anti-Leptin (LEP) Antikörper

Bezeichnung:
anti-Leptin Antikörper (LEP)
Auf www.antikoerper-online.de finden Sie aktuell 607 Leptin (LEP) Antikörper von 34 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Leptin Proteine (205) und Leptin Kits (199) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1048 Leptin Produkte verfügbar.
Synonyme:
LEPD, OB, obese, OBS

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Am meisten referenzierte anti-Leptin Antikörper

  1. Human Monoclonal Leptin Primary Antibody für EIA, WB - ABIN114695 : Maffei, Halaas, Ravussin, Pratley, Lee, Zhang, Fei, Kim, Lallone, Ranganathan: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. in Nature medicine 1995 (PubMed)
    Zeige alle 6 Referenzen für 114695

  2. Human Polyclonal Leptin Primary Antibody für EIA, IF - ABIN358628 : Tank, Jordan, Diedrich, Schroeder, Furlan, Sharma, Luft, Brabant: Bound leptin and sympathetic outflow in nonobese men. in The Journal of clinical endocrinology and metabolism 2003 (PubMed)
    Zeige alle 4 Referenzen für 358628

  3. Mouse (Murine) Polyclonal Leptin Primary Antibody für ELISA, WB - ABIN3043294 : Cheng, Dai, Dai: Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213. in Reproductive toxicology (Elmsford, N.Y.) 2010 (PubMed)
    Zeige alle 3 Referenzen für 3043294

  4. Human Polyclonal Leptin Primary Antibody für EIA, FACS - ABIN953161 : Friedlander, Li, Fornage, Williams, Lewis, Schreiner, Pletcher, Enquobahrie, Williams, Siscovick: Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. in Annals of human genetics 2010 (PubMed)
    Zeige alle 2 Referenzen für 953161

  5. Human Polyclonal Leptin Primary Antibody für EIA - ABIN318591 : Mantzoros: The role of leptin in human obesity and disease: a review of current evidence. in Annals of internal medicine 1999 (PubMed)

  6. Human Monoclonal Leptin Primary Antibody für ELISA, IF - ABIN1996123 : Sun, Park, Gupta, Holland, Auerbach, Zhang, Goncalves Marangoni, Nicoloro, Czech, Varga, Ploug, An, Scherer: Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction. in Nature communications 2014 (PubMed)

  7. Cow (Bovine) Polyclonal Leptin Primary Antibody für IHC, WB - ABIN2776943 : Müller, Kowalewski, Reichler, Kollár, Balogh: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. in Reproduction in domestic animals = Zuchthygiene 2017 (PubMed)

Weitere Antikörper gegen Leptin Interaktionspartner

Mouse (Murine) Leptin (LEP) Interaktionspartner

  1. leptin is involved in the proliferation and activation of microglia, which in turn enhances the development of neuropathic pain after avulsion of the cervical roots.

  2. Suggest that intact endothelial leptin signaling limits neointima formation and that obesity represents a state of endothelial leptin resistance.

  3. these studies demonstrate marked differences in the acute insulin (zeige INS Antikörper)-independent effects by which leptin reverses fasting hyperglycemia and ketoacidosis in a rodent model of DKA versus the chronic pleotropic effects by which leptin reverses hyperglycemia in a non-DKA rodent model of T1D.

  4. High fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most (but not all) brain regions, while other brain regions display hypersensitivity to leptin following weight loss

  5. CNS-specific Tak1 (zeige NR2C2 Antikörper) deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 (zeige NR2C2 Antikörper) is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.

  6. These data further implicate IL-6 (zeige IL6 Antikörper) in fatty liver disease modulation in the context of DIO, and indicate that continuous stimulation with IL-6 (zeige IL6 Antikörper) attenuates the IL-6 (zeige IL6 Antikörper)-receptor response, which is associated with high serum levels of leptin.

  7. these data unmasked a role for mitochondrial fission in leptin sensitivity and glucose sensing of POMC (zeige POMC Antikörper) neurons.

  8. Obesity and leptin deficiency substantially decreased morphine metabolism and clearance.

  9. These findings suggest that by impairing the testicular LEP-JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) pathway, early-stage obesity inhibits the biosynthesis of testosterone and sexual development and reduces male reproductive potential. Long-term moderate and high-volume exercise can effectively reduce body fat and improve obesity-induced abnormalities in testicular leptin signal transduction, whereas only moderate-volume exercise can reverse the negativ

  10. genetic and pharmacological ablation of adult NG2 (zeige Vcan Antikörper)-glia (also known as oligodendrocyte precursors), but not microglia, leads to primary leptin resistance and obesity in mice.

Human Leptin (LEP) Interaktionspartner

  1. Serum leptin levels were associated in patients with stable angina with the severity of coronary artery disease, suggesting its value in the development of coronary disease and as a future therapeutic target.

  2. In a sample selected for severe early onset childhood obesity, no leptin gene mutations leading to decreased proportion of bioactive leptin were identified.

  3. Maternal pre-pregnancy BMI is strongly associated with decreased cord blood LEP gene methylation and may mediate the well-known association between maternal pre-pregnancy BMI and neonatal adiposity

  4. hot flash association with insulin (zeige INS Antikörper) resistance is dependent on the combination of leptin and adiponectin (zeige ADIPOQ Antikörper) variables

  5. There was a strong relationship between growth hormone receptor (GHR (zeige GHR Antikörper))-d3/fl gene polymorphism status and leptin levels in acromegalic patients

  6. in human colon cancer, upregulation of leptin pathway members was shown with a large network of dysregulated transcripts being linked with worse overall survival.

  7. In European children, higher leptin concentration is associated with metabolic syndrome, even after adjusting for BMI or body fat mass, confirming an early role of leptin in MetS (zeige ETV3 Antikörper).

  8. Leptin, at concentrations with minimal or no activating effects on astrocytoma cells, enhanced growth and migration promoted by low doses of sPLA2-IIA (zeige PLA2G2A Antikörper). sPLA2-IIA (zeige PLA2G2A Antikörper) alone induced a transient phosphorylation pattern in the Src (zeige SRC Antikörper)/ERK (zeige EPHB2 Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper)/p70S6K (zeige RPS6KB1 Antikörper)/rS6 pathway through EGFR (zeige EGFR Antikörper) transactivation

  9. a novel mechanism by which compromised HDLECs maintain their homeostasis during inflammation mediated by leptin and IL-6 (zeige IL6 Antikörper)

  10. In this study of a predominantly minority population, no association between premorbid leptin levels and cancer incidence was demonstrated

Pig (Porcine) Leptin (LEP) Interaktionspartner

  1. The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.

  2. A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.

  3. The presence of leptin and ObR (zeige LEPR Antikörper)-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  4. Studied 3'UTR (zeige UTS2R Antikörper) leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.

  5. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  6. Data showing changes in expression patterns of LEP/LEPR (zeige LEPR Antikörper) in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR (zeige LEPR Antikörper) complex at early stages of pregnancy, possibly affecting the attachment process.

  7. Another funning discovery is ob-Rb (zeige LEPR Antikörper) mRNA in porcine endometrium was mainly negative-regulated by leptin

  8. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance

  9. Leptin and leptin receptor (zeige LEPR Antikörper) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

  10. The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.

Cow (Bovine) Leptin (LEP) Interaktionspartner

  1. Consistent with this, leptin enhanced GnRH (zeige GNRH1 Antikörper)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (zeige CA2 Antikörper)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.

  2. The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.

  3. A leptin SNP (LEPg.978) was significantly associated with a weight at one year.

  4. The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.

  5. Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.

  6. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (zeige NPY Antikörper) and insulin (zeige INS Antikörper) signaling pathways.

  7. Leptin R25C genotype impacted most traits associated with fatness.

  8. The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.

  9. Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (zeige NPY Antikörper)) release.

  10. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR (zeige LEPR Antikörper)/T945M affected significantly calving interval (P<0.01) only

Goat Leptin (LEP) Interaktionspartner

  1. polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production

Rabbit Leptin (LEP) Interaktionspartner

  1. study suggests that increased CSF (zeige CSF2 Antikörper) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (zeige IGF1 Antikörper) after traumatic brain injury, leads to accelerated fracture healing

  2. We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (zeige GHRL Antikörper).

  3. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (zeige PPARG Antikörper) and CD36 (zeige CD36 Antikörper) mRNA expression in hypercholesterolemic rabbits.

Horse (Equine) Leptin (LEP) Interaktionspartner

  1. Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.

  2. Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.

  3. Plasma levels of leptin (as well as glucose, insulin (zeige INS Antikörper), and growth hormone (zeige GH1 Antikörper)) are highly correlated with the duration of winter anovulatory phase.

  4. GHRL (zeige GHRL Antikörper), LEP, ADIP (zeige SSX2IP Antikörper), INS (zeige INS Antikörper) and CORT (zeige CORT Antikörper) concentrations were measured using radioimmunoassay

  5. positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares

Rhesus Monkey Leptin (LEP) Interaktionspartner

  1. The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (zeige ADIPOQ Antikörper), leptin, and resistin (zeige RETN Antikörper) in a set of four chair-restraint habituated intact adult male rhesus monkeys.

  2. results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction

Leptin (LEP) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Alternative names and synonyms associated with Leptin (LEP)

  • leptin (Lep) Antikörper
  • leptin (LEP) Antikörper
  • leptin (lep) Antikörper
  • LEPD Antikörper
  • OB Antikörper
  • obese Antikörper
  • OBS Antikörper

Bezeichner auf Proteinebene für anti-Leptin (LEP) Antikörper

obesity factor , leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , obese protein , obese, mouse, homolog of , obese

GENE ID SPEZIES
16846 Mus musculus
3952 Homo sapiens
25608 Rattus norvegicus
443534 Ovis aries
396832 Sus scrofa
280836 Bos taurus
100860794 Capra hircus
100008747 Oryctolagus cuniculus
373955 Gallus gallus
403616 Canis lupus familiaris
100034042 Equus caballus
493838 Felis catus
449638 Pan troglodytes
100716751 Cavia porcellus
698728 Macaca mulatta
548631 Takifugu rubripes
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