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The TBK1 (zeige TBK1 ELISA Kits) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (zeige TBK1 ELISA Kits).
identified both Syk (zeige SYK ELISA Kits) and Src signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
results indicate that SRC likely plays a central role in regulating multiple unique signaling pathways activated by MTB (zeige NCAPG2 ELISA Kits) infection
c-Src tyrosine kinase (zeige CSK ELISA Kits) mediates high glucose-induced endothelin-1 (zeige EDN1 ELISA Kits) expression
PTPN2 (zeige PTPN2 ELISA Kits) is a positive regulator of lipopolysaccharide-induced inflammatory response by enhancing the activity of Src through targeting the inhibitory phosphor-tyrosine527 of Src.
demonstrated that both IL-10 (zeige IL10 ELISA Kits) and TGF-beta (zeige TGFB1 ELISA Kits) upregulated TIM-3 (zeige HAVCR2 ELISA Kits) surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src and Bruton's tyrosine kinase (zeige BTK ELISA Kits)
Results suggest that interleukin-6 (IL-6 (zeige IL6 ELISA Kits)) increases VEGF-C (zeige VEGFC ELISA Kits) induction and lymphangiogenesis may involve, at least in part, Src-FAK (zeige PTK2 ELISA Kits)-STAT3 (zeige STAT3 ELISA Kits) cascade in lymphatic endothelial cells (LECs).
Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line has been reported.
Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.
miR (zeige MLXIP ELISA Kits)-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K (zeige CTSK ELISA Kits) and TRAP.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (zeige TMOD4 ELISA Kits) (CP) alphabeta heterodimer, which regulates actin (zeige ACTB ELISA Kits) filament (F-actin (zeige ACTB ELISA Kits)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (zeige MAPK8 ELISA Kits) activation.
Dumbfounded/Neph1 (zeige NEPH1 ELISA Kits), a key diaphragm constituent, is a target of the Src kinase (zeige CSK ELISA Kits) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (zeige NEPH1 ELISA Kits) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (zeige ACTB ELISA Kits) formation and Jun kinase (zeige MAPK9 ELISA Kits) activation in plasmatocytes.
Data show that the solubilising factor UNC119 (zeige UNC119 ELISA Kits) sequesters myristoylated Src family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction.
Data indicate a role for AXL receptor tyrosine kinase (AXL (zeige AXL ELISA Kits)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (zeige EGFR ELISA Kits)) and suggest that AXL (zeige AXL ELISA Kits)-mediated SRC family kinases (SFKs) and neuregulin-1 (NRG1 (zeige NRG1 ELISA Kits)) expression promote this process.
High Src expression is associated with breast cancer.
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (zeige GRK5 ELISA Kits) and GRK6 (zeige GRK6 ELISA Kits), both of which regulate Src and IGF-IR signaling and have been implicated in cancer.
Src knockdown in Cal27 cells which led to a reduction in pSrc(Y418), as well as treatment with the pSrc(Y418) inhibitors dasatinib and PP2, conferred resistance to 4 anticancer drugs, indicating that the loss of pSrc(Y418) is responsible for the observed effect.
High SRC expression is associated with ovarian cancer.
RanBP9 (zeige RANBP9 ELISA Kits)/TSSC3 (zeige PHLDA2 ELISA Kits) complex cooperatively suppress metastasis via downregulation of Src-dependent Akt (zeige AKT1 ELISA Kits) pathway to expedite mitochondrial-associated anoikis.
In addition, EB1 (zeige MAPRE2 ELISA Kits) phosphorylation at Y247 by Src enhances the rate of microtubule catastrophe and significantly stimulates cell migration. These findings thus demonstrate that the Src-EB1 (zeige MAPRE2 ELISA Kits) axis plays a crucial role in regulating the crosstalk between microtubules and focal adhesions to promote cell migration.
Results indicate Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL) in driving tumor metastasis through c-Src activation, and suggests that hSH3BGRL mutation status could be relevant to cancer diagnosis and therapy.
RhoA (zeige RHOA ELISA Kits) and membrane fluidity mediates the spatially polarized Src/FAK (zeige PTK2 ELISA Kits) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (zeige TMPRSS5 ELISA Kits)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (zeige TGFB1 ELISA Kits)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (zeige PTK2 ELISA Kits)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 ELISA Kits) activity and SFK signaling.
Src kinase (zeige CSK ELISA Kits) mediates hypoxia-induced caspase-1 (zeige CASP1 ELISA Kits) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (zeige ATP1A1 ELISA Kits) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase