UniProt
NOTCH3 4854 Q9UM47
NOTCH3 18131 Q61982
Ratte NOTCH3 NOTCH3 56761 Q9R172

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Weitere Proteine zu NOTCH3 Interaktionspartnern

Human Notch 3 (NOTCH3) Interaktionspartner

  1. Low Notch3 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.

  2. High NOTCH3 expression is associated with basal breast cancer.

  3. in in silico gene expression analysis of human T-ALL samples we observed a significant correlation between Pin1 (zeige PIN1 Proteine) and Notch3 expression levels, which may further suggest a key role of the newly identified Notch3-Pin1 (zeige PIN1 Proteine) axis in T-cell Acute Lymphoblastic Leukemia (T-ALL) aggressiveness and progression. Thus, combined suppression of Pin1 (zeige PIN1 Proteine) and Notch3 proteins may be exploited as an additional target therapy for T-ALL

  4. Data indicate that mRNA high expression level of Notch1 (zeige NOTCH1 Proteine) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)), HR, and mRNA high expression levels of Notch2 (zeige NOTCH2 Proteine) and Notch3 were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 (zeige NOTCH4 Proteine) was not found to be associated with to OS for all NSCLC.

  5. MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3 pathway.

  6. Intermittent compressive stress regulates Notch (zeige NOTCH1 Proteine) receptor and target gene expression via the TGF-beta (zeige TGFB1 Proteine) signaling pathway. Notch (zeige NOTCH1 Proteine) signaling participates in TGF-beta (zeige TGFB1 Proteine)-induced sclerostin (zeige SOST Proteine) expression in periodontal ligament cells.

  7. Specific Notch3 and Jag1 (zeige JAG1 Proteine) subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 (zeige JAG1 Proteine) targeting in triple-negative breast cancer patients

  8. there is a cross-talk between Jagged1 (zeige JAG1 Proteine)/Notch3 and VEGF (zeige VEGFA Proteine) in TNBC angiogenesis. Jagged1 (zeige JAG1 Proteine)/Notch3 is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.

  9. Mutations in NOTCH3 gene is associated with T-cell acute lymphoblastic leukemia.

  10. Loss of Notch3 expression may be fundamental to the process of dedifferentiation that accompanies thyroid oncogenesis. Conversely, activation of Notch3 in thyroid cancer exerts an antiproliferative effect and restores elements of a differentiated phenotype

Mouse (Murine) Notch 3 (NOTCH3) Interaktionspartner

  1. this study shows that Notch (zeige NOTCH1 Proteine) signaling regulates basophils biological function, at least partially via the modulation of MAPK (zeige MAPK1 Proteine)

  2. Knock-in mice with the R169C mutation (Notch3(R170C/R170C)) exhibited similar reductions in arterial lumen, and both TgNotch3(R169C) and Notch3(R170C/R170C) mice showed increased cerebral artery expression of Notch3 target genes.

  3. Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1 (zeige TGFB1 Proteine)/Smad3 (zeige SMAD3 Proteine) signaling.

  4. Data indicate that Notch (zeige NOTCH1 Proteine) receptors Notch1 (zeige NOTCH1 Proteine) and Notch3 deficiency compromises pericyte function and contributes to vascular pathologies.

  5. In this study, authors use a smooth muscle-specific (zeige EIF3K Proteine) deletion of Notch2 (zeige NOTCH2 Proteine) together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2 (zeige NOTCH2 Proteine)/3 alleles in vascular smooth muscle cells

  6. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.

  7. Mutant Notch3 accumulates in pericytes and causes progressive pericyte loss and BBB leakage in the cerebral cortex in CADASIL mouse model.

  8. Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4 (zeige NOTCH4 Proteine)-/- compared with wild-type and Notch3-/- mice.

  9. The mechanism of Oncostatin M (zeige OSM Proteine) on cardiac ischemia/reperfusion injury is partly mediated by the Notch3/Akt (zeige AKT1 Proteine) pathway.

  10. miR (zeige MLXIP Proteine)-7a regulates the differentiation of Muller glia through the suppression of Notch3 expression.

Zebrafish Notch 3 (NOTCH3) Interaktionspartner

  1. The Notch3 receptor is required earlier within the developing somite to regulate hematopoietic stem cell (HSC (zeige FUT1 Proteine)) emergence in a non-cell-autonomous manner.

  2. 90 % of proliferating radial glia express notch1a, notch1b and notch3. In contrast, the proliferating non-glial populations of the dorsal telencephalon and hypothalamus rarely express notch3 and about half express notch1a/1b.

  3. Notch3 regulates oligodendrocyte precursor cells development and mbp (zeige MBP Proteine) gene expression in larvae, and maintains vascular integrity in adults.

  4. new role for Notch (zeige NOTCH1 Proteine) signaling in brain vascular development whereby Notch3 signaling promotes expansion of the brain pericyte population

  5. Notch3 activity gates neural stem cell activation in the adult pallium.

  6. Cellular correlates of Notch (zeige NOTCH1 Proteine)-delta gene expression in the regenerating zebrafish retina.

  7. knockdown of notch3 function in notch1a mutants leads to the loss of rhombomere boundary cells and causes neuronal hyperplasia

NOTCH3 Protein Überblick

Protein Überblick

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Alternative names and synonyms associated with NOTCH3

  • notch 3 (NOTCH3)
  • notch 3 (Notch3)
  • notch homolog 3 (notch3)
  • AW229011 Protein
  • CADASIL Protein
  • CASIL Protein
  • fa14b08 Protein
  • hpbk Protein
  • IMF2 Protein
  • N3 Protein
  • notch5 Protein
  • wu:fa14b08 Protein

Bezeichner auf Proteinebene für Notch 3 Proteine (NOTCH3)

Notch homolog 3 , neurogenic locus notch homolog protein 3 , Notch gene homolog 3

4854 Homo sapiens
18131 Mus musculus
56761 Rattus norvegicus
58066 Danio rerio
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