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Human IFNA Protein expressed in Escherichia coli (E. coli) - ABIN803851
Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: Gender specificity of altered human immune cytokine profiles in aging. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Study shows IFN-alpha rapidly induces a profound shift in whole brain network structure, impairing global functional connectivity and the efficiency of parallel information exchange.
The review focuses on the value of the type I and III interferon subtypes (alphas, beta and lambdas) as therapeutics for prevention and treatment of viral infections (influenza, herpes, human immunodeficiency virus and hepatitis viruses).
MiR (zeige MLXIP Proteine)-181a is an important mediator for interferons-induced SAMHD1 (zeige SAMHD1 Proteine) expression in astrocytes and microglia, but not for inhibition of HIV-1 infection induced by IFN-alpha.
the expression of certain TAM (zeige CCNA1 Proteine) components was reduced as a result of prolonged degradation of MYD88 (zeige MYD88 Proteine) by Porphyromonas gingivalis infection.
Type I interferons (IFNs) signature is seen in a significant proportion of anti-nuclear antibody-positive (ANA (zeige BTG3 Proteine)(+) individuals and appears to be associated with ANA (zeige BTG3 Proteine) titre and type of autoantibodies, rather than with the presence or development of clinical systemic autoimmune rheumatic diseases (SARDs) symptoms.
study found that endogenous IFNalpha autocrinally promotes the expression of Interferon-Stimulated Gene (ISG) mRNAs in IL-3 (zeige IL-3 Proteine)-, but not in IFNlambda3 plus IL-3 (zeige IL-3 Proteine)-, treated plasmacytoid dendritic cells (pDCs); production of IFNalpha by IFNlambda3 plus IL-3 (zeige IL-3 Proteine)-treated pDCs is mostly dependent on endogenously produced TNFalpha (zeige TNF Proteine)
results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (zeige IKBKE Proteine) and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)
These data suggest that plasmacytoid dendritic cells producing IFN-alpha and IL-33 (zeige IL33 Proteine) play a pivotal role in the chronic fibro-inflammatory responses underlying murine autoimmune pancreatitis and human IgG4-related autoimmune pancreatitis.
These findings also identify STAT3 (zeige STAT3 Proteine) as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha responsiveness.
Mothers of children affected by autoimmune congenital heart block had a significantly higher expression IFN-alpha.
The TBK1 (zeige TBK1 Proteine) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (zeige TBK1 Proteine).
this study introduces a novel pathway by which IFN-alpha serves as a proatherogenic mediator through repression of eNOS (zeige NOS3 Proteine)-dependent pathways
study reports that mitochondrial antiviral signaling protein (MAVS (zeige MAVS Proteine)), -mediated IFN-alpha/beta production and IFNAR (zeige IFNAR1 Proteine) signaling are required for alloimmune responses to the human K1 Ag in a murine model of inflammation-induced alloimmunization
CD169 (zeige SIGLEC1 Proteine)(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (zeige CD8A Proteine)(+) T-cell exhaustion and immunopathology.
These results suggest that pulmonary C-fibers affect IFNGR1 (zeige IFNGR1 Proteine) expression by inducing IFN-alpha to regulate IFN-gamma (zeige IFNG Proteine)-mediated airway inflammation and airway hyperresponsiveness.
results show that resistance to HSV-1 in the trigeminal ganglia during acute infection is conferred in part by STING and IFN-alpha/beta signaling in both bone marrow-derived and -resident cells, which coalesce to support a robust HSV-1-specific CD8 (zeige CD8A Proteine)(+) T cell response
the close association between the increased proportion of CD180 (zeige CD180 Proteine)-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported.
STAT2 (zeige STAT2 Proteine) recruits USP18 (zeige USP18 Proteine) to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Proteine) via its constitutive membrane-distal STAT2 (zeige STAT2 Proteine)-binding site.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon response by inducing STAT1 (zeige STAT1 Proteine) degradation.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 (zeige IRF3 Proteine) and subsequent degradation of IRF-3 (zeige IRF3 Proteine), leading to downregulation of IFN-alpha/beta production.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
Overall, data provide evidence for the possible role of PI3K in the activation of the transcription of IFN-alpha/beta by PRRSV; study concludes that PRRSV inhibits the induction of IFN-alpha in monocyte-derived dendritic cells by as yet undefined post-transcriptional mechanisms.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.
Expression of Mx protein (zeige MX2 Proteine) and interferon-alpha (IFN-alpha) was examined by immunohistochemistry in pigs experimentally infected with swine influenza virus.
Foot-and-Mouth Disease Virus inhibits IFN-alpha expression in infected cells by blocking cap-dependent translation.
produced in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus in lymph nodes cells expressing the myeloid markers CD14 (zeige CD14 Proteine), CD11b (zeige ITGAM Proteine), and CD172a (zeige SIRPA Proteine)
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (zeige STAT1 Proteine) and, to a lesser extent, STAT2 (zeige STAT2 Proteine).
The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted.
, interferon alpha
, interferon alpha 7
, IFN-alpha 1b
, interferon alpha 1b
, interferon alpha-1/13
, interferon alpha-D
, leIF D
, interferon alpha family gene 1
, interferon alpha-1
, interferon alpha 1
, IFN alpha
, interferon type A1/A2
, interferon type A3
, interferon alpha A
, Interferon alpha-1