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anti-Human MAP3K12 Antikörper:
anti-Rat (Rattus) MAP3K12 Antikörper:
anti-Mouse (Murine) MAP3K12 Antikörper:
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Human Polyclonal MAP3K12 Primary Antibody für ELISA, WB - ABIN4332642
Douziech, Laberge, Grondin, Daigle, Blouin: Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999
Show all 6 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody für IHC (p), WB - ABIN391319
Itoh, Wang, Ito, Reddy, Itoh: SP3 acts as a positive regulator on the core promoter of human ZPK gene. in Biochemical and biophysical research communications 2003
Show all 7 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody für IHC, IHC (p) - ABIN4332643
Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh: ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Human Polyclonal MAP3K12 Primary Antibody für IHC, IHC (fro) - ABIN4332644
Welsbie, Mitchell, Jaskula-Ranga, Sluch, Yang, Kim, Buehler, Patel, Martin, Zhang, Ge, Duan, Fuller, Kim, Hamed, Chamling, Lei, Fraser, Ronai, Berlinicke, Zack: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. in Neuron 2017
SASH1 (zeige SASH1 Antikörper) acts through NOTCH1 (zeige NOTCH1 Antikörper) and its inhibitor DLK1 (zeige DLK1 Antikörper) in a three-dimensional model of lumenogenesis involving CEACAM1 (zeige CEACAM1 Antikörper).
The data presented in this work suggest that a fine regulation of NOTCH (zeige NOTCH1 Antikörper) signaling BY DLK1 (zeige DLK1 Antikörper) plays an important role in the control of breast cancer cell proliferation and invasion.
results demonstrate that miR (zeige MLXIP Antikörper)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1 (zeige DLK1 Antikörper)
A complex defect of DLK1 (zeige DLK1 Antikörper) ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1 (zeige DLK1 Antikörper), including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1 (zeige DLK1 Antikörper).
Loss of DLK1 (zeige DLK1 Antikörper) expression is associated with fetal growth retardation complications of pregnancy.
LZK (zeige MAP3K13 Antikörper) cooperates with DLK (zeige DAPK3 Antikörper) to promote retinal ganglion cell death in response to axon injury.
In neonatal skin, DLK1 (zeige DLK1 Antikörper) exhibited a high degree of monoallelic expression from the paternal allele.
The study evaluated the roles of extracellular soluble DLK1 (zeige DLK1 Antikörper), comprising six EGF (zeige EGF Antikörper)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (zeige MIA Antikörper) PaCa-2 cells in vitro and in vivo. Soluble DLK1 (zeige DLK1 Antikörper) exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.
Treatment of mice with recombinant human DLK1 (zeige DLK1 Antikörper) during pregnancy has significant effects on AT of the offspring. This can be associated with counter-regulatory changes in the Notch1 (zeige NOTCH1 Antikörper) signaling cascade.
NOTCH1 (zeige NOTCH1 Antikörper) ligand Delta-like 1 (zeige DLL1 Antikörper) homolog (DLK1 (zeige DLK1 Antikörper)) self interacts
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
the prevention of the nuclear localization of DLK (zeige DAPK3 Antikörper) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (zeige DAPK3 Antikörper) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (zeige MAP2K4 Antikörper)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (zeige DAPK3 Antikörper)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (zeige DAPK3 Antikörper) in turn controlled the levels of downstream JNK (zeige MAPK8 Antikörper) signaling and apoptosis.
DLK (zeige DAPK3 Antikörper) is required for RGC JNK (zeige MAPK8 Antikörper) activation and cell death in a rodent model of optic neuropathy
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (zeige DAPK3 Antikörper) is an essential upstream mediator of both of these divergent outcomes in the same cell type.
These data demonstrate that DLK (zeige DAPK3 Antikörper) enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program.
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
, dual leucine zipper bearing kinase
, dual leucine zipper kinase DLK
, leucine zipper protein kinase
, mixed lineage kinase
, protein kinase MUK
, Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
, Zipper (leucine) protein kinase
, dual leucine zipper kinase
, leucine-zipper protein kinase
, mitogen-activated protein kinase kinase kinase 12
, mitogen activated protein kinase kinase kinase 12
, zipper (leucine) protein kinase
, mitogen activated protein kinase kinase kinase 12 type A
, mitogen activated protein kinase kinase kinase 12 type B
, mitogen-activated protein kinase kinase kinase 12 L homeolog