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OSM and OSMR are highly expressed in inflammatory bowel disease intestinal mucosa compared to control mucosa. Intestinal stromal cells express abundant OSMR.
OSM:OSMR interactions are able to induce EMT (zeige ITK Proteine), increased cancer stem cell-like properties and enhanced lung colonisation in SCC (zeige CYP11A1 Proteine) cells
the RET (zeige RET Proteine) p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis
this study offers new findings on the molecular genetics and disease relevance of mutations in OSMR in Familial primary localized cutaneous amyloidosis.
Oncostatin M (zeige OSM Proteine) and interleukin-31 (zeige IL31 Proteine): Cytokines, receptors, signal transduction and physiology.
primary localized cutaneous amyloidosis has a missense mutation in oncostatin M receptor beta
The interleukin IL-31 (zeige IL31 Proteine)/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
oncostatin M (zeige OSM Proteine) is a cytokine possessing vigorous antiviral and immunostimulatory properties which is released by APC (zeige APC Proteine) upon interaction with CD40L (zeige CD40LG Proteine) present on activated CD4 (zeige CD4 Proteine)+ T cells.
The disease severity of rheumatoid arthritis and systemic lupus erythematosus can be partially affected by the OSMR promoter polymorphisms.
We conclude that an OSMR/TGM2 (zeige TGM2 Proteine)/integrin-alpha5beta1/fibronectin (zeige FN1 Proteine) pathway is of biological significance in cervical squamous cell carcinoma
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis.
In astrocytes but not microglia, phosphorylation of STAT1 (zeige STAT1 Proteine) and STAT3 (zeige STAT3 Proteine) occurred in response to OSM (zeige OSM Proteine), whereas both microglia and astrocytes responded to hyper-IL-6 (IL-6 (zeige IL6 Proteine) linked to the soluble IL-6 (zeige IL6 Proteine) receptor).
OSM (zeige OSM Proteine) signaling via OSMR in synovial fibroblasts has the potential to contribute significantly to joint destruction in inflammatory arthritis.
defects in OSM (zeige OSM Proteine) signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders
Data indicate that OSM (zeige OSM Proteine) receptor beta subunit (zeige POLG Proteine)-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin (zeige INS Proteine) resistance.
These data indicate that the transient RANKL (zeige TNFSF11 Proteine) induction by intermittent PTH (zeige PTH Proteine) administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction.
Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling.
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons.
Mice deficient in OSM (zeige OSM Proteine) receptor showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride exposure. Recovery of liver mass from partial hepatectomy was also significantly delayed in OSMR(-/-) mice.
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IL-31 receptor subunit beta
, IL-31R subunit beta
, interleukin-31 receptor subunit beta
, oncostatin-M specific receptor beta subunit
, oncostatin-M-specific receptor subunit beta
, oncostatin receptor
, oncostatin-M specific receptor subunit beta
, oncostatin M specific receptor